基质金属蛋白酶 2 信号通路的基因多态性和 SNP-SNP 相互作用与血管衰老风险之间的关系

Zhen Yu Liao, Shuo Yang, Song Hu, Jia Liu, Yong Jun Mao, Shu Qin Sun
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引用次数: 0

摘要

研究目的本研究旨在探讨基质金属蛋白酶2(MMP-2)信号通路中单核苷酸多态性(SNP)与血管衰老(VS)风险的相关性:这项横断面研究在 2022 年 5 月至 11 月间收集了 151 名 VS 患者(病例组)和 233 名志愿者(对照组)的外周静脉血。研究人员通过颈动脉-股动脉脉搏波速度(cfPWV)评估了编码 MMP-2 信号通路成分的五个基因中的 14 个 SNPs,并使用多变量逻辑回归进行了分析。使用多因素降维(MDR)和广义多因素降维回归(GMDR)模型评估了多基因对VS风险的影响:结果:在多变量逻辑回归模型中,筛选出四个SNP与VS有显著关联:趋化因子(C-C motif)配体2(CCL2)rs4586、MMP2 rs14070、MMP2 rs7201和MMP2 rs1053605。与 C/C 基因型的人相比,MMP2 rs14070 的 T/C 基因型携带者罹患 VS 的风险增加了 2.17 倍,而 T/T 基因型携带者罹患 VS 的风险增加了 19.375 倍。CCL2 rs4586和MMP-2 rs14070的交互作用最为显著:结论:CCL2 rs4586、MMP-2 rs14070、MMP-2 rs7201 和 MMP-2 rs1053605 多态性与 VS 风险显著相关。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Association between Gene Polymorphisms and SNP-SNP Interactions of the Matrix Metalloproteinase 2 Signaling Pathway and the Risk of Vascular Senescence.

Objective: This study aimed to explore the association of single nucleotide polymorphisms (SNP) in the matrix metalloproteinase 2 (MMP-2) signaling pathway and the risk of vascular senescence (VS).

Methods: In this cross-sectional study, between May and November 2022, peripheral venous blood of 151 VS patients (case group) and 233 volunteers (control group) were collected. Fourteen SNPs were identified in five genes encoding the components of the MMP-2 signaling pathway, assessed through carotid-femoral pulse wave velocity (cfPWV), and analyzed using multivariate logistic regression. The multigene influence on the risk of VS was assessed using multifactor dimensionality reduction (MDR) and generalized multifactor dimensionality regression (GMDR) modeling.

Results: Within the multivariate logistic regression models, four SNPs were screened to have significant associations with VS: chemokine (C-C motif) ligand 2 (CCL2) rs4586, MMP2 rs14070, MMP2 rs7201, and MMP2 rs1053605. Carriers of the T/C genotype of MMP2 rs14070 had a 2.17-fold increased risk of developing VS compared with those of the C/C genotype, and those of the T/T genotype had a 19.375-fold increased risk. CCL2 rs4586 and MMP-2 rs14070 exhibited the most significant interactions.

Conclusion: CCL2 rs4586, MMP-2 rs14070, MMP-2 rs7201, and MMP-2 rs1053605 polymorphisms were significantly associated with the risk of VS.

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