{"title":"全身免疫炎症指数和全身炎症反应指数与牙周炎有关：来自 2009 年至 2014 年国家健康调查（NHANES）的证据。","authors":"","doi":"10.1016/j.identj.2024.03.019","DOIUrl":null,"url":null,"abstract":"<div><h3>Introduction and aims</h3><p>Periodontitis, a chronic inflammatory condition affecting the supporting structures of the teeth, is a substantial public health burrden whilst impacting the life quality of those affected. Elevated levels of systemic immune-inflammation index (SII) and systemic inflammation response index (SIRI) have been implicated in various inflammatory conditions. This study aimed to investigate the relationship between SII and SIRI with periodontitis.</p></div><div><h3>Methods</h3><p>The study examined a total of 8666 participants in the 2009 to 2014 National Health and Nutrition Examination Survey (NHANES). The study compared the weighted prevalence of periodontitis among various groups. The association between SII, SIRI levels, and periodontitis was analyzed using binary logistic regression. Additionally, we explored nonlinear relationships between SII, SIRI, and the prevalence of periodontitis using restricted cubic spline (RCS) plots.</p></div><div><h3>Results</h3><p>Among participants in the fourth quartile (Q4) of SII and SIRI, the highest prevalence of periodontitis was observed, with rates of 44.87% and 48.41%, respectively. After adjusting for all covariates, the odds ratio (OR) for periodontitis associated with SII Q4 was 1.19 (95% CI 1.02, 1.39, <em>P</em> = .03), while for SIRI Q4, it was 1.18 (95% CI 1.01, 1.39, <em>P</em> = .04). In addition, the results of sensitivity analysis revealed consistent findings, indicating that after adjusting for all covariates, the OR for periodontitis associated with SII Q4 and SIRI Q4 remained statistically significant. Specifically, the OR for periodontitis associated with SII Q4 was 1.19 (95% CI 1.02, 1.39, <em>P</em> = .03), while for SIRI Q4, it was 1.19 (95% CI 1.01, 1.40, <em>P</em> = .04).</p></div><div><h3>Conclusions</h3><p>These results indicate that elevated SII and SIRI levels are associated with an increased prevalence of periodontitis.</p></div><div><h3>Clinical relevance</h3><p>These findings suggest a potential connection between systemic inflammation and periodontitis, highlighting the importance of periodontitis patients being aware of their systemic diseases that are inflammatory in nature such as chronic cardiovascular afflictions.</p></div>","PeriodicalId":13785,"journal":{"name":"International dental journal","volume":null,"pages":null},"PeriodicalIF":3.2000,"publicationDate":"2024-04-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S0020653924001047/pdfft?md5=6e6905c43d3f5efc89bd7cbb79d74cae&pid=1-s2.0-S0020653924001047-main.pdf","citationCount":"0","resultStr":"{\"title\":\"Systemic Immune-Inflammation Index and Systemic Inflammation Response Index are Associated With Periodontitis: Evidence From NHANES 2009 to 2014\",\"authors\":\"\",\"doi\":\"10.1016/j.identj.2024.03.019\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><h3>Introduction and aims</h3><p>Periodontitis, a chronic inflammatory condition affecting the supporting structures of the teeth, is a substantial public health burrden whilst impacting the life quality of those affected. Elevated levels of systemic immune-inflammation index (SII) and systemic inflammation response index (SIRI) have been implicated in various inflammatory conditions. This study aimed to investigate the relationship between SII and SIRI with periodontitis.</p></div><div><h3>Methods</h3><p>The study examined a total of 8666 participants in the 2009 to 2014 National Health and Nutrition Examination Survey (NHANES). The study compared the weighted prevalence of periodontitis among various groups. The association between SII, SIRI levels, and periodontitis was analyzed using binary logistic regression. Additionally, we explored nonlinear relationships between SII, SIRI, and the prevalence of periodontitis using restricted cubic spline (RCS) plots.</p></div><div><h3>Results</h3><p>Among participants in the fourth quartile (Q4) of SII and SIRI, the highest prevalence of periodontitis was observed, with rates of 44.87% and 48.41%, respectively. After adjusting for all covariates, the odds ratio (OR) for periodontitis associated with SII Q4 was 1.19 (95% CI 1.02, 1.39, <em>P</em> = .03), while for SIRI Q4, it was 1.18 (95% CI 1.01, 1.39, <em>P</em> = .04). In addition, the results of sensitivity analysis revealed consistent findings, indicating that after adjusting for all covariates, the OR for periodontitis associated with SII Q4 and SIRI Q4 remained statistically significant. Specifically, the OR for periodontitis associated with SII Q4 was 1.19 (95% CI 1.02, 1.39, <em>P</em> = .03), while for SIRI Q4, it was 1.19 (95% CI 1.01, 1.40, <em>P</em> = .04).