Piotr Gabryel, Piotr Skrzypczak, Lidia Szlanga, Aleksandra Kaluzniak-Szymanowska, Magdalena Sielewicz, Alessio Campisi, Magdalena Roszak, Cezary Piwkowski
{"title":"身体脂肪与胸腔镜肺叶切除术治疗肺癌效果的关系--一项单中心队列研究。","authors":"Piotr Gabryel, Piotr Skrzypczak, Lidia Szlanga, Aleksandra Kaluzniak-Szymanowska, Magdalena Sielewicz, Alessio Campisi, Magdalena Roszak, Cezary Piwkowski","doi":"10.5114/kitp.2024.138524","DOIUrl":null,"url":null,"abstract":"<p><strong>Introduction: </strong>The outcomes of lung cancer surgery depend on the patients' nutritional status. Body fat percentage (BF%) is one of the indicators of body composition and nutritional status. Direct measurement of BF% is complicated, requires significant resources and is rarely performed. The CUN-BAE (Clínica Universidad de Navarra - Body Adiposity Estimator) index has been shown to accurately predict BF% is several clinical settings, but its relation to the outcomes of lung surgery has not been reported so far.</p><p><strong>Aim: </strong>To determine the relation of the BF% to the outcomes of thoracoscopic lobectomy.</p><p><strong>Material and methods: </strong>This retrospective study included 1,183 patients who underwent thoracoscopic lobectomy for non-small cell lung cancer between June 1999, and September 2019 at one department. BF% was calculated according to the Clínica Universidad de Navarra - Body Adiposity Estimator equation. The primary endpoints were postoperative complications and long-term survival.</p><p><strong>Results: </strong>Univariate analysis showed that higher BF% was related to lower incidence of complications (<i>p</i> = 0.001), including prolonged air leak (<i>p</i> < 0.001), atelectasis (<i>p</i> < 0.05), psychosis (<i>p</i> < 0.001), reoperations (<i>p</i> < 0.05), and shorter chest drainage (<i>p</i> = 0.001) and hospitalization duration (<i>p</i> < 0.001). Multivariate analysis showed that higher BF% was correlated with lower risk of complications (<i>p</i> = 0.005; OR = 0.964; 95% CI: 0.940 to 0.989), including prolonged air leak (<i>p</i> < 0.001; OR = 0.923; 95% CI: 0.886 to 0.962), and shorter duration of chest drainage (<i>p</i> < 0.001; B = -0.046; 95% CI: -0.069 to -0.023) and hospitalization (<i>p</i> < 0.001; B = -0.112; 95% CI: -0.176 to -0.048). Cox proportional hazards regression analysis showed that BF% was not related to long-term survival.</p><p><strong>Conclusions: </strong>Body fat percentage is a valuable tool that can help predict the short-term outcomes of minimally lobectomy for lung cancer.</p>","PeriodicalId":49945,"journal":{"name":"Kardiochirurgia I Torakochirurgia Polska","volume":"21 1","pages":"8-14"},"PeriodicalIF":0.6000,"publicationDate":"2024-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11059012/pdf/","citationCount":"0","resultStr":"{\"title\":\"The relation of body adiposity to the outcomes of thoracoscopic lobectomy for lung cancer - a single-center cohort study.\",\"authors\":\"Piotr Gabryel, Piotr Skrzypczak, Lidia Szlanga, Aleksandra Kaluzniak-Szymanowska, Magdalena Sielewicz, Alessio Campisi, Magdalena Roszak, Cezary Piwkowski\",\"doi\":\"10.5114/kitp.2024.138524\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Introduction: </strong>The outcomes of lung cancer surgery depend on the patients' nutritional status. Body fat percentage (BF%) is one of the indicators of body composition and nutritional status. Direct measurement of BF% is complicated, requires significant resources and is rarely performed. The CUN-BAE (Clínica Universidad de Navarra - Body Adiposity Estimator) index has been shown to accurately predict BF% is several clinical settings, but its relation to the outcomes of lung surgery has not been reported so far.</p><p><strong>Aim: </strong>To determine the relation of the BF% to the outcomes of thoracoscopic lobectomy.</p><p><strong>Material and methods: </strong>This retrospective study included 1,183 patients who underwent thoracoscopic lobectomy for non-small cell lung cancer between June 1999, and September 2019 at one department. BF% was calculated according to the Clínica Universidad de Navarra - Body Adiposity Estimator equation. The primary endpoints were postoperative complications and long-term survival.