Nidia Castro dos Santos, Miriam R. Westphal, Belen Retamal-Valdes, Poliana Mendes Duarte, Luciene Cristina Figueiredo, Marcelo Faveri, Jamil Shibli, Geisla Soares, Tamires Miranda, Daiane Fermiano, Ivan Borges, Cristiane Goncalves, Caio Junji Tanaka, Flavia Teles, Max Goodson, Hatice Hasturk, Thomas Van Dyke, Benjamin Ehmke, Peter Eickholz, Katrin Nickles, Ulrich Schlagenhauf, Joerg Meyle, Thomas Kocher, Ti-Sun Kim, Helio Doyle, Magda Feres
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Westphal, Belen Retamal-Valdes, Poliana Mendes Duarte, Luciene Cristina Figueiredo, Marcelo Faveri, Jamil Shibli, Geisla Soares, Tamires Miranda, Daiane Fermiano, Ivan Borges, Cristiane Goncalves, Caio Junji Tanaka, Flavia Teles, Max Goodson, Hatice Hasturk, Thomas Van Dyke, Benjamin Ehmke, Peter Eickholz, Katrin Nickles, Ulrich Schlagenhauf, Joerg Meyle, Thomas Kocher, Ti-Sun Kim, Helio Doyle, Magda Feres","doi":"10.1111/jre.13272","DOIUrl":null,"url":null,"abstract":"<div>\n \n \n <section>\n \n <h3> Aims</h3>\n \n <p>To explore the influence of gender on periodontal treatment outcomes in a dataset of eight RCTs conducted in Brazil, United States, and Germany.</p>\n </section>\n \n <section>\n \n <h3> Methods</h3>\n \n <p>Clinical parameters were compared between men and women with stages III/IV grades B/C generalized periodontitis at baseline and 1-year post-therapy, including scaling and root planing with or without antibiotics.</p>\n </section>\n \n <section>\n \n <h3> Results</h3>\n \n <p>Data from 1042 patients were analyzed. Men presented a tendency towards higher probing depth (<i>p</i> = .07, effect size = 0.11) and clinical attachment level (CAL) than women at baseline (<i>p</i> = .01, effect size = 0.16). Males also presented statistically significantly lower CAL gain at sites with CAL of 4–6 mm at 1-year post-therapy (<i>p</i> = .001, effect size = 0.20). Among patients with Grade B periodontitis who took antibiotics, a higher frequency of women achieved the endpoint for treatment (i.e., ≤4 sites PD ≥5 mm) at 1 year than men (<i>p</i> < .05, effect size = 0.12).</p>\n </section>\n \n <section>\n \n <h3> Conclusion</h3>\n \n <p>Men enrolled in RCTs showed a slightly inferior clinical response to periodontal therapy in a limited number of sub-analyses when compared to women. These small differences did not appear to be clinically relevant. 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引用次数: 0
摘要
目的:在巴西、美国和德国进行的八项研究性临床试验的数据集中,探讨性别对牙周治疗结果的影响:方法:比较患有 III/IV 期 B/C 级全身性牙周炎的男性和女性在基线和治疗后 1 年的临床参数,包括使用或不使用抗生素进行洗牙和根面平整:对 1042 名患者的数据进行了分析。基线时,男性探诊深度(p = .07,效应大小 = 0.11)和临床附着水平(CAL)均高于女性(p = .01,效应大小 = 0.16)。在治疗后 1 年,CAL 为 4-6 mm 的部位,男性的 CAL 增量也明显低于女性(p = .001,效应大小 = 0.20)。在服用抗生素的 B 级牙周炎患者中,1 年后达到治疗终点(即≤4 个部位 PD ≥5 mm)的女性多于男性(p 结论:治疗后 1 年的 CAL 增量明显低于治疗前 1 年的 CAL 增量(p = 0.001):在有限的几项子分析中,参与研究性试验的男性对牙周治疗的临床反应略逊于女性。这些微小的差异似乎与临床无关。虽然性别并不决定该人群对牙周治疗的临床反应,但我们的研究结果表明,未来的研究应继续探讨这一主题。
Influence of gender on periodontal outcomes: A retrospective analysis of eight randomized clinical trials
Aims
To explore the influence of gender on periodontal treatment outcomes in a dataset of eight RCTs conducted in Brazil, United States, and Germany.
Methods
Clinical parameters were compared between men and women with stages III/IV grades B/C generalized periodontitis at baseline and 1-year post-therapy, including scaling and root planing with or without antibiotics.
Results
Data from 1042 patients were analyzed. Men presented a tendency towards higher probing depth (p = .07, effect size = 0.11) and clinical attachment level (CAL) than women at baseline (p = .01, effect size = 0.16). Males also presented statistically significantly lower CAL gain at sites with CAL of 4–6 mm at 1-year post-therapy (p = .001, effect size = 0.20). Among patients with Grade B periodontitis who took antibiotics, a higher frequency of women achieved the endpoint for treatment (i.e., ≤4 sites PD ≥5 mm) at 1 year than men (p < .05, effect size = 0.12).
Conclusion
Men enrolled in RCTs showed a slightly inferior clinical response to periodontal therapy in a limited number of sub-analyses when compared to women. These small differences did not appear to be clinically relevant. Although gender did not dictate the clinical response to periodontal treatment in this population, our findings suggest that future research should continue to explore this topic.
期刊介绍:
The Journal of Periodontal Research is an international research periodical the purpose of which is to publish original clinical and basic investigations and review articles concerned with every aspect of periodontology and related sciences. Brief communications (1-3 journal pages) are also accepted and a special effort is made to ensure their rapid publication. Reports of scientific meetings in periodontology and related fields are also published.
One volume of six issues is published annually.