</p></div><div><h3>Conclusions</h3><p>These results indicate that elevated SII and SIRI levels are associated with an increased prevalence of periodontitis.</p></div><div><h3>Clinical relevance</h3><p>These findings suggest a potential connection between systemic inflammation and periodontitis, highlighting the importance of periodontitis patients being aware of their systemic diseases that are inflammatory in nature such as chronic cardiovascular afflictions.</p></div>\",\"PeriodicalId\":13785,\"journal\":{\"name\":\"International dental journal\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":3.2000,\"publicationDate\":\"2024-04-30\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://www.sciencedirect.com/science/article/pii/S0020653924001047/pdfft?md5=6e6905c43d3f5efc89bd7cbb79d74cae&pid=1-s2.0-S0020653924001047-main.pdf\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"International dental journal\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S0020653924001047\",\"RegionNum\":3,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q1\",\"JCRName\":\"DENTISTRY, ORAL SURGERY & MEDICINE\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"International dental journal","FirstCategoryId":"3","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S0020653924001047","RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"DENTISTRY, ORAL SURGERY & MEDICINE","Score":null,"Total":0}
引用次数: 0
摘要
引言和目的：牙周炎是一种影响牙齿支撑结构的慢性炎症，是一个严重的公共卫生问题，同时也影响着患者的生活质量。全身免疫炎症指数（SII）和全身炎症反应指数（SIRI）水平的升高与各种炎症状况有关。本研究旨在探讨 SII 和 SIRI 与牙周炎之间的关系：该研究调查了 2009 年至 2014 年全国健康与营养调查（NHANES）中的 8666 名参与者。研究比较了不同群体牙周炎的加权患病率。使用二元逻辑回归分析了SII、SIRI水平与牙周炎之间的关联。此外，我们还使用限制性三次样条曲线（RCS）图探讨了 SII、SIRI 和牙周炎患病率之间的非线性关系：在 SII 和 SIRI 处于第四四分位数（Q4）的参与者中，牙周炎的患病率最高，分别为 44.87% 和 48.41%。调整所有协变量后，与 SII Q4 相关的牙周炎几率比（OR）为 1.19（95% CI 1.02，1.39，P = .03），而与 SIRI Q4 相关的几率比（OR）为 1.18（95% CI 1.01，1.39，P = .04）。此外，敏感性分析结果显示出一致的结论，即在调整所有协变量后，与 SII Q4 和 SIRI Q4 相关的牙周炎 OR 仍具有显著的统计学意义。具体来说，与 SII Q4 相关的牙周炎 OR 为 1.19（95% CI 1.02，1.39，P = .03），而与 SIRI Q4 相关的牙周炎 OR 为 1.19（95% CI 1.01，1.40，P = .04）：这些结果表明，SII 和 SIRI 水平的升高与牙周炎患病率的增加有关：这些研究结果表明，全身炎症与牙周炎之间存在潜在联系，突出了牙周炎患者了解其全身炎症性疾病（如慢性心血管疾病）的重要性。
Systemic Immune-Inflammation Index and Systemic Inflammation Response Index are Associated With Periodontitis: Evidence From NHANES 2009 to 2014
Introduction and aims
Periodontitis, a chronic inflammatory condition affecting the supporting structures of the teeth, is a substantial public health burrden whilst impacting the life quality of those affected. Elevated levels of systemic immune-inflammation index (SII) and systemic inflammation response index (SIRI) have been implicated in various inflammatory conditions. This study aimed to investigate the relationship between SII and SIRI with periodontitis.
Methods
The study examined a total of 8666 participants in the 2009 to 2014 National Health and Nutrition Examination Survey (NHANES). The study compared the weighted prevalence of periodontitis among various groups. The association between SII, SIRI levels, and periodontitis was analyzed using binary logistic regression. Additionally, we explored nonlinear relationships between SII, SIRI, and the prevalence of periodontitis using restricted cubic spline (RCS) plots.
Results
Among participants in the fourth quartile (Q4) of SII and SIRI, the highest prevalence of periodontitis was observed, with rates of 44.87% and 48.41%, respectively. After adjusting for all covariates, the odds ratio (OR) for periodontitis associated with SII Q4 was 1.19 (95% CI 1.02, 1.39, P = .03), while for SIRI Q4, it was 1.18 (95% CI 1.01, 1.39, P = .04). In addition, the results of sensitivity analysis revealed consistent findings, indicating that after adjusting for all covariates, the OR for periodontitis associated with SII Q4 and SIRI Q4 remained statistically significant. Specifically, the OR for periodontitis associated with SII Q4 was 1.19 (95% CI 1.02, 1.39, P = .03), while for SIRI Q4, it was 1.19 (95% CI 1.01, 1.40, P = .04).
Conclusions
These results indicate that elevated SII and SIRI levels are associated with an increased prevalence of periodontitis.
Clinical relevance
These findings suggest a potential connection between systemic inflammation and periodontitis, highlighting the importance of periodontitis patients being aware of their systemic diseases that are inflammatory in nature such as chronic cardiovascular afflictions.
期刊介绍：
The International Dental Journal features peer-reviewed, scientific articles relevant to international oral health issues, as well as practical, informative articles aimed at clinicians.
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