Salma Younes, Eleonora Nicolai, Massimo Pieri, Sergio Bernardini, Hanin I. Daas, Duaa W. Al-Sadeq, Nadin Younes, Farah M. Shurrab, Parveen B. Nizamuddin, Fathima Humaira, Nader Al-Dewik, Hadi M. Yassine, Laith J. Abu-Raddad, Ahmed Ismail, Gheyath K. Nasrallah
{"title":"BNT162b2 或 mRNA-1273 异源加强免疫后 SARS-CoV-2 IgA、IgG、中和及总抗体反应的随访和比较评估","authors":"Salma Younes, Eleonora Nicolai, Massimo Pieri, Sergio Bernardini, Hanin I. Daas, Duaa W. Al-Sadeq, Nadin Younes, Farah M. Shurrab, Parveen B. Nizamuddin, Fathima Humaira, Nader Al-Dewik, Hadi M. Yassine, Laith J. Abu-Raddad, Ahmed Ismail, Gheyath K. Nasrallah","doi":"10.1111/irv.13290","DOIUrl":null,"url":null,"abstract":"<div>\n \n \n <section>\n \n <h3> Background</h3>\n \n <p>Priming with ChAdOx1 followed by heterologous boosting is considered in several countries. Nevertheless, analyses comparing the immunogenicity of heterologous booster to homologous primary vaccination regimens and natural infection are lacking. In this study, we aimed to conduct a comparative assessment of the immunogenicity between homologous primary vaccination regimens and heterologous prime-boost vaccination using BNT162b2 or mRNA-1273.</p>\n </section>\n \n <section>\n \n <h3> Methods</h3>\n \n <p>We matched vaccinated naïve (VN) individuals (<i>n</i> = 673) with partial vaccination (<i>n</i> = 64), primary vaccination (<i>n</i> = 590), and primary series plus mRNA vaccine heterologous booster (<i>n</i> = 19) with unvaccinated naturally infected (NI) individuals with a documented primary SARS-CoV-2 infection (<i>n</i> = 206). We measured the levels of neutralizing total antibodies (NTAbs), total antibodies (TAbs), anti-S-RBD IgG, and anti-S1 IgA titers.</p>\n </section>\n \n <section>\n \n <h3> Results</h3>\n \n <p>Homologous primary vaccination with ChAdOx1 not only showed less potent NTAb, TAb, anti-S-RBD IgG, and anti-S1 IgA immune responses compared to primary BNT162b2 or mRNA-1273 vaccination regimens (<i>p</i> < 0.05) but also showed ~3-fold less anti-S1 IgA response compared to infection-induced immunity (<i>p</i> < 0.001). Nevertheless, a heterologous booster led to an increase of ~12 times in the immune response when compared to two consecutive homologous ChAdOx1 immunizations. Furthermore, correlation analyses revealed that both anti-S-RBD IgG and anti-S1 IgA significantly contributed to virus neutralization among NI individuals, particularly in symptomatic and pauci-symptomatic individuals, whereas among VN individuals, anti-S-RBD IgG was the main contributor to virus neutralization.</p>\n </section>\n \n <section>\n \n <h3> Conclusion</h3>\n \n <p>The results emphasize the potential benefit of using heterologous mRNA boosters to increase antibody levels and neutralizing capacity particularly in patients who received primary vaccination with ChAdOx1.</p>\n </section>\n </div>","PeriodicalId":13544,"journal":{"name":"Influenza and Other Respiratory Viruses","volume":null,"pages":null},"PeriodicalIF":4.3000,"publicationDate":"2024-05-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/irv.13290","citationCount":"0","resultStr":"{\"title\":\"Follow-Up and Comparative Assessment of SARS-CoV-2 IgA, IgG, Neutralizing, and Total Antibody Responses After BNT162b2 or mRNA-1273 Heterologous Booster Vaccination\",\"authors\":\"Salma Younes, Eleonora Nicolai, Massimo Pieri, Sergio Bernardini, Hanin I. Daas, Duaa W. Al-Sadeq, Nadin Younes, Farah M. Shurrab, Parveen B. Nizamuddin, Fathima Humaira, Nader Al-Dewik, Hadi M. Yassine, Laith J. Abu-Raddad, Ahmed Ismail, Gheyath K. Nasrallah\",\"doi\":\"10.1111/irv.13290\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div>\\n \\n \\n <section>\\n \\n <h3> Background</h3>\\n \\n <p>Priming with ChAdOx1 followed by heterologous boosting is considered in several countries. Nevertheless, analyses comparing the immunogenicity of heterologous booster to homologous primary vaccination regimens and natural infection are lacking. In this study, we aimed to conduct a comparative assessment of the immunogenicity between homologous primary vaccination regimens and heterologous prime-boost vaccination using BNT162b2 or mRNA-1273.