利用计算流体力学评估气管狭窄对气道阻力和呼吸功的影响

Q3 Medicine
Tanaffos Pub Date : 2023-02-01
Mojdeh Monjezi, Milad Rismanian, Arda Kiani, Atefeh Abedini, Hamidreza Jamaati
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引用次数: 0

摘要

背景:支气管镜检查是诊断气道狭窄最准确的方法之一,也是一种侵入性检查。然而,在进行支气管镜检查之前,快速、无创地估计管腔阻塞面积百分比(%AO)有助于做出决策。我们假设气管阻塞面积百分比与气管对液体流动的阻力之间存在关系:通过测量气道阻力,可在手术前估算出%AO。本研究使用计算流体动力学(CFD)模拟了流体流经网状狭窄气管模型的情况。在气管中插入一个圆柱段,代表与 20%、40%、60% 和 80% AO 相对应的横截面积。研究了这些模型中的流体流动和压力分布。我们的 CFD 模拟结果表明,气管阻力随 AO% 的增加而呈指数增加:结果:模拟结果显示,当气道阻力为 80% 时,肺气道阻力和呼吸阻力功分别增加了 130% 和 55%。此外,根据人体胸透或强迫振荡技术测量的气道阻力,还得到了一个曲线拟合关系来估算 AO%:结论:这种预估方法对气管狭窄患者的诊断评估和治疗计划非常有用。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Evaluation of the Tracheal Stenosis Effects on Airway Resistance and Work of Breathing Using Computational Fluid Dynamics.

Background: Bronchoscopy is one of the most accurate procedures to diagnose airway stenosis which is an invasive procedure. However, a quick and noninvasive estimation of the percent area of obstruction (%AO) of the lumen is helpful in decision-making before performing a bronchoscopy procedure. We hypothesized that there is a relationship between %AO and tracheal resistance against fluid flow.

Materials and methods: By measuring airway resistance, %AO could be estimated before the procedure. Using computational fluid dynamics (CFD), this study simulates the fluid flow through trachea models with web-liked stenosis using CFD. A cylindrical segment was inserted into the trachea to represent cross-sectional areas corresponding to 20%, 40%, 60%, and 80% AO. The fluid flow and pressure distribution in these models were studied. Our CFD simulations revealed that the tracheal resistance is exponentially increased by %AO.

Results: The results showed a 130% and 55% increase in lung airway resistance and resistive work of breathing for an 80% AO, respectively. Moreover, a curve-fitted relationship was obtained to estimate %AO based on the measured airway resistance by body plethysmography or forced oscillation technique.

Conclusion: This pre-estimation is very useful in diagnostic evaluation and treatment planning in patients with tracheal stenosis.

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来源期刊
Tanaffos
Tanaffos Medicine-Critical Care and Intensive Care Medicine
CiteScore
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