医护人员感染 COVID-19 后的高保护率:一项人群观察研究。

IF 1.6 Q2 MEDICINE, GENERAL & INTERNAL
Sepehr Shahriarirad, Naeimehossadat Asmarian, Reza Shahriarirad, Mohsen Moghadami, Mehrdad Askarian, Leila Hashemizadeh Fard Haghighi, Parisa Javadi, Golnar Sabetian
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引用次数: 0

摘要

背景:尽管冠状病毒病 2019(COVID-19)疫情爆发已过去数年,但有关该疾病某些方面的信息(如感染后免疫力)仍然相当有限。本研究旨在评估连续三次疫情暴发期间医护人员的感染后保护和COVID-19特征,以及严重急性呼吸系统综合征冠状病毒2(SARS-CoV-2)再感染率、再激活率、再阳性率和严重程度:这项横断面人群观察研究于 2020 年 4 月 20 日至 2021 年 2 月 18 日进行。研究人群包括伊朗南部法尔斯省公立或私立医院的所有医护人员。感染率的计算方法是聚合酶链反应(PCR)检测呈阳性的人数除以风险人日总数。90 天后对再次感染情况进行评估:共对 30 546 名高危工人进行了聚合酶链反应检测,其中 13 749 人(占高危工人总数的 61.94%)呈阳性。考虑到所采用的 90 天阈值,在 141 例(2.64%)诊断为 COVID-19 的病例中,有 44 例(31.2%)再次活化和复发,97 例(占感染病例的 68.8%,占人机工程工人总数的 1.81%)再次感染。在症状(P=0.65)或入住重症监护室的必要性(P=0.25)方面没有明显差异。结论:SARS-CoV-2再次感染的保护率估计为94.8% (95% CI=93.6-95.7):结论:SARS-CoV-2 再次阳性、复发和再次感染在高危人群中很少见。在首次感染后,估计有 94.8% 的人可避免再次感染。本稿件的预印本可在 DOI:10.21203/rs.3.rs-772662/v1 (https://www.researchsquare.com/article/rs-772662/v1) 上查阅。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
High Post-Infection Protection after COVID-19 among Healthcare Workers: A Population-Level Observational Study.

Background: Even though a few years have passed since the coronavirus disease 2019 (COVID-19) outbreak, information regarding certain aspects of the disease, such as post-infection immunity, is still quite limited. This study aimed to evaluate post-infection protection and COVID-19 features among healthcare workers (HCWs), during three successive surges, as well as the rate of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) reinfection, reactivation, re-positivity, and severity.

Methods: This cross-sectional population-level observational study was conducted from 20 April 2020 to 18 February 2021. The study population included all HCWs in public or private hospitals in Fars Province, Southern Iran. The infection rate was computed as the number of individuals with positive polymerase chain reaction (PCR) tests divided by the total number of person-days at risk. The re-infection was evaluated after 90 days.

Results: A total of 30,546 PCR tests were performed among HCWs, of which 13,749 (61.94% of total HCWs) were positive. Considering the applied 90-day threshold, there were 44 (31.2%) cases of reactivation and relapse, and 97 (68.8% of infected and 1.81% of total HCWs) cases of reinfection among 141 (2.64%) diagnosed cases who experienced a second episode of COVID-19. There was no significant difference in symptoms (P=0.65) or the necessity for ICU admission (P=0.25). The estimated protection against repeated infection after a previous SARS-CoV-2 infection was 94.8% (95% CI=93.6-95.7).

Conclusion: SARS-CoV-2 re-positivity, relapse, and reinfection were rare in the HCW population. After the first episode of infection, an estimated 94.8% protection against recurring infections was achieved. A preprint version of this manuscript is available at DOI:10.21203/rs.3.rs-772662/v1 (https://www.researchsquare.com/article/rs-772662/v1).

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来源期刊
Iranian Journal of Medical Sciences
Iranian Journal of Medical Sciences MEDICINE, GENERAL & INTERNAL-
CiteScore
3.20
自引率
0.00%
发文量
84
审稿时长
12 weeks
期刊介绍: The Iranian Journal of Medical Sciences (IJMS) is an international quarterly biomedical publication, which is sponsored by Shiraz University of Medical Sciences. The IJMS intends to provide a scientific medium of com­muni­cation for researchers throughout the globe. The journal welcomes original clinical articles as well as clinically oriented basic science re­search experiences on prevalent diseases in the region and analysis of various regional problems.
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