双螺旋核酸中的碱基填充

IF 2.5 4区 化学 Q2 CHEMISTRY, MULTIDISCIPLINARY
Mark Nana Kwame Afari, Tuomas Lönnberg
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引用次数: 0

摘要

碱基填充,即在合成后为寡核苷酸支架添加碱基分子或其类似物,是一种有趣的替代方法,可用于替代(修饰或其他)构建模块顺序耦合的传统方法。碱基分子的可逆连接尤其具有吸引力,因为它允许使用动态组合化学,而且通常会带来更高的保真度。这篇概念文章总结了过去十五年中用于碱基填充的各种骨架和偶联反应,讨论了碱基堆叠和配对对效率和保真度的影响,并重点介绍了潜在的和已实现的应用。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

Base-Filling in Double-Helical Nucleic Acids

Base-Filling in Double-Helical Nucleic Acids

Base-Filling in Double-Helical Nucleic Acids

Base-filling, i. e., post-synthetic furnishing of an oligonucleotide scaffold with base moieties or their analogues, is an interesting alternative to the conventional approach of sequential coupling of building blocks (modified or otherwise). Reversible attachment of the base moieties is particularly attractive as it allows the use of dynamic combinatorial chemistry and usually leads to higher fidelity. This concept article summarizes the various backbones and coupling reactions used for base-filling over the past fifteen years, discusses the impact of base stacking and pairing on efficiency and fidelity and highlights potential and realized applications.

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来源期刊
ChemistryOpen
ChemistryOpen CHEMISTRY, MULTIDISCIPLINARY-
CiteScore
4.80
自引率
4.30%
发文量
143
审稿时长
1 months
期刊介绍: ChemistryOpen is a multidisciplinary, gold-road open-access, international forum for the publication of outstanding Reviews, Full Papers, and Communications from all areas of chemistry and related fields. It is co-owned by 16 continental European Chemical Societies, who have banded together in the alliance called ChemPubSoc Europe for the purpose of publishing high-quality journals in the field of chemistry and its border disciplines. As some of the governments of the countries represented in ChemPubSoc Europe have strongly recommended that the research conducted with their funding is freely accessible for all readers (Open Access), ChemPubSoc Europe was concerned that no journal for which the ethical standards were monitored by a chemical society was available for such papers. ChemistryOpen fills this gap.
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