{"title":"正念冥想训练通过重塑默认模式网络和执行控制相关脑区之间的功能连接，减少对游戏的渴望。","authors":"","doi":"10.1016/j.bpsc.2024.04.011","DOIUrl":null,"url":null,"abstract":"<div><h3>Background</h3><p>Internet gaming disorder<span> (IGD) can lead to psychological problems and cause behavioral problems in individuals. Traditional interventions have been ineffective in treating IGD. Meanwhile, mindfulness meditation (MM) is an emerging method that has proven to be effective for treating psychiatric disorders. In this study, MM was used to intervene in IGD and to explore its neural mechanism.</span></p></div><div><h3>Methods</h3><p>Eighty participants were recruited through advertisements. Eventually, 61 completed the 1-month training (MM group, <em>n</em> = 31; progressive muscle relaxation [PMR] group, <em>n</em><span> = 30), including a pretest, 8 training sessions, and a posttest. Regional homogeneity and degree centrality were calculated, and the tests (pre- and post-) and group (MM and PMR) analysis of variance was performed. The overlapping results were obtained as region of interest for functional connectivity<span> (FC) analyses. Behavioral data and neurotransmitter availability maps were correlated with FC.</span></span></p></div><div><h3>Results</h3><p><span>Compared with PMR, MM decreased the severity of addiction and game craving in IGD. Brain imaging results showed that the FC between and within the executive control and default mode networks/reward-related regions were enhanced. Significant negative correlations were observed between FC and dopamine receptor D</span><sub>2</sub><span><span>, dopamine transporter, and </span>vesicular acetylcholine transporter<span>. Significant positive correlations were observed between FCs and serotonin and aminobutyric acid receptors.</span></span></p></div><div><h3>Conclusions</h3><p>This study confirmed the effectiveness of MM in treating IGD. MM altered the default mode and enhanced top-down control over game cravings. These findings were revealed by the correlations between brain regions and behavioral and biochemical effects. The results show the neural mechanism of MM in reducing IGD and lay the foundation for future research.</p></div>","PeriodicalId":54231,"journal":{"name":"Biological Psychiatry-Cognitive Neuroscience and Neuroimaging","volume":"9 8","pages":"Pages 827-836"},"PeriodicalIF":5.7000,"publicationDate":"2024-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Mindfulness Meditation Training Reduces Gaming Cravings by Reshaping the Functional Connectivity Between the Default Mode Network and Executive Control–Related Brain Regions\",\"authors\":\"\",\"doi\":\"10.1016/j.bpsc.2024.04.011\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><h3>Background</h3><p>Internet gaming disorder<span> (IGD) can lead to psychological problems and cause behavioral problems in individuals. Traditional interventions have been ineffective in treating IGD. Meanwhile, mindfulness meditation (MM) is an emerging method that has proven to be effective for treating psychiatric disorders. In this study, MM was used to intervene in IGD and to explore its neural mechanism.</span></p></div><div><h3>Methods</h3><p>Eighty participants were recruited through advertisements. Eventually, 61 completed the 1-month training (MM group, <em>n</em> = 31; progressive muscle relaxation [PMR] group, <em>n</em><span> = 30), including a pretest, 8 training sessions, and a posttest. Regional homogeneity and degree centrality were calculated, and the tests (pre- and post-) and group (MM and PMR) analysis of variance was performed. The overlapping results were obtained as region of interest for functional connectivity<span> (FC) analyses. Behavioral data and neurotransmitter availability maps were correlated with FC.</span></span></p></div><div><h3>Results</h3><p><span>Compared with PMR, MM decreased the severity of addiction and game craving in IGD. Brain imaging results showed that the FC between and within the executive control and default mode networks/reward-related regions were enhanced. Significant negative correlations were observed between FC and dopamine receptor D</span><sub>2</sub><span><span>, dopamine transporter, and </span>vesicular acetylcholine transporter<span>. Significant positive correlations were observed between FCs and serotonin and aminobutyric acid receptors.</span></span></p></div><div><h3>Conclusions</h3><p>This study confirmed the effectiveness of MM in treating IGD. MM altered the default mode and enhanced top-down control over game cravings. These findings were revealed by the correlations between brain regions and behavioral and biochemical effects. The results show the neural mechanism of MM in reducing IGD and lay the foundation for future research.