结核分枝杆菌核酸疫苗脂质体肺部递送及其作用机制的研究进展。

IF 4.6 Q2 MATERIALS SCIENCE, BIOMATERIALS
ACS Applied Bio Materials Pub Date : 2024-10-01 Epub Date: 2024-04-26 DOI:10.1089/jamp.2023.0025
Danyang Zhang, Haimei Zhao, Ping Li, Xueqiong Wu, Yan Liang
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引用次数: 0

摘要

传统疫苗在预防和治疗传染病方面发挥了重要作用,但仍存在免疫原性低、稳定性差、难以诱导持久免疫应答等问题。近年来,核酸疫苗作为一种相对廉价、安全的新型疫苗应运而生。与传统疫苗相比,核酸疫苗具有易于生产和储存、可规模化生产、批次间一致性好等独特优势。然而,直接注射裸核酸疫苗的效果并不理想,因此需要更安全、更有效的疫苗递送系统。随着纳米载体技术的快速发展,基因治疗与纳米给药系统的结合拓宽了分子生物学的治疗应用和生物纳米材料的医学应用。纳米颗粒可作为潜在的给药载体,用于治疗遗传性和传染性疾病。此外,由于肺部免疫具有起效快、疗效好、不良反应少等优点,核酸疫苗肺部给药已成为该领域的研究热点。近年来,脂质纳米载体因其独特的物理和化学性质成为安全、高效、理想的疫苗递送材料,可有效降低药物的毒副作用,达到缓释、控释的效果,已有大量研究利用脂质纳米载体将靶向成分高效递送到体内。本文以脂质载体递送结核病(TB)核酸疫苗为基础,系统综述了脂质体作为核酸疫苗递送载体的优势和机理,为今后更快、更有效地开发新型抗结核疫苗递送系统奠定坚实的基础。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Research Progress on Liposome Pulmonary Delivery of Mycobacterium tuberculosis Nucleic Acid Vaccine and Its Mechanism of Action.

Traditional vaccines have played an important role in the prevention and treatment of infectious diseases, but they still have problems such as low immunogenicity, poor stability, and difficulty in inducing lasting immune responses. In recent years, the nucleic acid vaccine has emerged as a relatively cheap and safe new vaccine. Compared with traditional vaccines, nucleic acid vaccine has some unique advantages, such as easy production and storage, scalability, and consistency between batches. However, the direct administration of naked nucleic acid vaccine is not ideal, and safer and more effective vaccine delivery systems are needed. With the rapid development of nanocarrier technology, the combination of gene therapy and nanodelivery systems has broadened the therapeutic application of molecular biology and the medical application of biological nanomaterials. Nanoparticles can be used as potential drug-delivery vehicles for the treatment of hereditary and infectious diseases. In addition, due to the advantages of lung immunity, such as rapid onset of action, good efficacy, and reduced adverse reactions, pulmonary delivery of nucleic acid vaccine has become a hot spot in the field of research. In recent years, lipid nanocarriers have become safe, efficient, and ideal materials for vaccine delivery due to their unique physical and chemical properties, which can effectively reduce the toxic side effects of drugs and achieve the effect of slow release and controlled release, and there have been a large number of studies using lipid nanocarriers to efficiently deliver target components into the body. Based on the delivery of tuberculosis (TB) nucleic acid vaccine by lipid carrier, this article systematically reviews the advantages and mechanism of liposomes as a nucleic acid vaccine delivery carrier, so as to lay a solid foundation for the faster and more effective development of new anti-TB vaccine delivery systems in the future.

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来源期刊
ACS Applied Bio Materials
ACS Applied Bio Materials Chemistry-Chemistry (all)
CiteScore
9.40
自引率
2.10%
发文量
464
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