组织细胞和树突状细胞肿瘤的病理特征。

IF 2.3 Q2 HEMATOLOGY
Sun Och Yoon
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引用次数: 0

摘要

组织细胞和树突状细胞肿瘤是由单核吞噬系统(包括单核细胞、巨噬细胞和树突状细胞)产生的多种肿瘤组成。世界卫生组织(WHO)第五版分类法更新了这些肿瘤的分类,反映了人们对其发病机制的更深入了解。滤泡树突状细胞肿瘤被归类为淋巴组织基质衍生肿瘤中的间质树突状细胞肿瘤。组织细胞瘤和树突状细胞瘤的每种亚型都表现出不同的形态学特征,它们还表现出特征性的免疫表型特征,以各种标记物为标志,如 CD1a、CD207/langerin、S100、CD68、CD163、CD4、CD123、CD21、CD23、CD35 和 ALK,以及血淋巴标记物,如 CD45 和 CD43。EBV编码的小RNA(EBER)原位杂交可确定特定的亚型。免疫分型在确定肿瘤的起源细胞和特定亚型方面起着至关重要的作用。这些肿瘤的基因组经常发生改变,尤其是在丝裂原活化蛋白激酶通路中,包括BRAF(尤其是BRAF V600E)、MAP2K1、KRAS和NRAS突变以及ALK基因易位。本综述旨在对组织细胞和树突状细胞肿瘤进行全面的最新概述,重点关注其本体、形态学方面、免疫表型特征和分子遗传学。这种全面的方法对于根据最新的世卫组织分类法准确区分和分类肿瘤至关重要。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Pathologic characteristics of histiocytic and dendritic cell neoplasms.

Histiocytic and dendritic cell neoplasms comprise diverse tumors originating from the mononuclear phagocytic system, which includes monocytes, macrophages, and dendritic cells. The 5th edition of the World Health Organization (WHO) classification updating the categorization of these tumors, reflecting a deeper understanding of their pathogenesis.In this updated classification system, tumors are categorized as Langerhans cell and other dendritic cell neoplasms, histiocyte/macrophage neoplasms, and plasmacytoid dendritic cell neoplasms. Follicular dendritic cell neoplasms are classified as mesenchymal dendritic cell neoplasms within the stroma-derived neoplasms of lymphoid tissues.Each subtype of histiocytic and dendritic cell neoplasms exhibits distinct morphological characteristics. They also show a characteristic immunophenotypic profile marked by various markers such as CD1a, CD207/langerin, S100, CD68, CD163, CD4, CD123, CD21, CD23, CD35, and ALK, and hematolymphoid markers such as CD45 and CD43. In situ hybridization for EBV-encoded small RNA (EBER) identifies a particular subtype. Immunoprofiling plays a critical role in determining the cell of origin and identifying the specific subtype of tumors. There are frequent genomic alterations in these neoplasms, especially in the mitogen-activated protein kinase pathway, including BRAF (notably BRAF V600E), MAP2K1, KRAS, and NRAS mutations, and ALK gene translocation.This review aims to offer a comprehensive and updated overview of histiocytic and dendritic cell neoplasms, focusing on their ontogeny, morphological aspects, immunophenotypic profiles, and molecular genetics. This comprehensive approach is essential for accurately differentiating and classifying neoplasms according to the updated WHO classification.

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来源期刊
Blood Research
Blood Research HEMATOLOGY-
CiteScore
3.70
自引率
0.00%
发文量
64
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