草药疗法:草药分子的可控、定向递送和成像。

Q1 Pharmacology, Toxicology and Pharmaceutics
Nanotheranostics Pub Date : 2024-03-25 eCollection Date: 2024-01-01 DOI:10.7150/ntno.94987
Aseem Setia, Bhaskar Vallamkonda, Randheer Reddy Challa, Abhishesh Kumar Mehata, Paresh Badgujar, Madaswamy S Muthu
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引用次数: 0

摘要

现代医学依赖于少数关键的生物制剂,这些生物制剂可以在自然界中找到,但在使用前需要进一步表征和提纯。由于草药是通过过时且无效的给药方法给药的,因此其药效大打折扣。新型给药方式有可能提高草药的疗效,同时减少其副作用。这就是在草药治疗中采用不同给药方式的主要理念。与传统配方相比,草药化合物的新型配方具有多种优势。这些好处包括增强对组织的渗透能力、持续提供有效剂量以及耐物理和化学降解。包括草药成分在内的可控和靶向给药允许采用更传统的剂量,同时提高药效。增强全身给药中草药的生物分布和靶点蓄积是纳米药物制剂的目标。通过在单一纳米级平台上结合诊断和治疗功能,纳米otheranostics 领域在草药化合物的开发方面取得了重大进展。至关重要的是,要创建一个源于植物且本质上 "一体化 "的单分子治疗纳米平台。除了研究纳米粒子合成的机理方法外,本综述还强调了纳米级植物化学递送系统的治疗效果。此外,我们还评估了该领域未来的发展空间,讨论了最近开发的几种用于草药成像的纳米粒子,并提供了支持其使用的实验证据。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Herbal Theranostics: Controlled, Targeted Delivery and Imaging of Herbal Molecules.

Modern medicine relies on a small number of key biologics, which can be found in nature but require further characterization and purification before they can be used. Since the herbal remedy is given through a dated and ineffective method of drug administration, its effectiveness is diminished. The novel form of medicine delivery has the potential to increase the effectiveness of herbal substances while decreasing their side effects. This is the main idea behind utilising different ways of drug delivery in herbal treatments. Several benefits arise from novel formulations of herbal compounds as compared to their conventional counterparts. These include enhanced penetrating ability into tissues, constant delivery of effective doses, and resistance to physical and chemical degradation. Controlled and targeted delivery that include herbal components allow for more traditional dosing while simultaneously increasing their efficacy. Enhancing the biodistribution and target site accumulation of systemically administered herbal medicines is the goal of nanomedicine formulations. The field of nanotheranostics has made significant advancements in the development of herbal compounds by combining diagnostic and therapeutic functions on a single nanoscale platform. It is critically important to create a theranostic nanoplatform that is derived from plants and is intrinsically "all-in-one" for single molecules. In addition to examining the mechanistic approach to nanoparticle synthesis, this review highlights the therapeutic effects of nanoscale phytochemical delivery systems. Furthermore, we have evaluated the scope for future advancements in this field, discussed several nanoparticles that have been developed recently for herbal imaging, and provided experimental evidence that supports their usage.

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来源期刊
Nanotheranostics
Nanotheranostics Pharmacology, Toxicology and Pharmaceutics-Pharmacology, Toxicology and Pharmaceutics (miscellaneous)
CiteScore
10.40
自引率
0.00%
发文量
37
审稿时长
12 weeks
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