Alice Di Paolo, Valentina Membrino, Sonila Alia, Laura Nanetti, Lucia Emanuela Svarca, Massimo Leone Perrone, Luca Aquilanti, Laura Mazzanti, Arianna Vignini, Eleonora Salvolini, Michele Severini
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To reach our purpose, we assessed eating-related psychopathology and depressive symptoms and measured serum concentration of pro-inflammatory cytokines IL-1β, IL-6, IL-8, and TNF-α before and after 6 months of integrated therapy (which included psychopharmacotherapy, psychotherapy, and nutritional treatment), to define whether selected pro-inflammatory cytokines could be considered a pathophysiological marker of the disorder. A sample of 16 young female patients with early diagnosis of AN, and without any previous treatment, and 22 healthy controls matched by age, sex, and socioeconomic status were enrolled. After 6 months of integrated therapy, a significant decrease of all selected pro-inflammatory cytokines was detected. In addition, an improvement in the anxiety-depressant aspects was also noted. In conclusion, the results obtained suggest that pro-inflammatory cytokines are indeed related to the pathophysiology of AN. However, further investigations, involving larger samples of patients with distinct subtypes of AN, are essential to confirm the current findings.</p>","PeriodicalId":16112,"journal":{"name":"Journal of Investigative Medicine","volume":" ","pages":"522-531"},"PeriodicalIF":2.5000,"publicationDate":"2024-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Pro-inflammatory cytokine alterations in recent onset anorexia nervosa adolescent female patients before and after 6 months of integrated therapy: A case-control study.\",\"authors\":\"Alice Di Paolo, Valentina Membrino, Sonila Alia, Laura Nanetti, Lucia Emanuela Svarca, Massimo Leone Perrone, Luca Aquilanti, Laura Mazzanti, Arianna Vignini, Eleonora Salvolini, Michele Severini\",\"doi\":\"10.1177/10815589241251702\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><p>Anorexia nervosa (AN) is a complex disorder affecting mainly, but not only, teenagers. 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引用次数: 0
摘要
神经性厌食症(AN)是一种复杂的疾病,主要影响青少年,但并不局限于青少年。研究人员一致认为,神经性厌食症与免疫系统受损后的促炎症状态密切相关,这种状态是由 IL-1β 和 TNF-α 等细胞因子水平的改变造成的,同时也受到频繁抑郁状态的影响。因此,本病例对照研究的目的是评估接受专业进食障碍(ED)治疗的 AN 患者与促炎细胞因子之间的关系。为了达到研究目的,我们对进食相关的精神病理学和抑郁症状进行了评估,并在接受综合治疗(包括精神药物治疗、心理治疗和营养治疗)6个月前后测量了促炎细胞因子IL-1β、IL-6、IL-8和TNF-α的血清浓度,以确定某些促炎细胞因子是否可被视为进食障碍的病理生理标志物。研究人员选取了16名早期诊断为自闭症且未接受过任何治疗的年轻女性患者,以及22名年龄、性别和社会经济状况相匹配的健康对照者。经过 6 个月的综合治疗后,所有选定的促炎细胞因子均明显减少。此外,焦虑抑郁方面也有所改善。总之,研究结果表明,促炎细胞因子确实与自闭症的病理生理学有关。然而,为了证实目前的研究结果,有必要对不同亚型的AN患者进行更大规模的调查。
Pro-inflammatory cytokine alterations in recent onset anorexia nervosa adolescent female patients before and after 6 months of integrated therapy: A case-control study.
Anorexia nervosa (AN) is a complex disorder affecting mainly, but not only, teenagers. Researchers agree that AN is deeply associated with a pro-inflammatory state following an impaired immune system, resulting from altered levels of cytokines such as IL-1β and TNF-α, also impacted by the frequent depressive states. Thus, this case-control study aimed to evaluate the relationship between patients suffering from AN undergoing specialized eating disorder treatment for AN and pro-inflammatory cytokines. To reach our purpose, we assessed eating-related psychopathology and depressive symptoms and measured serum concentration of pro-inflammatory cytokines IL-1β, IL-6, IL-8, and TNF-α before and after 6 months of integrated therapy (which included psychopharmacotherapy, psychotherapy, and nutritional treatment), to define whether selected pro-inflammatory cytokines could be considered a pathophysiological marker of the disorder. A sample of 16 young female patients with early diagnosis of AN, and without any previous treatment, and 22 healthy controls matched by age, sex, and socioeconomic status were enrolled. After 6 months of integrated therapy, a significant decrease of all selected pro-inflammatory cytokines was detected. In addition, an improvement in the anxiety-depressant aspects was also noted. In conclusion, the results obtained suggest that pro-inflammatory cytokines are indeed related to the pathophysiology of AN. However, further investigations, involving larger samples of patients with distinct subtypes of AN, are essential to confirm the current findings.
期刊介绍:
Journal of Investigative Medicine (JIM) is the official publication of the American Federation for Medical Research. The journal is peer-reviewed and publishes high-quality original articles and reviews in the areas of basic, clinical, and translational medical research.
JIM publishes on all topics and specialty areas that are critical to the conduct of the entire spectrum of biomedical research: from the translation of clinical observations at the bedside, to basic and animal research to clinical research and the implementation of innovative medical care.