三层核壳纤维敷料具有持久的血小板保护和持续的生长因子释放能力,可用于慢性伤口愈合。

IF 5.6 1区 医学 Q1 MATERIALS SCIENCE, BIOMATERIALS
Regenerative Biomaterials Pub Date : 2024-03-23 eCollection Date: 2024-01-01 DOI:10.1093/rb/rbae034
Simin Lai, Tingbin Wu, Chenxi Shi, Xiaojing Wang, Pengbi Liu, Lihuan Wang, Hui Yu
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引用次数: 0

摘要

富血小板血浆(PRP)是再生医学中最受欢迎的生物材料之一。然而,其保存过程中遇到的困难以及按需制备的要求严重限制了它的应用。此外,其在伤口微环境中的快速降解使得生长因子无法持续释放,最终降低了对慢性伤口的治疗效果。在此,我们采用一步同轴生物打印技术并结合冷冻干燥技术,开发了一种基于三层核壳纤维的多功能敷料,用于装载和持久保存血小板。血小板被有效地分散并固定在纤维的芯层中,从而实现了 PRP 生长因子的持续释放。释放速度可通过调整三层核壳结构来控制。同时,三层核壳结构还能减少 PRP 在冷冻和储存过程中的失活。实验结果表明,PRP 具有持续活性,即使在储存 180 天后仍能促进伤口愈合。此外,还研究了三层核壳纤维对 PRP 的保护机制,并优化了冻干和储存条件,进一步提高了 PRP 的长期储存性。因此,本研究开发的多功能核壳纤维敷料为持续释放生长因子和持久保存活性 PRP 提供了一种新方法。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Triple-layered core-shell fiber dressings with enduring platelet conservation and sustained growth factor release abilities for chronic wound healing.

Platelet-rich plasma (PRP) is one of the most popular biomaterials in regenerative medicine. However, the difficulties encountered in its preservation, and the requirement for on-demand preparation severely limit its application. In addition, its rapid degradation in the wound microenvironment makes the sustained release of growth factors impossible and finally reduces the therapeutic effect on chronic wounds. Here, a multifunctional dressing based on triple-layered core-shell fibers for loading and enduring preservation of PRP was developed using a one-step coaxial bioprinting technique combined with freeze-drying. The platelets were effectively dispersed and immobilized in the core layer of the fiber, leading to a sustained release of growth factors from the PRP. The rate of release can be controlled by adjusting the triple-layered core-shell structure. Simultaneously, the triple-layered core-shell structure can reduce the deactivation of PRP during freezing and storage. The experimental findings suggest that PRP exhibits sustained activity, facilitating the process of wound healing even after a storage period of 180 days. Furthermore, the protective mechanism of PRP by the triple-layered core-shell fiber was investigated, and the conditions for freeze-drying and storage were optimized, further enhancing the long-term storability of PRP. As a result, the multifunctional core-shell fiber dressings developed in this study offer a novel approach for sustained growth factor release and the enduring preservation of active PRP.

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来源期刊
Regenerative Biomaterials
Regenerative Biomaterials Materials Science-Biomaterials
CiteScore
7.90
自引率
16.40%
发文量
92
审稿时长
10 weeks
期刊介绍: Regenerative Biomaterials is an international, interdisciplinary, peer-reviewed journal publishing the latest advances in biomaterials and regenerative medicine. The journal provides a forum for the publication of original research papers, reviews, clinical case reports, and commentaries on the topics relevant to the development of advanced regenerative biomaterials concerning novel regenerative technologies and therapeutic approaches for the regeneration and repair of damaged tissues and organs. The interactions of biomaterials with cells and tissue, especially with stem cells, will be of particular focus.
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