利用β细胞再生生物学治疗糖尿病。

IF 11.4 1区 医学 Q1 ENDOCRINOLOGY & METABOLISM
Trends in Endocrinology and Metabolism Pub Date : 2024-11-01 Epub Date: 2024-04-21 DOI:10.1016/j.tem.2024.03.006
Stephanie Bourgeois, Sophie Coenen, Laure Degroote, Lien Willems, Annelore Van Mulders, Julie Pierreux, Yves Heremans, Nico De Leu, Willem Staels
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引用次数: 0

摘要

糖尿病的流行规模令人震惊,其并发症仍具有毁灭性,而目前的治疗方法仍给患者和整个医疗系统带来沉重负担。胰岛素分泌的胰岛β细胞遭到破坏或功能失调是糖尿病的根源,要真正治愈糖尿病,就必须恢复和保护胰岛β细胞。一种有吸引力的策略是直接在胰腺内再生β细胞;然而,虽然过去提出了几种再生β细胞的方法,但临床转化被证明具有挑战性。本综述仔细研究了β细胞再生的最新发现,并讨论了其临床应用的可能性。在此,我们旨在为创新的靶向疗法划定一条道路,以帮助从 "护理 "糖尿病转变为 "治疗 "糖尿病。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Harnessing beta cell regeneration biology for diabetes therapy.

The pandemic scale of diabetes mellitus is alarming, its complications remain devastating, and current treatments still pose a major burden on those affected and on the healthcare system as a whole. As the disease emanates from the destruction or dysfunction of insulin-producing pancreatic β-cells, a real cure requires their restoration and protection. An attractive strategy is to regenerate β-cells directly within the pancreas; however, while several approaches for β-cell regeneration have been proposed in the past, clinical translation has proven challenging. This review scrutinizes recent findings in β-cell regeneration and discusses their potential clinical implementation. Hereby, we aim to delineate a path for innovative, targeted therapies to help shift from 'caring for' to 'curing' diabetes.

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来源期刊
Trends in Endocrinology and Metabolism
Trends in Endocrinology and Metabolism 医学-内分泌学与代谢
CiteScore
20.10
自引率
0.00%
发文量
98
审稿时长
82 days
期刊介绍: Trends in Endocrinology and Metabolism (TEM) stands as a premier Reviews journal in the realms of metabolism and endocrinology. Our commitment is reflected in the publication of refined, concise, and highly impactful articles that delve into cutting-edge topics, encompassing basic, translational, and clinical aspects. From state-of-the-art treatments for endocrine diseases to groundbreaking developments in molecular biology, TEM provides comprehensive coverage. Explore recent advancements in diabetes, endocrine diseases, obesity, neuroendocrinology, immunometabolism, molecular and cellular biology, and a myriad of other areas through our journal. TEM serves as an invaluable resource for researchers, clinicians, lecturers, teachers, and students. Each monthly issue is anchored by Reviews and Opinion articles, with Reviews meticulously chronicling recent and significant developments, often contributed by leading researchers in specific fields. Opinion articles foster debate and hypotheses. Our shorter pieces include Science & Society, shedding light on issues at the intersection of science, society, and policy; Spotlights, which focus on exciting recent developments in the literature, and single-point hypotheses as Forum articles. We wholeheartedly welcome and encourage responses to previously published TEM content in the form of Letters.
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