Chao Liang PhD, Zhenpeng Song MM, XiaoZhi Yao PhD, Qian Xiao MM, Hehui Fu MM, Lixu Tang PhD
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引用次数: 0
摘要
内皮功能障碍是高血压发生的关键因素,而运动对改善高血压患者内皮功能的效果仍存在争议。作者采用荟萃分析法评估了运动对高血压患者内皮功能的干预效果,并研究了可能具有更大干预效果的运动方案。共纳入 37 项研究和 2801 名参与者。结果如下:内源性一氧化氮(NO)[SMD = .89, 95% CI (.48, 1.30), p
Exercise interventions for the effect of endothelial function in hypertensive patients: A systematic review and meta-analysis
Endothelial dysfunction is crucial factor to the hypertension occurrence, and controversy remains regarding the effect of exercise on improving endothelial function in hypertensive patients. The authors used meta-analysis to evaluate the intervention effect of exercise on endothelial function in hypertensive patients and to investigate exercise protocols that may have a greater intervention effect. A total of 37 studies and a total of 2801 participants were included. The results were as follows: endogenous nitric oxide (NO)[SMD = .89, 95% CI (.48, 1.30), p < .0001], endothelin-1 (ET-1): [SMD = −.94, 95% CI (−1.15, −.73), p <. 0001], flow-mediated dilation (FMD) [SMD = −.57, 95% CI (.36, .79), p < .000001]. In subgroup analysis, high-intensity aerobic exercise, with a single exercise duration of 35–50 min, 3–4 times/week for a total of 10–12 weeks, had the largest amount of intervention effect on NO, and moderate-intensity resistance exercise, with a single exercise duration of ≥60 min, 6 times/week for a total of 15–18 weeks, had the largest amount of intervention effect on ET-1. In conclusion, exercise can improve NO levels, FDM levels, and reduce ET-1 secretion of hypertension patients, thereby improve their endothelial function. The ideal intervention effect of improving NO level was more likely to be obtained by taking the exercise prescription of high-intensity aerobic exercise with a single exercise duration of 35–50 min, 3–4 times/week for 10–12 weeks; the ideal intervention effect of improving ET-1 was more likely to be obtained by taking the exercise prescription of oderate -intensity resistance exercise with a single exercise duration of ≥60 min, 6 times/week for 15–18 weeks.
期刊介绍:
The Journal of Clinical Hypertension is a peer-reviewed, monthly publication that serves internists, cardiologists, nephrologists, endocrinologists, hypertension specialists, primary care practitioners, pharmacists and all professionals interested in hypertension by providing objective, up-to-date information and practical recommendations on the full range of clinical aspects of hypertension. Commentaries and columns by experts in the field provide further insights into our original research articles as well as on major articles published elsewhere. Major guidelines for the management of hypertension are also an important feature of the Journal. Through its partnership with the World Hypertension League, JCH will include a new focus on hypertension and public health, including major policy issues, that features research and reviews related to disease characteristics and management at the population level.