将 TLR 信号通路作为宫颈癌的有望靶点进行探索:少有人走的路

3区 生物学 Q1 Biochemistry, Genetics and Molecular Biology
Mohini Agarwal, Manish Kumar, Rajiv Pathak, Kumud Bala, Anoop Kumar
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引用次数: 0

摘要

宫颈癌是全球妇女因癌症死亡的主要原因。尽管在预防和治疗方面取得了显著进展,但确定新的治疗靶点对宫颈癌仍然至关重要。Toll 样受体(TLRs)作为模式识别受体在先天性免疫中发挥着重要作用。有几种病原体相关分子模式(PAMPs),包括宫颈癌细胞中存在的PAMPs,能够激活收费样受体(TLRs)。最近的研究发现,宫颈癌中的收费样受体(TLR)信号通路失调,导致炎性细胞因子和趋化因子的产生,从而促进肿瘤的生长和转移。因此,TLRs 有望成为宫颈癌创新治疗药物的潜在靶点。本书的这一章探讨了 TLR 信号通路在宫颈癌中的作用,强调了它们在靶向治疗中的潜力,同时也探讨了肿瘤异质性和脱靶效应等挑战。尽管存在这些障碍,但针对 TLR 信号通路开发新型有效的宫颈癌治疗方法前景广阔。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Exploring TLR signaling pathways as promising targets in cervical cancer: The road less traveled.

Cervical cancer is the leading cause of cancer-related deaths for women globally. Despite notable advancements in prevention and treatment, the identification of novel therapeutic targets remains crucial for cervical cancer. Toll-like receptors (TLRs) play an essential role in innate immunity as pattern-recognition receptors. There are several types of pathogen-associated molecular patterns (PAMPs), including those present in cervical cancer cells, which have the ability to activate toll-like receptors (TLRs). Recent studies have revealed dysregulated toll-like receptor (TLR) signaling pathways in cervical cancer, leading to the production of inflammatory cytokines and chemokines that can facilitate tumor growth and metastasis. Consequently, TLRs hold significant promise as potential targets for innovative therapeutic agents against cervical cancer. This book chapter explores the role of TLR signaling pathways in cervical cancer, highlighting their potential for targeted therapy while addressing challenges such as tumor heterogeneity and off-target effects. Despite these obstacles, targeting TLR signaling pathways presents a promising approach for the development of novel and effective treatments for cervical cancer.

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来源期刊
International review of cell and molecular biology
International review of cell and molecular biology BIOCHEMISTRY & MOLECULAR BIOLOGY-CELL BIOLOGY
CiteScore
7.70
自引率
0.00%
发文量
67
审稿时长
>12 weeks
期刊介绍: International Review of Cell and Molecular Biology presents current advances and comprehensive reviews in cell biology-both plant and animal. Articles address structure and control of gene expression, nucleocytoplasmic interactions, control of cell development and differentiation, and cell transformation and growth. Authored by some of the foremost scientists in the field, each volume provides up-to-date information and directions for future research.
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