伊朗东部亚兹德接受血管造影术患者的胆固醇酯转移蛋白 Taq1B 多态性及其与心血管风险因素的关系：一项横断面研究

IF 1.6 Q2 MEDICINE, GENERAL & INTERNAL

Iranian Journal of Medical Sciences Pub Date : 2024-04-01 DOI:10.30476/ijms.2023.98201.3012

Azam Ahmadi-Vasmehjani, Seyed Mostafa SeyedHosseini, Sayyed Saeid Khayyatzadeh, Farzan Madadizadeh, Mahta Mazaheri-Naeini, Mahdie Yavari, Zahra Darabi, Sara Beigrezaei, Marzieh Taftian, Vahid Arabi, Maryam Motallaei, Amin Salehi-Abargouei, Azadeh Nadjarzadeh

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引用次数: 0

摘要

背景：多项研究评估了胆固醇酯转移蛋白（CETP）Taq1B 基因多态性（rs708272）与心血管疾病（CVDs）风险因素之间的关系。然而，他们的研究结果并不一致。本研究调查了接受冠状动脉造影术的患者的心血管疾病风险因素与 Taq1B 变异之间的关系：这项横断面研究的对象是 2020-2021 年期间在亚兹德（伊朗）接受冠状动脉造影术的 476 名年龄在 30-76 岁之间的男女患者。使用聚合酶链式反应-限制性片段长度多态性（PCR-RFLP）对从全血中提取的 DNA 进行 Taq1B 多态性基因型评估。测量心血管代谢指标时采用了标准方案。为确定心血管疾病风险因素与 rs708272 变异之间的关联，在粗略模型和调整模型中使用了二元逻辑回归法：Taq1B多态性基因型频率分别为：B1B1 10.7%、B1B2 72.3%、B2B2 17%。心血管疾病危险因素的异常水平与 Taq1B 变体的不同基因型、Gensini 评分（P=0.64）、Syntax 评分（P=0.79）、收缩压（P=0.55）、舒张压（P=0.58）和腰围（P=0.79）之间无明显关联。rs708272 变异基因型与任何血清脂质水平异常之间均无明显关联。在对混杂因素进行调整后，结果仍然不显著：结论：心血管疾病风险因素与 CETP rs708272 多态性之间没有明显关联。CETP基因变异与心血管疾病发生率之间的关系在不同群体中存在差异，这意味着需要在不同地区开展更多研究。本稿件的预印本可在 https://www.researchsquare.com/article/rs-2575215/v1 上查阅，doi: 10.21203/rs.3.rs-2575215/v1。

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Cholesterol Ester Transfer Protein Taq1B Polymorphism and Its Association with Cardiovascular Risk Factors in Patients Undergoing Angiography in Yazd, Eastern Iran: A Cross-Sectional Study.

Background: Several studies assessed the relationship between the cholesterol ester transfer protein (CETP) Taq1B gene polymorphism (rs708272) with risk factors of cardiovascular diseases (CVDs). However, their findings were inconsistent. The present study investigated the relationship between CVD risk factors and the Taq1B variant in patients undergoing coronary angiography.

Methods: This cross-sectional study was conducted on 476 patients aged 30-76 years old of both sexes from 2020-2021, in Yazd (Iran). The Taq1B polymorphism genotypes were evaluated using polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) on DNA extracted from whole blood. Standard protocols were used to measure cardio-metabolic markers. To determine the association between CVDs risk factors and the rs708272 variant, binary logistic regression was used in crude and adjusted models.

Results: Taq1B polymorphism genotype frequencies were 10.7% for B1B1, 72.3% for B1B2, and 17% for B2B2. There was no significant association between abnormal levels of CVDs risk factors and different genotypes of the Taq1B variant, Gensini score (P=0.64), Syntax score (P=0.79), systolic blood pressure (P=0.55), diastolic blood pressure (P=0.58), and waist circumference (P=0.79). There was no significant association between genotypes of the rs708272 variant and any abnormal serum lipid levels. After adjusting for confounders, the results remained non-significant.

Conclusion: There was no significant association between CVDs risk factors and CETP rs708272 polymorphism. The relationship between CETP gene variants and CVD occurrences varied across groups, implying that more research in different regions is required.A preprint version of this manuscript is available at https://www.researchsquare.com/article/rs-2575215/v1 with doi: 10.21203/rs.3.rs-2575215/v1.

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来源期刊

Iranian Journal of Medical Sciences MEDICINE, GENERAL & INTERNAL-

CiteScore

3.20

自引率

0.00%

发文量

审稿时长

12 weeks

期刊介绍： The Iranian Journal of Medical Sciences (IJMS) is an international quarterly biomedical publication, which is sponsored by Shiraz University of Medical Sciences. The IJMS intends to provide a scientific medium of communication for researchers throughout the globe. The journal welcomes original clinical articles as well as clinically oriented basic science research experiences on prevalent diseases in the region and analysis of various regional problems.