自闭症谱系障碍中的益生菌:动物模型的最新见解。

IF 5.2 2区 心理学 Q1 PSYCHOLOGY, DEVELOPMENTAL
Autism Pub Date : 2024-11-01 Epub Date: 2024-04-26 DOI:10.1177/13623613241246911
Navid Golbaghi, Saeideh Naeimi, Afra Darvishi, Niloofar Najari, Sofia Cussotto
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引用次数: 0

摘要

内容提要:自闭症谱系障碍是一种神经发育障碍,其特征是广泛的行为改变,包括社会交往障碍和重复行为。针对自闭症谱系障碍开发了许多药物干预措施,但往往效果不佳,并伴有多种副作用。肠道微生物群是栖息在我们胃肠道中的细菌库。在自闭症谱系障碍患者身上观察到的肠道微生物改变,包括类杆菌、固缩菌和变形菌水平的升高以及双歧杆菌水平的降低,为进一步研究肠道微生物群在自闭症谱系障碍中的作用提供了依据。最近的临床前研究表明,益生菌疗法具有良好的效果,包括改善氧化应激、抗炎作用、调节神经递质和恢复微生物平衡。本综述旨在通过对近期动物研究的深入了解,探讨益生菌在自闭症谱系障碍的管理和治疗方面的潜力。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Probiotics in autism spectrum disorder: Recent insights from animal models.

Lay abstract: Autism spectrum disorder is a neurodevelopmental disorder characterized by a wide range of behavioral alterations, including impaired social interaction and repetitive behaviors. Numerous pharmacological interventions have been developed for autism spectrum disorder, often proving ineffective and accompanied by a multitude of side effects. The gut microbiota is the reservoir of bacteria inhabiting our gastrointestinal tract. The gut microbial alterations observed in individuals with autism spectrum disorder, including elevated levels of Bacteroidetes, Firmicutes, and Proteobacteria, as well as reduced levels of Bifidobacterium, provide a basis for further investigation into the role of the gut microbiota in autism spectrum disorder. Recent preclinical studies have shown favorable outcomes with probiotic therapy, including improvements in oxidative stress, anti-inflammatory effects, regulation of neurotransmitters, and restoration of microbial balance. The aim of this review is to explore the potential of probiotics for the management and treatment of autism spectrum disorder, by investigating insights from recent studies in animals.

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来源期刊
Autism
Autism PSYCHOLOGY, DEVELOPMENTAL-
CiteScore
9.80
自引率
11.50%
发文量
160
期刊介绍: Autism is a major, peer-reviewed, international journal, published 8 times a year, publishing research of direct and practical relevance to help improve the quality of life for individuals with autism or autism-related disorders. It is interdisciplinary in nature, focusing on research in many areas, including: intervention; diagnosis; training; education; translational issues related to neuroscience, medical and genetic issues of practical import; psychological processes; evaluation of particular therapies; quality of life; family needs; and epidemiological research. Autism provides a major international forum for peer-reviewed research of direct and practical relevance to improving the quality of life for individuals with autism or autism-related disorders. The journal''s success and popularity reflect the recent worldwide growth in the research and understanding of autistic spectrum disorders, and the consequent impact on the provision of treatment and care. Autism is interdisciplinary in nature, focusing on evaluative research in all areas, including: intervention, diagnosis, training, education, neuroscience, psychological processes, evaluation of particular therapies, quality of life issues, family issues and family services, medical and genetic issues, epidemiological research.
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