胸腺细胞的迁移和移出

IF 3.3 4区 医学 Q3 IMMUNOLOGY
Qingyue Tong , Liyu Yao , Mengting Su , Yong-Guang Yang , Liguang Sun
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引用次数: 0

摘要

进入胸腺的造血前体(HPC)会经历一个顺序过程,最终生成各种 T 细胞亚群。这一发育奥德赛在胸腺皮质和髓质内的不同阶段展开,形成了T细胞受体(TCR)表达的格局,并引导胸腺细胞通过阳性和阴性选择。最初,早期胸腺祖细胞(ETPs)居住在胸腺皮质,胸腺细胞在这里开始表达其TCR并接受正向选择。随后,胸腺细胞过渡到胸腺髓质,在那里接受负选择。根据 CD4 和 CD8 核心受体的表达,小鼠和人类胸腺细胞的发育可大致分为不同的阶段,从而分为双阴性(DN)、双阳性(DP)或单阳性(SP)细胞。胸腺细胞在正确的分化阶段迁移到适当的胸腺微环境中,对 T 细胞的发育和正常功能至关重要,而 T 细胞的正常功能对适应性免疫反应至关重要。淋巴祖细胞进入T细胞发育途径的过程取决于分化细胞与胸腺龛发出的信号之间的持续对话。在此,我们回顾了上述关键因素对胸腺细胞定位、迁移和移出的贡献。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Thymocyte migration and emigration

Hematopoietic precursors (HPCs) entering into the thymus undergo a sequential process leading to the generation of a variety of T cell subsets. This developmental odyssey unfolds in distinct stages within the thymic cortex and medulla, shaping the landscape of T cell receptor (TCR) expression and guiding thymocytes through positive and negative selection. Initially, early thymic progenitors (ETPs) take residence in the thymic cortex, where thymocytes begin to express their TCR and undergo positive selection. Subsequently, thymocytes transition to the thymic medulla, where they undergo negative selection. Both murine and human thymocyte development can be broadly classified into distinct stages based on the expression of CD4 and CD8 coreceptors, resulting in categorizations as double negative (DN), double positive (DP) or single positive (SP) cells. Thymocyte migration to the appropriate thymic microenvironment at the right differentiation stage is pivotal for the development and the proper functioning of T cells, which is critical for adaptive immune responses. The journey of lymphoid progenitor cells into the T cell developmental pathway hinges on an ongoing dialogue between the differentiating cell and the signals emanating from the thymus niche. Herein, we review the contribution of the key factors mentioned above for the localization, migration and emigration of thymocytes.

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来源期刊
Immunology letters
Immunology letters 医学-免疫学
CiteScore
7.60
自引率
0.00%
发文量
86
审稿时长
44 days
期刊介绍: Immunology Letters provides a vehicle for the speedy publication of experimental papers, (mini)Reviews and Letters to the Editor addressing all aspects of molecular and cellular immunology. The essential criteria for publication will be clarity, experimental soundness and novelty. Results contradictory to current accepted thinking or ideas divergent from actual dogmas will be considered for publication provided that they are based on solid experimental findings. Preference will be given to papers of immediate importance to other investigators, either by their experimental data, new ideas or new methodology. Scientific correspondence to the Editor-in-Chief related to the published papers may also be accepted provided that they are short and scientifically relevant to the papers mentioned, in order to provide a continuing forum for discussion.
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