空气污染物对兰州小儿特应性皮炎门诊量的影响

Q4 Medicine

中国医学科学院学报 Pub Date : 2024-06-01 DOI:10.3881/j.issn.1000-503X.15902

Can Li, Fei Wang, Yuan He, Chun-Rui Shi

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concentration,the excess risk (ER) for pediatric atopic dermatitis outpatient visits was 0.05% (95%CI=0-0.10%,P=0.049);and O3 exhibited the most significant effect on day 7 of the cumulative lag (Lag07),with a statistically significant increase in the ER for each 10 μg/m3 increase in its concentration of 7.40% (95%CI=5.31%-9.53%,P<0.001) for pediatric atopic dermatitis outpatient visits.Age stratification showed that children aged 0-3 years with atopic dermatitis were the most sensitive to CO,with an increased ER of 0.09% (95%CI=0.04%-0.15%,P<0.001) for every 10 μg/m3 increase in concentration,and children aged 7-14 years with atopic dermatitis were the most sensitive to O3,with an increased ER of 8.26% (95%CI=4.99%-11.64%,P<0.001) for every 10 μg/m3 increase in concentration.Seasonal stratification showed that CO exerted a stronger effect on pediatric atopic dermatitis outpatient visits in summer and fall,with ER values of 0.45% and 0.16% (both P<0.001),respectively,while O3 had a 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引用次数: 0

摘要

目的分析兰州市空气污染物与小儿特应性皮炎门诊量的相关性，为相关部门对患儿的生活指导和疾病预防提供科学依据。方法采用广义相加模型分析兰州市空气污染物对小儿特应性皮炎门诊量的影响和滞后效应，同时控制长期趋势、节假日效应、星期效应和气象因素等混杂因素。结果 NO2、PM2.5、PM10和SO2对小儿特应性皮炎门诊量的影响在当日（Lag0）最为显著，但无统计学意义（均P>0.05）；CO对Lag0的影响也最为显著，其浓度每增加10 μg/m3，小儿特应性皮炎门诊量的超额风险（ER）为0.05%（95%CI=0-0.10%，P=0.049）；O3 在累积滞后第 7 天（Lag07）表现出最显著的影响，其浓度每增加 10 μg/m3 ，小儿特应性皮炎门诊的超额风险（ER）就会增加 7.40% （95%CI=5.31%-9.季节分层显示，夏季和秋季 CO 对小儿特应性皮炎门诊量的影响更大，ER 值分别为 0.45% 和 0.16% （95%CI=4.99%-11.64%，P3）。季节分层显示，CO对夏季和秋季小儿特应性皮炎门诊量的影响更大，ER值分别为0.45%和0.16%（P3对冬季门诊量的影响均显著，ER值为20.48%）。

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[Impact of Air Pollutants on Outpatient Visits for Pediatric Atopic Dermatitis in Lanzhou].

Objective To analyze the correlation between air pollutants and pediatric atopic dermatitis outpatient visits in Lanzhou,and provide scientific insights for the life guidance of the affected children and disease prevention by relevant departments.Methods A generalized additive model was employed to analyze the effects and lagged effects of air pollutants on pediatric atopic dermatitis outpatient visits in Lanzhou while controlling for confounding factors such as long-term trends,holiday effects,day of the week effects and meteorological factors.Results The effects of NO₂,PM_2.5,PM₁₀,and SO₂ on pediatric atopic dermatitis outpatient visits were most significant on the current day(Lag0),but were not statistically significant (all P>0.05);CO also had the most significant effect on Lag0,and for every 10 μg/m³ increase in its concentration,the excess risk (ER) for pediatric atopic dermatitis outpatient visits was 0.05% (95%CI=0-0.10%,P=0.049);and O₃ exhibited the most significant effect on day 7 of the cumulative lag (Lag07),with a statistically significant increase in the ER for each 10 μg/m³ increase in its concentration of 7.40% (95%CI=5.31%-9.53%,P<0.001) for pediatric atopic dermatitis outpatient visits.Age stratification showed that children aged 0-3 years with atopic dermatitis were the most sensitive to CO,with an increased ER of 0.09% (95%CI=0.04%-0.15%,P<0.001) for every 10 μg/m³ increase in concentration,and children aged 7-14 years with atopic dermatitis were the most sensitive to O₃,with an increased ER of 8.26% (95%CI=4.99%-11.64%,P<0.001) for every 10 μg/m³ increase in concentration.Seasonal stratification showed that CO exerted a stronger effect on pediatric atopic dermatitis outpatient visits in summer and fall,with ER values of 0.45% and 0.16% (both P<0.001),respectively,while O₃ had a significant effect on outpatient visits in winter,with an ER value of 20.48% (P<0.001).Conclusion Elevated daily average concentrations of air pollutants CO and O₃ in Lanzhou were positively correlated with the number of outpatient visits for atopic dermatitis in children,with significant seasonal effects and age-stratified sensitivities.

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来源期刊

中国医学科学院学报 Medicine-Medicine (all)

CiteScore

0.60

自引率

0.00%

发文量

6813

期刊介绍： Acta Academiae Medicinae Sinicae was founded in February 1979. It is a comprehensive medical academic journal published in China and abroad, supervised by the Ministry of Health of the People's Republic of China and sponsored by the Chinese Academy of Medical Sciences and Peking Union Medical College. The journal mainly reports the latest research results, work progress and dynamics in the fields of basic medicine, clinical medicine, pharmacy, preventive medicine, biomedicine, medical teaching and research, aiming to promote the exchange of medical information and improve the academic level of medicine. At present, the journal has been included in 10 famous foreign retrieval systems and their databases [Medline (PubMed online version), Elsevier, EMBASE, CA, WPRIM, ExtraMED, IC, JST, UPD and EBSCO-ASP]; and has been included in important domestic retrieval systems and databases [China Science Citation Database (Documentation and Information Center of the Chinese Academy of Sciences), China Core Journals Overview (Peking University Library), China Science and Technology Paper Statistical Source Database (China Science and Technology Core Journals) (China Institute of Scientific and Technological Information), China Science and Technology Journal Paper and Citation Database (China Institute of Scientific and Technological Information)].