{"title":"11C-蛋氨酸正电子发射断层扫描的最大标准化摄取值可预测口腔鳞状细胞癌患者的预后。","authors":"Takeshi Kuroshima, Yoshimasa Kitagawa, Jun Sato, Shiro Watanabe, Takuya Asaka, Takahiro Abe, Hiroyuki Harada, Kenji Hirata, Yuji Kuge","doi":"10.1007/s10266-024-00946-w","DOIUrl":null,"url":null,"abstract":"<p><p>The present study aimed to elucidate the correlation between the uptake of <sup>11</sup>C-methionine (MET) by a primary tumor and the survival of patients with oral squamous cell carcinoma (OSCC). This study enrolled 31 patients who underwent radical surgery for OSCC. The patients underwent pretreatment MET-positron emission tomography (PET) scanning. We analyzed correlations between the maximum standardized uptake value (SUV<sub>max</sub>) of MET-PET in a primary tumor and the clinicopathological features. Further, we compared overall survival (OS), disease-specific survival (DSS), and loco-regional recurrence (LRR) rates between the two groups according to SUV<sub>max</sub> of MET-PET. SUV<sub>max</sub> of MET-PET in a primary tumor was higher in patients with advanced T-classification and advanced clinical stage, with significant differences (P = 0.001 and P = 0.016, respectively). The patients with SUV<sub>max</sub> of MET-PET ≥ 4.4 showed significantly lower DSS rates and higher LRR rates than those with SUV<sub>max</sub> of < 4.4 (P = 0.015 and P = 0.016, respectively). SUV<sub>max</sub> of MET-PET and OS rates showed no significant correlation (P = 0.073). The present study revealed that SUV<sub>max</sub> of MET-PET may predict clinical outcomes and prognosis in patients with OSCC who underwent radical surgery.</p>","PeriodicalId":19390,"journal":{"name":"Odontology","volume":" ","pages":"372-378"},"PeriodicalIF":1.9000,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Maximum standardized uptake value in <sup>11</sup>C-methionine positron emission tomography may predict the prognosis of patients with oral squamous cell carcinoma.\",\"authors\":\"Takeshi Kuroshima, Yoshimasa Kitagawa, Jun Sato, Shiro Watanabe, Takuya Asaka, Takahiro Abe, Hiroyuki Harada, Kenji Hirata, Yuji Kuge\",\"doi\":\"10.1007/s10266-024-00946-w\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><p>The present study aimed to elucidate the correlation between the uptake of <sup>11</sup>C-methionine (MET) by a primary tumor and the survival of patients with oral squamous cell carcinoma (OSCC). This study enrolled 31 patients who underwent radical surgery for OSCC. The patients underwent pretreatment MET-positron emission tomography (PET) scanning. We analyzed correlations between the maximum standardized uptake value (SUV<sub>max</sub>) of MET-PET in a primary tumor and the clinicopathological features. Further, we compared overall survival (OS), disease-specific survival (DSS), and loco-regional recurrence (LRR) rates between the two groups according to SUV<sub>max</sub> of MET-PET. SUV<sub>max</sub> of MET-PET in a primary tumor was higher in patients with advanced T-classification and advanced clinical stage, with significant differences (P = 0.001 and P = 0.016, respectively). The patients with SUV<sub>max</sub> of MET-PET ≥ 4.4 showed significantly lower DSS rates and higher LRR rates than those with SUV<sub>max</sub> of < 4.4 (P = 0.015 and P = 0.016, respectively). SUV<sub>max</sub> of MET-PET and OS rates showed no significant correlation (P = 0.073). The present study revealed that SUV<sub>max</sub> of MET-PET may predict clinical outcomes and prognosis in patients with OSCC who underwent radical surgery.</p>\",\"PeriodicalId\":19390,\"journal\":{\"name\":\"Odontology\",\"volume\":\" \",\"pages\":\"372-378\"},\"PeriodicalIF\":1.9000,\"publicationDate\":\"2025-01-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Odontology\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.1007/s10266-024-00946-w\",\"RegionNum\":3,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"2024/5/4 0:00:00\",\"PubModel\":\"Epub\",\"JCR\":\"Q2\",\"JCRName\":\"DENTISTRY, ORAL SURGERY & MEDICINE\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Odontology","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1007/s10266-024-00946-w","RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2024/5/4 0:00:00","PubModel":"Epub","JCR":"Q2","JCRName":"DENTISTRY, ORAL SURGERY & MEDICINE","Score":null,"Total":0}
Maximum standardized uptake value in 11C-methionine positron emission tomography may predict the prognosis of patients with oral squamous cell carcinoma.
The present study aimed to elucidate the correlation between the uptake of 11C-methionine (MET) by a primary tumor and the survival of patients with oral squamous cell carcinoma (OSCC). This study enrolled 31 patients who underwent radical surgery for OSCC. The patients underwent pretreatment MET-positron emission tomography (PET) scanning. We analyzed correlations between the maximum standardized uptake value (SUVmax) of MET-PET in a primary tumor and the clinicopathological features. Further, we compared overall survival (OS), disease-specific survival (DSS), and loco-regional recurrence (LRR) rates between the two groups according to SUVmax of MET-PET. SUVmax of MET-PET in a primary tumor was higher in patients with advanced T-classification and advanced clinical stage, with significant differences (P = 0.001 and P = 0.016, respectively). The patients with SUVmax of MET-PET ≥ 4.4 showed significantly lower DSS rates and higher LRR rates than those with SUVmax of < 4.4 (P = 0.015 and P = 0.016, respectively). SUVmax of MET-PET and OS rates showed no significant correlation (P = 0.073). The present study revealed that SUVmax of MET-PET may predict clinical outcomes and prognosis in patients with OSCC who underwent radical surgery.
期刊介绍：
The Journal Odontology covers all disciplines involved in the fields of dentistry and craniofacial research, including molecular studies related to oral health and disease. Peer-reviewed articles cover topics ranging from research on human dental pulp, to comparisons of analgesics in surgery, to analysis of biofilm properties of dental plaque.
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