</p>\\n </section>\\n \\n <section>\\n \\n <h3> Methods</h3>\\n \\n <p>We matched vaccinated naïve (VN) individuals (<i>n</i> = 673) with partial vaccination (<i>n</i> = 64), primary vaccination (<i>n</i> = 590), and primary series plus mRNA vaccine heterologous booster (<i>n</i> = 19) with unvaccinated naturally infected (NI) individuals with a documented primary SARS-CoV-2 infection (<i>n</i> = 206). We measured the levels of neutralizing total antibodies (NTAbs), total antibodies (TAbs), anti-S-RBD IgG, and anti-S1 IgA titers.</p>\\n </section>\\n \\n <section>\\n \\n <h3> Results</h3>\\n \\n <p>Homologous primary vaccination with ChAdOx1 not only showed less potent NTAb, TAb, anti-S-RBD IgG, and anti-S1 IgA immune responses compared to primary BNT162b2 or mRNA-1273 vaccination regimens (<i>p</i> < 0.05) but also showed ~3-fold less anti-S1 IgA response compared to infection-induced immunity (<i>p</i> < 0.001). Nevertheless, a heterologous booster led to an increase of ~12 times in the immune response when compared to two consecutive homologous ChAdOx1 immunizations. 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Follow-Up and Comparative Assessment of SARS-CoV-2 IgA, IgG, Neutralizing, and Total Antibody Responses After BNT162b2 or mRNA-1273 Heterologous Booster Vaccination
Background
Priming with ChAdOx1 followed by heterologous boosting is considered in several countries. Nevertheless, analyses comparing the immunogenicity of heterologous booster to homologous primary vaccination regimens and natural infection are lacking. In this study, we aimed to conduct a comparative assessment of the immunogenicity between homologous primary vaccination regimens and heterologous prime-boost vaccination using BNT162b2 or mRNA-1273.
Methods
We matched vaccinated naïve (VN) individuals (n = 673) with partial vaccination (n = 64), primary vaccination (n = 590), and primary series plus mRNA vaccine heterologous booster (n = 19) with unvaccinated naturally infected (NI) individuals with a documented primary SARS-CoV-2 infection (n = 206). We measured the levels of neutralizing total antibodies (NTAbs), total antibodies (TAbs), anti-S-RBD IgG, and anti-S1 IgA titers.
Results
Homologous primary vaccination with ChAdOx1 not only showed less potent NTAb, TAb, anti-S-RBD IgG, and anti-S1 IgA immune responses compared to primary BNT162b2 or mRNA-1273 vaccination regimens (p < 0.05) but also showed ~3-fold less anti-S1 IgA response compared to infection-induced immunity (p < 0.001). Nevertheless, a heterologous booster led to an increase of ~12 times in the immune response when compared to two consecutive homologous ChAdOx1 immunizations. Furthermore, correlation analyses revealed that both anti-S-RBD IgG and anti-S1 IgA significantly contributed to virus neutralization among NI individuals, particularly in symptomatic and pauci-symptomatic individuals, whereas among VN individuals, anti-S-RBD IgG was the main contributor to virus neutralization.
Conclusion
The results emphasize the potential benefit of using heterologous mRNA boosters to increase antibody levels and neutralizing capacity particularly in patients who received primary vaccination with ChAdOx1.
期刊介绍：
Influenza and Other Respiratory Viruses is the official journal of the International Society of Influenza and Other Respiratory Virus Diseases - an independent scientific professional society - dedicated to promoting the prevention, detection, treatment, and control of influenza and other respiratory virus diseases.
Influenza and Other Respiratory Viruses is an Open Access journal. Copyright on any research article published by Influenza and Other Respiratory Viruses is retained by the author(s). Authors grant Wiley a license to publish the article and identify itself as the original publisher. Authors also grant any third party the right to use the article freely as long as its integrity is maintained and its original authors, citation details and publisher are identified.
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