异种移植右心室至肺动脉导管的新型模型

IF 3.1 3区 医学 Q2 ENGINEERING, BIOMEDICAL
ASAIO Journal Pub Date : 2024-10-01 Epub Date: 2024-04-26 DOI:10.1097/MAT.0000000000002213
Chace B Mitchell, Luke M Wiggins, Winfield J Wells, David C Cleveland, John D Cleveland
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引用次数: 0

摘要

在过去的 40 年里,新生儿心脏外科手术治疗各种先天性心脏病的效果有了显著改善。随着越来越多的患者存活到成年,这些患者的初始治疗策略的长期影响已成为人们关注的焦点。这对小儿心脏瓣膜病患者来说尤其如此。许多先天性右心室至肺动脉(RVPA)不连续的患者需要在新生儿期植入瓣膜导管。由于患者体型较大,无法适应体格生长,因此在这类患者中,瓣膜导管的选择非常有限。基因工程猪(GEP)供体可提供一种异种导管替代方案,它能与患者一起生长。我们开发了一种利用 GEP 供体 RVPA 导管的模型,将其置于幼年非人灵长类动物 (NHP) 受体中。我们的受体一直使用单药免疫抑制,在短期随访中未发现肺动脉瓣功能不全或狭窄的迹象。要确定这项技术在人类应用中的效用,还需要进一步的研究和长期结果。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
A Novel Model for Xenograft Right Ventricle to Pulmonary Artery Conduit.

The last 40 years have shown dramatic improvement in outcomes for neonatal cardiac surgery for a spectrum of congenital heart disease diagnoses. With more patients surviving into adulthood, the long-term impact of initial management strategies of these patients has come into focus. This is particularly true for patients with pediatric heart valve disease. Many patients born with right ventricular to pulmonary artery (RVPA) discontinuity require placement of a valved conduit in the neonatal period. Valved conduit options are limited in this patient population due to patient size and inability to respond to somatic growth. Genetically engineered porcine (GEP) donors may offer a xenograft conduit alternative that can grow with the patient. We have developed a model utilizing GEP donor RVPA conduits placed in infantile nonhuman primate (NHP) recipients. Our recipient is maintained on single-drug immunosuppression and demonstrates no evidence of pulmonary valve insufficiency or stenosis during short-term follow-up. Further studies and long-term outcomes are necessary to determine the utility of this technology in human application.

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来源期刊
ASAIO Journal
ASAIO Journal 医学-工程:生物医学
CiteScore
6.60
自引率
7.10%
发文量
651
审稿时长
4-8 weeks
期刊介绍: ASAIO Journal is in the forefront of artificial organ research and development. On the cutting edge of innovative technology, it features peer-reviewed articles of the highest quality that describe research, development, the most recent advances in the design of artificial organ devices and findings from initial testing. Bimonthly, the ASAIO Journal features state-of-the-art investigations, laboratory and clinical trials, and discussions and opinions from experts around the world. The official publication of the American Society for Artificial Internal Organs.
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