通过免疫抑制成功治疗恶性肿瘤诱发的他汀类药物免疫介导坏死性肌病

IF 3.6 4区医学 Q1 MEDICINE, GENERAL & INTERNAL

Clinical Medicine Pub Date : 2024-05-01 Epub Date: 2024-05-06 DOI:10.1016/j.clinme.2024.100217

Ahmed Abouelazm, Kirollos Philops, Amr Amine, Yahia Golam

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引用次数: 0

摘要

他汀类药物诱导的免疫介导坏死性肌病（IMNM）是一种炎症性肌病，可表现为近端肌无力，在某些病例中还可表现为吞咽困难和呼吸窘迫。在本报告中，我们介绍了一例他汀类药物诱发的 IMNM 病例，患者是一名 78 岁的男性。患者入院前 10 个月开始服用 20 毫克剂量的阿托伐他汀，一个月后出现近端肌肉逐渐无力，肌酸激酶和肌红蛋白尿水平明显升高。在使用大剂量糖皮质激素和甲氨蝶呤后，临床症状迅速好转。

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Statin-induced, immune-mediated necrotising myopathy triggered by malignancy successfully treated with immunosuppression.

Statin-induced immune-mediated necrotising myopathy (IMNM) is an inflammatory myopathy that can present as proximal muscle weakness and, in some cases, as dysphagia and respiratory distress. In this report, we present a case of statin-induced IMNM in a 78-year-old male. The patient had significantly high levels of creatinine kinase and myoglobinuria and experienced gradual weakness in the proximal muscles for 1 month after initiating a 20 mg dose of Atorvastatin 10 months before admission. Rapid clinical improvement was observed with the use of high-dose glucocorticoids in conjunction with methotrexate.

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来源期刊

Clinical Medicine 医学-医学：内科

CiteScore

7.20

自引率

0.00%

发文量

审稿时长

6-12 weeks

期刊介绍： Clinical Medicine is aimed at practising physicians in the UK and overseas and has relevance to all those managing or working within the healthcare sector. Available in print and online, the journal seeks to encourage high standards of medical care by promoting good clinical practice through original research, review and comment. The journal also includes a dedicated continuing medical education (CME) section in each issue. This presents the latest advances in a chosen specialty, with self-assessment questions at the end of each topic enabling CPD accreditation to be acquired. ISSN: 1470-2118 E-ISSN: 1473-4893 Frequency: 6 issues per year