</p></div>\",\"PeriodicalId\":54231,\"journal\":{\"name\":\"Biological Psychiatry-Cognitive Neuroscience and Neuroimaging\",\"volume\":\"9 8\",\"pages\":\"Pages 827-836\"},\"PeriodicalIF\":5.7000,\"publicationDate\":\"2024-08-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Biological Psychiatry-Cognitive Neuroscience and Neuroimaging\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S2451902224001137\",\"RegionNum\":2,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q1\",\"JCRName\":\"NEUROSCIENCES\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Biological Psychiatry-Cognitive Neuroscience and Neuroimaging","FirstCategoryId":"3","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S2451902224001137","RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"NEUROSCIENCES","Score":null,"Total":0}
引用次数: 0
摘要
背景：网络游戏障碍（IGD）会导致心理问题并引发个人行为问题。传统的干预措施在治疗网络游戏障碍方面效果不佳。与此同时，正念冥想（MM）是一种新兴的方法，已被证明对治疗精神障碍有效。本研究采用正念冥想干预IGD，并探索其神经机制：方法：通过广告招募了 80 名参与者。最终，61人完成了为期一个月的训练（MM/渐进式肌肉放松：31/30），包括一次前测、八次训练和一次后测。计算了区域同质性和度中心性，并进行了测试（测试前和测试后）和分组（MM 和 PMR）方差分析。重叠结果作为功能连接（FC）分析的 ROI。行为数据和神经递质与功能连接相关：结果：与PMR相比，MM能降低IGD的成瘾严重程度和游戏渴求。脑成像结果显示，执行控制和默认模式网络（DMN）/奖励相关区域之间和内部的FC增强了。FC与多巴胺受体D2、多巴胺转运体（DAT）和乙酰胆碱受体VAChT之间呈显著负相关。FC与血清素和氨基丁酸受体之间呈显著正相关：本研究证实了 MM 治疗 IGD 的有效性。MM改变了默认模式，增强了自上而下对游戏渴望的控制。脑区与行为和生化效应之间的相关性揭示了这些发现。这些结果显示了 MM 在减少 IGD 方面的神经机制，为今后的研究奠定了基础。
Mindfulness Meditation Training Reduces Gaming Cravings by Reshaping the Functional Connectivity Between the Default Mode Network and Executive Control–Related Brain Regions
Background
Internet gaming disorder (IGD) can lead to psychological problems and cause behavioral problems in individuals. Traditional interventions have been ineffective in treating IGD. Meanwhile, mindfulness meditation (MM) is an emerging method that has proven to be effective for treating psychiatric disorders. In this study, MM was used to intervene in IGD and to explore its neural mechanism.
Methods
Eighty participants were recruited through advertisements. Eventually, 61 completed the 1-month training (MM group, n = 31; progressive muscle relaxation [PMR] group, n = 30), including a pretest, 8 training sessions, and a posttest. Regional homogeneity and degree centrality were calculated, and the tests (pre- and post-) and group (MM and PMR) analysis of variance was performed. The overlapping results were obtained as region of interest for functional connectivity (FC) analyses. Behavioral data and neurotransmitter availability maps were correlated with FC.
Results
Compared with PMR, MM decreased the severity of addiction and game craving in IGD. Brain imaging results showed that the FC between and within the executive control and default mode networks/reward-related regions were enhanced. Significant negative correlations were observed between FC and dopamine receptor D2, dopamine transporter, and vesicular acetylcholine transporter. Significant positive correlations were observed between FCs and serotonin and aminobutyric acid receptors.
Conclusions
This study confirmed the effectiveness of MM in treating IGD. MM altered the default mode and enhanced top-down control over game cravings. These findings were revealed by the correlations between brain regions and behavioral and biochemical effects. The results show the neural mechanism of MM in reducing IGD and lay the foundation for future research.
期刊介绍：
Biological Psychiatry: Cognitive Neuroscience and Neuroimaging is an official journal of the Society for Biological Psychiatry, whose purpose is to promote excellence in scientific research and education in fields that investigate the nature, causes, mechanisms, and treatments of disorders of thought, emotion, or behavior. In accord with this mission, this peer-reviewed, rapid-publication, international journal focuses on studies using the tools and constructs of cognitive neuroscience, including the full range of non-invasive neuroimaging and human extra- and intracranial physiological recording methodologies. It publishes both basic and clinical studies, including those that incorporate genetic data, pharmacological challenges, and computational modeling approaches. The journal publishes novel results of original research which represent an important new lead or significant impact on the field. Reviews and commentaries that focus on topics of current research and interest are also encouraged.
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