S100A9：连接病毒感染和炎症的非同寻常的嫌疑人

IF 3.6 3区医学 Q2 IMMUNOLOGY

Journal of immunology Pub Date : 2024-05-15 DOI:10.4049/jimmunol.2300640

Julien Boucher, Caroline Gilbert, Santanu Bose, Philippe A Tessier

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引用次数: 0

摘要

自 COVID-19 病毒大流行以来，人们对 S100A9 在病毒感染中的作用越来越感兴趣。研究发现，S100A8/A9 的水平与 COVID-19 疾病的严重程度、细胞因子风暴以及髓系细胞亚群的变化相关。这些数据提出了一个假设：S100A8/A9 蛋白可能在 COVID-19 发病机制中发挥着积极作用。本综述探讨了 S100A8/9 的结构和功能，以及目前有关 S100A8/A9 及其成分参与病毒感染的知识。还讨论了 S100A9 在 SARS-CoV-2 感染中的潜在作用。

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S100A9: The Unusual Suspect Connecting Viral Infection and Inflammation.

The study of S100A9 in viral infections has seen increased interest since the COVID-19 pandemic. S100A8/A9 levels were found to be correlated with the severity of COVID-19 disease, cytokine storm, and changes in myeloid cell subsets. These data led to the hypothesis that S100A8/A9 proteins might play an active role in COVID-19 pathogenesis. This review explores the structures and functions of S100A8/9 and the current knowledge on the involvement of S100A8/A9 and its constituents in viral infections. The potential roles of S100A9 in SARS-CoV-2 infections are also discussed.

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来源期刊

Journal of immunology 医学-免疫学

CiteScore

8.20

自引率

2.30%

发文量

495

审稿时长

1 months

期刊介绍： The JI publishes novel, peer-reviewed findings in all areas of experimental immunology, including innate and adaptive immunity, inflammation, host defense, clinical immunology, autoimmunity and more. Special sections include Cutting Edge articles, Brief Reviews and Pillars of Immunology. The JI is published by The American Association of Immunologists (AAI)