蝴蝶杂交种染色体融合的减数分裂驱动力

IF 4.6 Q2 MATERIALS SCIENCE, BIOMATERIALS
Jesper Boman, Christer Wiklund, Roger Vila, Niclas Backström
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引用次数: 0

摘要

物种往往在染色体的数量和结构上存在差异,但染色体重排的杂合个体可能会降低适应性。因此,染色体重排(如裂片和融合)可以作为初生种系之间物种分化的一种机制,但其进化却带来了一个悖论。如果杂合子的适合度降低,那么重排如何在种群之间固定下来?一种解决方案是,这一过程主要发生在小规模和孤立的种群中,在这些种群中,遗传漂变可能会超越自然选择。然而,如果新的重排受到传播偏倚(如减数分裂驱动)的青睐,那么固定化也更有可能发生。在这里,我们研究了两个具有广泛核型差异的木白(Leptidea sinapis)蝴蝶种群杂交后代的染色体传递畸变。利用来自两个不同杂交实验的数据,我们发现,对于衍生的融合体来说,存在着有利于祖先染色体状态的传递偏差,这一结果表明,尽管减数分裂驱动力起着抵消作用,但染色体融合实际上可以在种群中固定下来。这意味着减数分裂驱动力不仅能促进染色体数目的失控进化和物种分化,还能成为一种保守的力量,对抗核型变化和生殖隔离的进化。基于我们的研究结果,我们提出了一个染色体融合突变可能受到减数分裂驱动反对的机理模型,并讨论了鳞翅目昆虫核型进化的因素。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

Meiotic drive against chromosome fusions in butterfly hybrids.

Meiotic drive against chromosome fusions in butterfly hybrids.

Species frequently differ in the number and structure of chromosomes they harbor, but individuals that are heterozygous for chromosomal rearrangements may suffer from reduced fitness. Chromosomal rearrangements like fissions and fusions can hence serve as a mechanism for speciation between incipient lineages, but their evolution poses a paradox. How can rearrangements get fixed between populations if heterozygotes have reduced fitness? One solution is that this process predominantly occurs in small and isolated populations, where genetic drift can override natural selection. However, fixation is also more likely if a novel rearrangement is favored by a transmission bias, such as meiotic drive. Here, we investigate chromosomal transmission distortion in hybrids between two wood white (Leptidea sinapis) butterfly populations with extensive karyotype differences. Using data from two different crossing experiments, we uncover that there is a transmission bias favoring the ancestral chromosomal state for derived fusions, a result that shows that chromosome fusions actually can fix in populations despite being counteracted by meiotic drive. This means that meiotic drive not only can promote runaway chromosome number evolution and speciation, but also that it can be a conservative force acting against karyotypic change and the evolution of reproductive isolation. Based on our results, we suggest a mechanistic model for why chromosome fusion mutations may be opposed by meiotic drive and discuss factors contributing to karyotype evolution in Lepidoptera.

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来源期刊
ACS Applied Bio Materials
ACS Applied Bio Materials Chemistry-Chemistry (all)
CiteScore
9.40
自引率
2.10%
发文量
464
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