空气污染和气象条件对 DED 的影响：相关表现和内在机制。

IF 0.8 4区医学 Q4 OPHTHALMOLOGY

Klinische Monatsblatter fur Augenheilkunde Pub Date : 2024-09-01 Epub Date: 2024-04-30 DOI:10.1055/a-2316-6808

Hui-Zhong Zhou, Xiufen Liu, Dandan Zhou, Fei Shao, Qian Li, Dan Li, Tianlong He, Yu Ren, Cheng-Wei Lu

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引用次数: 0

摘要

本研究旨在探讨干眼症（DED）、空气污染和气象条件之间的关联及其内在机制。干眼症与空气污染物（即 PM2.5、PM10、O3、NO2、CO 和 SO2）和气象条件（即高海拔和风速）呈正相关，而与相对湿度呈负相关。低温和高温都会影响 DED。大气污染物主要通过坏死或自噬、炎症反应和氧化应激影响 DED。气象因素对 DED 的影响不仅在于其自身的影响，还在于其分散了空气污染物的浓度，进而减少了负面暴露。总之，本综述可扩展人们对空气污染和气象因素对 DED 影响的认识，并强调空气环境保护的重要性。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Effects of Air Pollution and Meteorological Conditions on DED: Associated Manifestations and Underlying Mechanisms.

This study aims to explore the associations and the underlying mechanism among dry eye disease (DED), air pollution, and meteorological conditions. DED is positively correlated with air pollutants (i.e., PM_2.5, PM₁₀, O₃, NO₂, CO, and SO₂) and meteorological conditions (i.e., high altitude and wind speed), while negatively associated with relative humidity. Both low and high air temperatures effect DED. Atmospheric pollutants affect DED mainly through necroptosis or autophagy, inflammatory responses, and oxidative stress. Meteorological factors affect DED not only by their own affects but also by dispersing the concentration of air pollutants, and then reducing the negative exposure. In summary, this review may expand the understanding of the effects of air pollution and meteorological factors on DED and emphasize the importance of air environmental protection.

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来源期刊

Klinische Monatsblatter fur Augenheilkunde 医学-眼科学

CiteScore

1.30

自引率

0.00%

发文量

235

审稿时长

4-8 weeks

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