追踪胚胎造血过程，引导多能干细胞诱导为造血祖细胞

IF 10.7 1区生物学 Q1 CELL BIOLOGY

Developmental cell Pub Date : 2024-05-06 DOI:10.1016/j.devcel.2024.04.001

Xinjian Mao, Linheng Li

引用次数: 0

摘要

在本期《发育细胞》（Developmental Cell）杂志上，Fowler等人应用遗传系谱追踪小鼠模型，支持动脉内皮细胞是造血干细胞主要来源的观点。他们利用这一点，开发出了一种能将人类多能干细胞有效分化成HLF+HOXA+造血祖细胞的方法。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Tracing embryonic hematopoiesis guides induction of pluripotent stem cells to hematopoietic progenitors

In this issue of Developmental Cell, Fowler et al. applied genetic lineage-tracing mouse models to support the notion that artery endothelial cells are the predominant source of hematopoietic stem cells. They leveraged this and developed a method capable of efficiently differentiating human pluripotent stem cells into HLF⁺HOXA⁺ hematopoietic progenitors.

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来源期刊

Developmental cell 生物-发育生物学

CiteScore

18.90

自引率

1.70%

发文量

203

审稿时长

3-6 weeks

期刊介绍： Developmental Cell, established in 2001, is a comprehensive journal that explores a wide range of topics in cell and developmental biology. Our publication encompasses work across various disciplines within biology, with a particular emphasis on investigating the intersections between cell biology, developmental biology, and other related fields. Our primary objective is to present research conducted through a cell biological perspective, addressing the essential mechanisms governing cell function, cellular interactions, and responses to the environment. Moreover, we focus on understanding the collective behavior of cells, culminating in the formation of tissues, organs, and whole organisms, while also investigating the consequences of any malfunctions in these intricate processes.