镰状细胞病患者的血清铁概况及其与社会人口特征和诊断持续时间的关系

Q3 Medicine

Journal of Nepal Health Research Council Pub Date : 2024-03-31 DOI:10.33314/jnhrc.v21i4.4716

Sher Bahadur Kamar, Hemraj Pandey, Shurehraman Puri, Ramesh Shahi, Uttam Bhatta, Sulochana Khadka, Gopal Kumar Yadav, Prativa Subedi, Kapil Amgain

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引用次数: 0

摘要

背景：镰状细胞性贫血是世界上最常见的血红蛋白病：镰状细胞性贫血是世界上最常见的血红蛋白病。本研究旨在评估镰状细胞病患者的铁概况及其与社会人口学特征的关系：方法：以医院为基础开展了一项描述性横断面研究，以了解镰状细胞病患者的铁概况及其与社会人口学特征的关系：平均血清铁、TIBC 和转铁蛋白饱和度分别为 16.75 ± 6.40 mcgMole/L、69.46 ± 16.94 mcg/dl 和 25.15 ± 12.51%。血清铁蛋白介于 10.00 至 3000.00 纳克/毫升之间。血清铁、TIBC、血清铁蛋白和转铁蛋白饱和度正常的参与者比例分别为 86.10%、0.00%、33.90% 和 36.40%。本研究的所有参与者的总铁转换率都偏低（1005），超过一半的参与者血清铁蛋白升高（56.40%）：铁超载是镰状细胞病的常见并发症。结论：铁超载是镰状细胞病的常见并发症，年龄和性别与铁概况无关。乔达利族的 TIBC 与其他族群相比存在差异，这表明铁质状况与种族有关。

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Serum iron Profile of Patients with Sickle Cell Disease and its Association with Socio-demographic Characteristics and Duration of Diagnosis.

Background: Sickle cell anemia is the most common hemoglobinopathy in the world. The study aimed to evaluate the iron profile and its association with socio-demographic characteristics in patients with sickle cell disease.

Methods: A hospital-based descriptive cross-sectional study was conducted to know the iron profile and its socio-demographic association in patients with sickle cell disease.

Results: The average serum iron, TIBC, and transferrin saturation were 16.75 ± 6.40 mcgMole/L, 69.46 ± 16.94 mcg/dl and 25.15 ± 12.51% respectively. The serum ferritin ranged from 10.00 to 3000.00 ng/ml. The proportion of participants with normal serum iron, TIBC, serum ferritin, and transferrin saturation were 86.10%, 0.00%, 33.90% and 36.40% respectively. All of the participants of this study had low TIBC (1005), and more than half of the participants had elevated serum ferritin (56.40%).

Conclusions: Iron overload is a common complication of sickle cell disease. There was no association of age and sex with iron profile. The TIBC variation between the Chaudhary ethnic group compared to other ethnic groups signifies the ethnic role in the iron profile.

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来源期刊

Journal of Nepal Health Research Council Medicine-Medicine (all)

CiteScore

1.40

自引率

0.00%

发文量

审稿时长

15 weeks

期刊介绍： The journal publishes articles related to researches done in the field of biomedical sciences related to all the discipline of the medical sciences, medical education, public health, health care management, including ethical and social issues pertaining to health. The journal gives preference to clinically oriented studies over experimental and animal studies. The Journal would publish peer-reviewed original research papers, case reports, systematic reviews and meta-analysis. Editorial, Guest Editorial, Viewpoint and letter to the editor are solicited by the editorial board. Frequently Asked Questions (FAQ) regarding manuscript submission and processing at JNHRC.