基于酵母的筛选平台，了解并改善人类健康。

IF 14.3 1区工程技术 Q1 BIOTECHNOLOGY & APPLIED MICROBIOLOGY

Trends in biotechnology Pub Date : 2024-10-01 Epub Date: 2024-04-26 DOI:10.1016/j.tibtech.2024.04.003

Marcus Deichmann, Frederik G Hansson, Emil D Jensen

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引用次数: 0

摘要

要开发有效的疗法，就必须对人类机体有详细的分子了解。酵母菌已被广泛用于深入了解人类健康的重要方面，如研究遗传学和细胞-细胞通讯、阐明蛋白质-蛋白质相互作用（PPI）网络以及研究人类 G 蛋白偶联受体（hGPCR）信号传导。我们重点介绍了基于酵母的技术在以下方面的最新进展和机遇：对 hGPCR 进行经济高效的化学文库筛选；通过基于交配的筛选和选择加速解密 PPI 网络；以及与人类免疫细胞进行准确的细胞-细胞通讯。总之，基于酵母的技术是支持基础理解和创新应用以改善人类健康的重要平台。

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Yeast-based screening platforms to understand and improve human health.

Detailed molecular understanding of the human organism is essential to develop effective therapies. Saccharomyces cerevisiae has been used extensively for acquiring insights into important aspects of human health, such as studying genetics and cell-cell communication, elucidating protein-protein interaction (PPI) networks, and investigating human G protein-coupled receptor (hGPCR) signaling. We highlight recent advances and opportunities of yeast-based technologies for cost-efficient chemical library screening on hGPCRs, accelerated deciphering of PPI networks with mating-based screening and selection, and accurate cell-cell communication with human immune cells. Overall, yeast-based technologies constitute an important platform to support basic understanding and innovative applications towards improving human health.

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来源期刊

Trends in biotechnology 工程技术-生物工程与应用微生物

CiteScore

28.60

自引率

1.20%

发文量

198

审稿时长

1 months

期刊介绍： Trends in Biotechnology publishes reviews and perspectives on the applied biological sciences, focusing on useful science applied to, derived from, or inspired by living systems. The major themes that TIBTECH is interested in include: Bioprocessing (biochemical engineering, applied enzymology, industrial biotechnology, biofuels, metabolic engineering) Omics (genome editing, single-cell technologies, bioinformatics, synthetic biology) Materials and devices (bionanotechnology, biomaterials, diagnostics/imaging/detection, soft robotics, biosensors/bioelectronics) Therapeutics (biofabrication, stem cells, tissue engineering and regenerative medicine, antibodies and other protein drugs, drug delivery) Agroenvironment (environmental engineering, bioremediation, genetically modified crops, sustainable development).