使用大麻与胃食管反流病患者并发症的关系:来自全国住院病人样本的启示。

IF 3.1 4区 医学 Q2 PHARMACOLOGY & PHARMACY
Cannabis and Cannabinoid Research Pub Date : 2025-04-01 Epub Date: 2024-05-03 DOI:10.1089/can.2024.0011
Avneet Kaur, Ishandeep Singh, Isha Kohli, Sahiljot Singh Bhupal, Jay Patel, Nikki Nikzad, Aalam Sohal, Juliana Yang
{"title":"使用大麻与胃食管反流病患者并发症的关系:来自全国住院病人样本的启示。","authors":"Avneet Kaur, Ishandeep Singh, Isha Kohli, Sahiljot Singh Bhupal, Jay Patel, Nikki Nikzad, Aalam Sohal, Juliana Yang","doi":"10.1089/can.2024.0011","DOIUrl":null,"url":null,"abstract":"<p><p><b>Background/Objective:</b> Cannabis, one of the most widely used recreational drug in the United States, has had a significant surge in usage following its legalization in 1996. In recent years, there has been research into the physiological effects of cannabis on the gastrointestinal (GI) system. Our study aims to systematically examine the association between cannabis use and complications of gastroesophageal reflux disease (GERD). <b>Materials and Methods:</b> We queried the 2016-2020 National Inpatient Sample database to identify patient encounters with GERD. Patients with eosinophilic esophagitis or missing demographics were excluded. We compared patient demographics, comorbidities, and complications among cannabis users and nonusers. Multivariate logistic regression analysis was used to investigate the relationship between cannabis use and complications of GERD. <b>Results:</b> A total of 27.2 million patient encounters were included in the analysis, out of which 507,190 were cannabis users. Majority of the cannabis users were aged between 45-64 years (46.6%), males (57.4%), White (63.84%), and belonged to the lowest income quartile (40.6%). Cannabis users demonstrated a higher prevalence of esophagitis compared to nonusers (6.11% vs. 3.23%, <i>p</i><0.001). However, they exhibited a lower rates of esophageal stricture (0.6% vs. 0.8%, <i>p</i><0.001) and esophageal cancer (0.2% vs. 0.24%, <i>p</i><0.001). After adjusting for confounding factors, cannabis users were noted to have higher odds of esophagitis (adjusted odds ratio [aOR]: 1.34, 95% confidence interval [CI]: 1.30-1.39, <i>p</i><0.001). A lower odds of esophageal stricture (aOR: 0.88, 95% CI: 0.81-0.96, <i>p</i>=0.02) and esophageal cancer (aOR: 0.48,95% CI: 0.42-0.57, <i>p</i><0.001) were noted. <b>Conclusion:</b> Our cross-sectional study using the nationally available database indicates an association between cannabis use and higher odds of esophagitis, along with lower odds of esophageal stricture and cancer. While these findings suggest a potential relationship between cannabis use and esophageal complications, it is limited in establishing causality. Therefore, further long-term studies are warranted to understand the mechanism behind this association and to determine if cannabis use has an impact on esophagus.</p>","PeriodicalId":9386,"journal":{"name":"Cannabis and Cannabinoid Research","volume":" ","pages":"e333-e340"},"PeriodicalIF":3.1000,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Association of Cannabis Use with Complications Among Patients with Gastroesophageal Reflux Disease: Insights from National Inpatient Sample.\",\"authors\":\"Avneet Kaur, Ishandeep Singh, Isha Kohli, Sahiljot Singh Bhupal, Jay Patel, Nikki Nikzad, Aalam Sohal, Juliana Yang\",\"doi\":\"10.1089/can.2024.0011\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><p><b>Background/Objective:</b> Cannabis, one of the most widely used recreational drug in the United States, has had a significant surge in usage following its legalization in 1996. In recent years, there has been research into the physiological effects of cannabis on the gastrointestinal (GI) system. Our study aims to systematically examine the association between cannabis use and complications of gastroesophageal reflux disease (GERD). <b>Materials and Methods:</b> We queried the 2016-2020 National Inpatient Sample database to identify patient encounters with GERD. Patients with eosinophilic esophagitis or missing demographics were excluded. We compared patient demographics, comorbidities, and complications among cannabis users and nonusers. Multivariate logistic regression analysis was used to investigate the relationship between cannabis use and complications of GERD. <b>Results:</b> A total of 27.2 million patient encounters were included in the analysis, out of which 507,190 were cannabis users. Majority of the cannabis users were aged between 45-64 years (46.6%), males (57.4%), White (63.84%), and belonged to the lowest income quartile (40.6%). Cannabis users demonstrated a higher prevalence of esophagitis compared to nonusers (6.11% vs. 3.23%, <i>p</i><0.001). However, they exhibited a lower rates of esophageal stricture (0.6% vs. 0.8%, <i>p</i><0.001) and esophageal cancer (0.2% vs. 0.24%, <i>p</i><0.001). After adjusting for confounding factors, cannabis users were noted to have higher odds of esophagitis (adjusted odds ratio [aOR]: 1.34, 95% confidence interval [CI]: 1.30-1.39, <i>p</i><0.001). A lower odds of esophageal stricture (aOR: 0.88, 95% CI: 0.81-0.96, <i>p</i>=0.02) and esophageal cancer (aOR: 0.48,95% CI: 0.42-0.57, <i>p</i><0.001) were noted. <b>Conclusion:</b> Our cross-sectional study using the nationally available database indicates an association between cannabis use and higher odds of esophagitis, along with lower odds of esophageal stricture and cancer. While these findings suggest a potential relationship between cannabis use and esophageal complications, it is limited in establishing causality. Therefore, further long-term studies are warranted to understand the mechanism behind this association and to determine if cannabis use has an impact on esophagus.</p>\",\"PeriodicalId\":9386,\"journal\":{\"name\":\"Cannabis and Cannabinoid Research\",\"volume\":\" \",\"pages\":\"e333-e340\"},\"PeriodicalIF\":3.1000,\"publicationDate\":\"2025-04-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Cannabis and Cannabinoid Research\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.1089/can.2024.0011\",\"RegionNum\":4,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"2024/5/3 0:00:00\",\"PubModel\":\"Epub\",\"JCR\":\"Q2\",\"JCRName\":\"PHARMACOLOGY & PHARMACY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Cannabis and Cannabinoid Research","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1089/can.2024.0011","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2024/5/3 0:00:00","PubModel":"Epub","JCR":"Q2","JCRName":"PHARMACOLOGY & PHARMACY","Score":null,"Total":0}
引用次数: 0

