吸入电子烟对电子烟使用者黏膜纤毛清除率的急性影响

IF 2 4区 医学 Q3 RESPIRATORY SYSTEM
William D Bennett, Phillip W Clapp, Kirby L Zeman, Jihong Wu, Brian Ring, Ilona Jaspers
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引用次数: 0

摘要

背景:最近的研究表明,电子烟(EC)使用者的慢性支气管炎症状发生率增加,这可能与粘膜纤毛清除率(MCC)降低有关。关于吸入电子烟对体内 MCC 的急性或慢性影响,目前所知甚少。方法:在控制吸入放射性标记(Tc99m 硫胶体)气溶胶后,测量年轻成年吸食者(n = 5 名男性,平均年龄 = 21 岁)的体内 MCC。放射性标记沉积微粒的全肺清除率是在 90 分钟内测量的基线 MCC,以及在测量 MCC 的前 60 分钟内与受控定期吸食相关的情况。吸食挑战是通过含有无味电子液体(65%丙二醇/35%植物甘油,3毫克/毫升游离基尼古丁)的第四代盒式电子烟进行的。该挑战在每隔 10 分钟测量一次 MCC 时开始进行,每 30 秒吸一口,持续 5 分钟(即在最初 60 分钟的 MCC 测量期间,每隔 10 分钟吸 10 口,共吸 60 口)。结果:与基线相比,在 90 分钟的 MCC 测量过程中,外周肺平均清除率(%)有所提高,这与欧共体挑战有关,分别为 12(±6)与 24(±6)(p 结论:欧共体挑战对外周肺平均清除率的影响很小:在挑战欧共体期间,体内 MCC 的急性增强与最近的研究相反,这些研究显示,在尼古丁水平高于本文所用水平的情况下,尼古丁会导致纤毛跳动和粘液运输减慢。不过,我们的研究结果与支气管气道表面液体量和粘蛋白分泌量的急性增加是一致的,但这种增加可能是短暂的。本刊物所报道的研究得到了美国国立卫生研究院 R01HL139369 的支持,并在 ClinicalTrials.gov (NCT03700892) 上进行了注册。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Acute Effect of E-Cigarette Inhalation on Mucociliary Clearance in E-Cigarette Users.

Background: Recent studies show e-cigarette (EC) users have increased rates of chronic bronchitic symptoms that may be associated with depressed mucociliary clearance (MCC). Little is known about the acute or chronic effects of EC inhalation on in vivo MCC. Methods: In vivo MCC was measured in young adult vapers (n = 5 males, mean age = 21) after controlled inhalation of a radiolabeled (Tc99m sulfur colloid) aerosol. Whole-lung clearance of radiolabeled deposited particles was measured over a 90-minute period for baseline MCC and associated with controlled periodic vaping over the first 60 minutes of MCC measurements. The vaping challenge was administered from a fourth generation box mod EC containing unflavored e-liquid (65% propylene glycol/35% vegetable glycerin, 3 mg/mL freebase nicotine). The challenge was administered at the start of each 10-minute interval of MCC measurements and consisted of 1 puff every 30 seconds for 5 minutes (i.e., 10 puffs for each 10-minute period for a total of 60 puffs during the initial 60 minutes of MCC measurements). Results: Compared with baseline, peripheral lung average clearance (%) over the 90 minutes of MCC measures was enhanced, associated with EC challenge, 12 (±6) versus 24 (±6), respectively (p < 0.05 by Wilcoxon signed-rank test). Conclusions: Acute enhancement of in vivo MCC during EC challenge is contrary to recent studies showing nicotine-associated slowing of ciliary beat and mucus transport at higher nicotine levels than those used here. However, our findings are consistent with an acute increase in fluid volume and mucin secretion to the bronchial airway surface that is likely short lived. Research reported in this publication was supported by the National Institutes of Health R01HL139369 and registered with ClinicalTrials.gov (NCT03700892).

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来源期刊
CiteScore
6.70
自引率
2.90%
发文量
34
审稿时长
>12 weeks
期刊介绍: Journal of Aerosol Medicine and Pulmonary Drug Delivery is the only peer-reviewed journal delivering innovative, authoritative coverage of the health effects of inhaled aerosols and delivery of drugs through the pulmonary system. The Journal is a forum for leading experts, addressing novel topics such as aerosolized chemotherapy, aerosolized vaccines, methods to determine toxicities, and delivery of aerosolized drugs in the intubated patient. Journal of Aerosol Medicine and Pulmonary Drug Delivery coverage includes: Pulmonary drug delivery Airway reactivity and asthma treatment Inhalation of particles and gases in the respiratory tract Toxic effects of inhaled agents Aerosols as tools for studying basic physiologic phenomena.
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