手术室的长期消毒会影响医务人员的皮肤微生物群和代谢物。

IF 2.8 4区 医学 Q2 DERMATOLOGY
Skin Pharmacology and Physiology Pub Date : 2024-01-01 Epub Date: 2024-05-06 DOI:10.1159/000539100
Yu Yan, Shuzheng Huang, Yu Zeng, Siyuan Yue, Tong Wang, Lin Yuan, Junhui Nie
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引用次数: 0

摘要

简介:消毒剂通过消除物体表面的微生物,在减少医疗保健相关感染方面发挥着至关重要的作用。然而,长期使用消毒剂可能会对皮肤微生物群产生不利影响,而皮肤微生物群对皮肤健康和预防感染至关重要。本研究调查了消毒对手术室医务人员皮肤微生物群和代谢物的影响,旨在为保障他们的皮肤健康提供科学依据:我们进行了 16S 测序和代谢组学分析,以评估消毒对医务人员皮肤微生物群和代谢物的影响。我们收集了手术室人员接触消毒剂后的样本,以确定微生物群落和代谢物特征的变化:我们的分析表明,长期使用消毒剂会导致皮肤微生物群落和微生物代谢物发生变化。这些改变包括产生有害代谢物,有可能导致医务人员皮肤感染和其他健康问题:研究结果强调了尽量减少长期使用消毒剂对皮肤微生物群和代谢物造成的破坏以保护医务人员整体健康的重要性。这项研究为了解消毒剂的使用、皮肤微生物群和代谢物之间的关系提供了宝贵的见解,突出了在这一领域开展进一步研究的必要性。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Long-Term Disinfection in Operating Rooms Affects Skin Microbiota and Metabolites of Medical Personnel.

Introduction: Disinfectants play a critical role in reducing healthcare-associated infections by eliminating microorganisms on surfaces. However, prolonged use of disinfectants may adversely affect the skin microflora, essential for skin health and infection prevention. This study investigates the impact of disinfection on the skin microbiota and metabolites of medical personnel in operating rooms, aiming to provide a scientific foundation for safeguarding their skin health.

Methods: We conducted 16S sequencing and metabolomic analysis to assess the effects of disinfection on the skin microbiota and metabolites of medical personnel. Samples were collected from operating room personnel after disinfectant exposure to identify changes in microbial communities and metabolite profiles.

Results: Our analysis revealed that prolonged use of disinfectants led to alterations in skin microbial communities and microbial metabolites. These alterations included the production of harmful metabolites that could potentially promote skin infections and other health issues among medical personnel.

Conclusion: The findings underscore the importance of minimizing disruptions to skin microbiota and metabolites caused by long-term disinfectant use to preserve the overall health of medical personnel. This study provides valuable insights into the relationship between disinfectant use, skin microbiota, and metabolites, highlighting the necessity for further research in this area.

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来源期刊
Skin Pharmacology and Physiology
Skin Pharmacology and Physiology 医学-皮肤病学
CiteScore
5.20
自引率
7.40%
发文量
23
审稿时长
>12 weeks
期刊介绍: In the past decade research into skin pharmacology has rapidly developed with new and promising drugs and therapeutic concepts being introduced regularly. Recently, the use of nanoparticles for drug delivery in dermatology and cosmetology has become a topic of intensive research, yielding remarkable and in part surprising results. Another topic of current research is the use of tissue tolerable plasma in wound treatment. Stimulating not only wound healing processes but also the penetration of topically applied substances into the skin, this novel technique is expected to deliver very interesting results.
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