摘要

背景/目的:大麻是美国使用最广泛的娱乐性药物之一,自 1996 年合法化以来,其使用量激增。近年来,人们开始研究大麻对胃肠(GI)系统的生理影响。我们的研究旨在系统研究吸食大麻与胃食管反流病(GERD)并发症之间的关联。材料与方法:我们查询了 2016-2020 年全国住院患者样本数据库,以确定胃食管反流病患者的就诊情况。排除了嗜酸性粒细胞食管炎患者或人口统计数据缺失的患者。我们比较了大麻使用者和非使用者的人口统计学特征、合并症和并发症。我们使用多变量逻辑回归分析来研究使用大麻与胃食管反流并发症之间的关系。结果:共有 2720 万次患者就诊被纳入分析,其中 507190 人为大麻使用者。大部分大麻使用者的年龄在 45-64 岁之间(46.6%),男性(57.4%),白人(63.84%),属于收入最低的四分位数(40.6%)。与不吸食者相比,吸食大麻者患食管炎(6.11% vs. 3.23%,ppppp=0.02)和食管癌(aOR:0.48,95% CI:0.42-0.57,pConclusion)的比例更高:我们利用全国可用数据库进行的横断面研究表明,吸食大麻与食管炎发病几率较高以及食管狭窄和癌症发病几率较低之间存在关联。虽然这些研究结果表明吸食大麻与食管并发症之间存在潜在关系,但在确定因果关系方面还很有限。因此,有必要开展进一步的长期研究,以了解这种关联背后的机制,并确定吸食大麻是否会对食道产生影响。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Association of Cannabis Use with Complications Among Patients with Gastroesophageal Reflux Disease: Insights from National Inpatient Sample.

Background/Objective: Cannabis, one of the most widely used recreational drug in the United States, has had a significant surge in usage following its legalization in 1996. In recent years, there has been research into the physiological effects of cannabis on the gastrointestinal (GI) system. Our study aims to systematically examine the association between cannabis use and complications of gastroesophageal reflux disease (GERD). Materials and Methods: We queried the 2016-2020 National Inpatient Sample database to identify patient encounters with GERD. Patients with eosinophilic esophagitis or missing demographics were excluded. We compared patient demographics, comorbidities, and complications among cannabis users and nonusers. Multivariate logistic regression analysis was used to investigate the relationship between cannabis use and complications of GERD. Results: A total of 27.2 million patient encounters were included in the analysis, out of which 507,190 were cannabis users. Majority of the cannabis users were aged between 45-64 years (46.6%), males (57.4%), White (63.84%), and belonged to the lowest income quartile (40.6%). Cannabis users demonstrated a higher prevalence of esophagitis compared to nonusers (6.11% vs. 3.23%, p<0.001). However, they exhibited a lower rates of esophageal stricture (0.6% vs. 0.8%, p<0.001) and esophageal cancer (0.2% vs. 0.24%, p<0.001). After adjusting for confounding factors, cannabis users were noted to have higher odds of esophagitis (adjusted odds ratio [aOR]: 1.34, 95% confidence interval [CI]: 1.30-1.39, p<0.001). A lower odds of esophageal stricture (aOR: 0.88, 95% CI: 0.81-0.96, p=0.02) and esophageal cancer (aOR: 0.48,95% CI: 0.42-0.57, p<0.001) were noted. Conclusion: Our cross-sectional study using the nationally available database indicates an association between cannabis use and higher odds of esophagitis, along with lower odds of esophageal stricture and cancer. While these findings suggest a potential relationship between cannabis use and esophageal complications, it is limited in establishing causality. Therefore, further long-term studies are warranted to understand the mechanism behind this association and to determine if cannabis use has an impact on esophagus.

求助全文
通过发布文献求助,成功后即可免费获取论文全文。 去求助
来源期刊
Cannabis and Cannabinoid Research
Cannabis and Cannabinoid Research PHARMACOLOGY & PHARMACY-
CiteScore
6.80
自引率
7.90%
发文量
164
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
确定
请完成安全验证×
copy
已复制链接
快去分享给好友吧!
我知道了
右上角分享
点击右上角分享
0
联系我们:info@booksci.cn Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术官方微信