</p><p><strong>Results: </strong>Univariate analysis showed that higher BF% was related to lower incidence of complications (<i>p</i> = 0.001), including prolonged air leak (<i>p</i> < 0.001), atelectasis (<i>p</i> < 0.05), psychosis (<i>p</i> < 0.001), reoperations (<i>p</i> < 0.05), and shorter chest drainage (<i>p</i> = 0.001) and hospitalization duration (<i>p</i> < 0.001). Multivariate analysis showed that higher BF% was correlated with lower risk of complications (<i>p</i> = 0.005; OR = 0.964; 95% CI: 0.940 to 0.989), including prolonged air leak (<i>p</i> < 0.001; OR = 0.923; 95% CI: 0.886 to 0.962), and shorter duration of chest drainage (<i>p</i> < 0.001; B = -0.046; 95% CI: -0.069 to -0.023) and hospitalization (<i>p</i> < 0.001; B = -0.112; 95% CI: -0.176 to -0.048). Cox proportional hazards regression analysis showed that BF% was not related to long-term survival.</p><p><strong>Conclusions: </strong>Body fat percentage is a valuable tool that can help predict the short-term outcomes of minimally lobectomy for lung cancer.</p>\",\"PeriodicalId\":49945,\"journal\":{\"name\":\"Kardiochirurgia I Torakochirurgia Polska\",\"volume\":\"21 1\",\"pages\":\"8-14\"},\"PeriodicalIF\":0.6000,\"publicationDate\":\"2024-03-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11059012/pdf/\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Kardiochirurgia I Torakochirurgia Polska\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.5114/kitp.2024.138524\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"2024/3/30 0:00:00\",\"PubModel\":\"Epub\",\"JCR\":\"Q4\",\"JCRName\":\"SURGERY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Kardiochirurgia I Torakochirurgia Polska","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.5114/kitp.2024.138524","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2024/3/30 0:00:00","PubModel":"Epub","JCR":"Q4","JCRName":"SURGERY","Score":null,"Total":0}
引用次数: 0
摘要
导言肺癌手术的效果取决于患者的营养状况。体脂率(BF%)是身体成分和营养状况的指标之一。直接测量体脂率比较复杂,需要大量资源,而且很少进行。CUN-BAE(Clínica Universidad de Navarra - Body Adiposity Estimator,纳瓦拉大学身体脂肪估计器)指数已被证明可在多种临床环境中准确预测体脂率,但其与肺部手术结果的关系迄今尚未见报道:这项回顾性研究纳入了1999年6月至2019年9月期间在一个科室接受胸腔镜肺叶切除术治疗非小细胞肺癌的1183名患者。BF%是根据纳瓦拉大学诊所--身体脂肪估计方程计算得出的。主要终点是术后并发症和长期生存:单变量分析显示,BF%越高,并发症发生率越低(p = 0.001),包括漏气时间延长(p < 0.001)、肺不张(p < 0.05)、精神病(p < 0.001)、再次手术(p < 0.05)、胸腔引流时间缩短(p = 0.001)和住院时间缩短(p < 0.001)。多变量分析显示,较高的 BF% 与较低的并发症风险相关(p = 0.005;OR = 0.964;95% CI:0.940 至 0.989),包括长时间漏气(p < 0.001;OR = 0.923; 95% CI: 0.886 to 0.962),以及较短的胸腔引流时间(P < 0.001; B = -0.046; 95% CI: -0.069 to -0.023)和住院时间(P < 0.001; B = -0.112; 95% CI: -0.176 to -0.048)。Cox比例危险回归分析表明,体脂率与长期生存无关:结论:体脂率是一种有价值的工具,有助于预测肺癌微创肺叶切除术的短期疗效。
The relation of body adiposity to the outcomes of thoracoscopic lobectomy for lung cancer - a single-center cohort study.
Introduction: The outcomes of lung cancer surgery depend on the patients' nutritional status. Body fat percentage (BF%) is one of the indicators of body composition and nutritional status. Direct measurement of BF% is complicated, requires significant resources and is rarely performed. The CUN-BAE (Clínica Universidad de Navarra - Body Adiposity Estimator) index has been shown to accurately predict BF% is several clinical settings, but its relation to the outcomes of lung surgery has not been reported so far.
Aim: To determine the relation of the BF% to the outcomes of thoracoscopic lobectomy.
Material and methods: This retrospective study included 1,183 patients who underwent thoracoscopic lobectomy for non-small cell lung cancer between June 1999, and September 2019 at one department. BF% was calculated according to the Clínica Universidad de Navarra - Body Adiposity Estimator equation. The primary endpoints were postoperative complications and long-term survival.
Results: Univariate analysis showed that higher BF% was related to lower incidence of complications (p = 0.001), including prolonged air leak (p < 0.001), atelectasis (p < 0.05), psychosis (p < 0.001), reoperations (p < 0.05), and shorter chest drainage (p = 0.001) and hospitalization duration (p < 0.001). Multivariate analysis showed that higher BF% was correlated with lower risk of complications (p = 0.005; OR = 0.964; 95% CI: 0.940 to 0.989), including prolonged air leak (p < 0.001; OR = 0.923; 95% CI: 0.886 to 0.962), and shorter duration of chest drainage (p < 0.001; B = -0.046; 95% CI: -0.069 to -0.023) and hospitalization (p < 0.001; B = -0.112; 95% CI: -0.176 to -0.048). Cox proportional hazards regression analysis showed that BF% was not related to long-term survival.
Conclusions: Body fat percentage is a valuable tool that can help predict the short-term outcomes of minimally lobectomy for lung cancer.
期刊介绍:
Polish Journal of Thoracic and Cardiovascular Surgery is a quarterly aimed at cardiologists, cardiosurgeons and thoracic surgeons. Includes the original works (experimental, research and development), illustrative and casuistical works about cardiology and cardiosurgery.