解决肥胖问题。

IF 11.4 1区医学 Q1 ENDOCRINOLOGY & METABOLISM

Trends in Endocrinology and Metabolism Pub Date : 2024-06-01 Epub Date: 2024-04-09 DOI:10.1016/j.tem.2024.04.001

Gabriel O de Souza, Willian O Dos Santos, Jose Donato

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引用次数: 0

摘要

肥胖与调节新陈代谢的下丘脑神经元功能障碍有关，其中包括表达激动相关蛋白（AgRP）的神经元。在最近的一篇文章中，Zhang 等人证实，饮食或基因诱导的肥胖会促进 AgRP 神经元中铁的蓄积。防止AgRP神经元的铁超载可减轻饮食诱导的肥胖和雄性小鼠的相关并发症。

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Ironing out obesity.

Obesity is associated with dysfunctions in hypothalamic neurons that regulate metabolism, including agouti-related protein (AgRP)-expressing neurons. In a recent article, Zhang et al. demonstrated that either diet- or genetically induced obesity promoted iron accumulation specifically in AgRP neurons. Preventing iron overload in AgRP neurons mitigated diet-induced obesity and related comorbidities in male mice.

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来源期刊

Trends in Endocrinology and Metabolism 医学-内分泌学与代谢

CiteScore

20.10

自引率

0.00%

发文量

审稿时长

82 days

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