MASLD 在小鼠体内的翻译过程中丢失了吗？

IF 11.4 1区医学 Q1 ENDOCRINOLOGY & METABOLISM

Trends in Endocrinology and Metabolism Pub Date : 2024-06-01 Epub Date: 2024-04-09 DOI:10.1016/j.tem.2024.03.005

Aysim Gunes, Jennifer L Estall

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引用次数: 0

摘要

缺乏临床前模型转化常常被归咎于药物开发失败。在此，我们结合人类脂肪性肝病（SLD）讨论小鼠模型。衰老和非食物性肝压力源等变量常常被忽视，但它们可以解释在实验室中再现人类疾病所面临的挑战。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Is MASLD lost in translation in mice?

Lack of preclinical model translation is often blamed for failed drug development. Here we discuss mouse models within the context of human steatotic liver disease (SLD). Variables such as aging and non-food hepatic stressors are often ignored but could explain challenges in reproducing the human disease in a laboratory.

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来源期刊

Trends in Endocrinology and Metabolism 医学-内分泌学与代谢

CiteScore

20.10

自引率

0.00%

发文量

审稿时长

82 days

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