Daniela Alterio, Simona Marani, Sabrina Vigorito, Valeria Zurlo, Stefano Filippo Zorzi, Annamaria Ferrari, Stefania Volpe, Francesco Bandi, Maria Giulia Vincini, Sara Gandini, Aurora Gaeta, Cristiana Iuliana Fodor, Alessia Casbarra, Mattia Zaffaroni, Anna Starzynska, Liliana Belgioia, Mohssen Ansarin, Cynthia Aristei, Barbara Alicja Jereczek-Fossa
{"title":"声门上区喉肿瘤保守手术后的术后调强放疗与三维适形放疗：对20名患者的剂量学分析。","authors":"Daniela Alterio, Simona Marani, Sabrina Vigorito, Valeria Zurlo, Stefano Filippo Zorzi, Annamaria Ferrari, Stefania Volpe, Francesco Bandi, Maria Giulia Vincini, Sara Gandini, Aurora Gaeta, Cristiana Iuliana Fodor, Alessia Casbarra, Mattia Zaffaroni, Anna Starzynska, Liliana Belgioia, Mohssen Ansarin, Cynthia Aristei, Barbara Alicja Jereczek-Fossa","doi":"10.14639/0392-100X-N2442","DOIUrl":null,"url":null,"abstract":"<p><strong>Objective: </strong>To perform a dosimetric comparison between intensity modulated radiotherapy (IMRT) and 3D conformal radiotherapy in patients with locally advanced (stage III and IV) tumours of the supraglottic region treated with conservative surgery and post-operative radiotherapy.</p><p><strong>Methods: </strong>An in-silico plan using a 3D conformal shrinking field technique was retrospectively produced for 20 patients and compared with actually delivered IMRT plans. Eighteen structures (arytenoids, constrictor muscles, base of tongue, floor of mouth, pharyngeal axis, oral cavity, submandibular glands and muscles of the swallowing functional units [SFU]) were considered.</p><p><strong>Results: </strong>IMRT allowed a reduction of maximum and mean doses to 9 and 14 structures, respectively (p < .05).</p><p><strong>Conclusions: </strong>IMRT achieved a reduction of unnecessary dose to the remnant larynx and the majority of surrounding SFUs. Further prospective analyses and correlations with functional clinical outcomes are required to confirm these dosimetric findings.</p>","PeriodicalId":6890,"journal":{"name":"Acta Otorhinolaryngologica Italica","volume":" ","pages":"150-160"},"PeriodicalIF":2.1000,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11166212/pdf/","citationCount":"0","resultStr":"{\"title\":\"Post-operative intensity-modulated vs 3D conformal radiotherapy after conservative surgery for laryngeal tumours of the supraglottic region: a dosimetric analysis on 20 patients.\",\"authors\":\"Daniela Alterio, Simona Marani, Sabrina Vigorito, Valeria Zurlo, Stefano Filippo Zorzi, Annamaria Ferrari, Stefania Volpe, Francesco Bandi, Maria Giulia Vincini, Sara Gandini, Aurora Gaeta, Cristiana Iuliana Fodor, Alessia Casbarra, Mattia Zaffaroni, Anna Starzynska, Liliana Belgioia, Mohssen Ansarin, Cynthia Aristei, Barbara Alicja Jereczek-Fossa\",\"doi\":\"10.14639/0392-100X-N2442\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Objective: </strong>To perform a dosimetric comparison between intensity modulated radiotherapy (IMRT) and 3D conformal radiotherapy in patients with locally advanced (stage III and IV) tumours of the supraglottic region treated with conservative surgery and post-operative radiotherapy.</p><p><strong>Methods: </strong>An in-silico plan using a 3D conformal shrinking field technique was retrospectively produced for 20 patients and compared with actually delivered IMRT plans. Eighteen structures (arytenoids, constrictor muscles, base of tongue, floor of mouth, pharyngeal axis, oral cavity, submandibular glands and muscles of the swallowing functional units [SFU]) were considered.</p><p><strong>Results: </strong>IMRT allowed a reduction of maximum and mean doses to 9 and 14 structures, respectively (p < .05).</p><p><strong>Conclusions: </strong>IMRT achieved a reduction of unnecessary dose to the remnant larynx and the majority of surrounding SFUs. Further prospective analyses and correlations with functional clinical outcomes are required to confirm these dosimetric findings.</p>\",\"PeriodicalId\":6890,\"journal\":{\"name\":\"Acta Otorhinolaryngologica Italica\",\"volume\":\" \",\"pages\":\"150-160\"},\"PeriodicalIF\":2.1000,\"publicationDate\":\"2024-06-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11166212/pdf/\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Acta Otorhinolaryngologica Italica\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.14639/0392-100X-N2442\",\"RegionNum\":4,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"2024/4/30 0:00:00\",\"PubModel\":\"Epub\",\"JCR\":\"Q2\",\"JCRName\":\"OTORHINOLARYNGOLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Acta Otorhinolaryngologica Italica","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.14639/0392-100X-N2442","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2024/4/30 0:00:00","PubModel":"Epub","JCR":"Q2","JCRName":"OTORHINOLARYNGOLOGY","Score":null,"Total":0}
Post-operative intensity-modulated vs 3D conformal radiotherapy after conservative surgery for laryngeal tumours of the supraglottic region: a dosimetric analysis on 20 patients.
Objective: To perform a dosimetric comparison between intensity modulated radiotherapy (IMRT) and 3D conformal radiotherapy in patients with locally advanced (stage III and IV) tumours of the supraglottic region treated with conservative surgery and post-operative radiotherapy.
Methods: An in-silico plan using a 3D conformal shrinking field technique was retrospectively produced for 20 patients and compared with actually delivered IMRT plans. Eighteen structures (arytenoids, constrictor muscles, base of tongue, floor of mouth, pharyngeal axis, oral cavity, submandibular glands and muscles of the swallowing functional units [SFU]) were considered.
Results: IMRT allowed a reduction of maximum and mean doses to 9 and 14 structures, respectively (p < .05).
Conclusions: IMRT achieved a reduction of unnecessary dose to the remnant larynx and the majority of surrounding SFUs. Further prospective analyses and correlations with functional clinical outcomes are required to confirm these dosimetric findings.
期刊介绍：
Acta Otorhinolaryngologica Italica first appeared as “Annali di Laringologia Otologia e Faringologia” and was founded in 1901 by Giulio Masini.
It is the official publication of the Italian Hospital Otology Association (A.O.O.I.) and, since 1976, also of the Società Italiana di Otorinolaringoiatria e Chirurgia Cervico-Facciale (S.I.O.Ch.C.-F.).
The journal publishes original articles (clinical trials, cohort studies, case-control studies, cross-sectional surveys, and diagnostic test assessments) of interest in the field of otorhinolaryngology as well as clinical techniques and technology (a short report of unique or original methods for surgical techniques, medical management or new devices or technology), editorials (including editorial guests – special contribution) and letters to the Editor-in-Chief.
Articles concerning science investigations and well prepared systematic reviews (including meta-analyses) on themes related to basic science, clinical otorhinolaryngology and head and neck surgery have high priority.
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