胎儿胰岛素分泌过多与胰岛素抵抗的关系。

IF 11.4 1区医学 Q1 ENDOCRINOLOGY & METABOLISM

Trends in Endocrinology and Metabolism Pub Date : 2024-11-01 Epub Date: 2024-05-01 DOI:10.1016/j.tem.2024.04.008

Christopher J Nolan, Gernot Desoye

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引用次数: 0

摘要

在与肥胖相关的 2 型糖尿病（T2D）中，胰岛素分泌过多和胰岛素抵抗哪一个是上游因素是一个难题。在此，我们探讨了糖尿病母亲胎儿胰岛素分泌和作用的动态变化。我们认为，胎儿胰岛素分泌过多首先发生，而胰岛素抵抗是一种适应性保护反应。

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Disentangling fetal insulin hypersecretion and insulin resistance.

Disentangling which of insulin hypersecretion and insulin resistance is upstream in obesity-related type 2 diabetes (T2D) is challenging. Here, we consider the dynamics of insulin secretion and action in the fetuses of mothers with diabetes. We argue that fetal insulin hypersecretion occurs first, with insulin resistance being an adaptive protective response.

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来源期刊

Trends in Endocrinology and Metabolism 医学-内分泌学与代谢

CiteScore

20.10

自引率

0.00%

发文量

审稿时长

82 days

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