Ahmed K. Saleh , Ahmed Saber Hussein , Julie Basu Ray , Ahmed S. Elzaref
{"title":"使用石榴皮提取物制备环保型氧化锌和氧化钴纳米颗粒的多功能性比较和多样化生物应用","authors":"Ahmed K. Saleh , Ahmed Saber Hussein , Julie Basu Ray , Ahmed S. Elzaref","doi":"10.1016/j.nanoso.2024.101174","DOIUrl":null,"url":null,"abstract":"<div><p>A fundamental element of nanotechnology today is the advancement of sustainable, environmentally friendly and economically viable approaches to green synthesis of nanomaterials. In this study, fresh aqueous extract of pomegranate peels was used as reducing and stabilizing agents in a rapid and eco-friendly approach for the synthesis of zinc oxide nanoparticles (ZnO-NPs) and cobalt oxide nanoparticles (Co<sub>3</sub>O<sub>4</sub>-NPs). X-ray diffraction (XRD), Scanning Electron Microscopy (SEM), Transmission electron microscope (TEM), Energy Dispersive Analysis of X-rays (EDX), and Fourier-transform Infrared Spectroscopy (FT-IR) were used to analyze the biosynthesized ZnO-NPs and Co<sub>3</sub>O<sub>4</sub>-NPs. XRD analysis confirmed the crystalline structures of ZnO-NPs and Co<sub>3</sub>O<sub>4</sub>-NPs as approximately 33.4 and 11.9 nm, respectively. SEM images showed distinct morphologies, while EDX and elemental mapping confirmed compositional integrity. FT-IR validated the characteristic functional groups present in both nanoparticles. TEM analysis provide the average particle size of ZnO-NPs and Co<sub>3</sub>O<sub>4</sub>-NPs were observed at 41.25 and 17.19 nm, respectively. The zeta potential of green synthesized ZnO-NPs and Co<sub>3</sub>O<sub>4</sub>-NPs were found to have a distinct peak at −12.5 and −16.3 mV, respectively. Both NPs have shown potent antimicrobial activity against four common pathogens, with increased antimicrobial activity against increasing concentrations of NPs. <em>In vivo</em> studies show a protective role for both ZnO-NPs and Co<sub>3</sub>O<sub>4</sub>-NPs against doxorubicin (DOX)-induced toxicity. In addition, Co<sub>3</sub>O<sub>4</sub>-NPs were effective against hepatotoxicity, nephrotoxicity, and endocrine disruption in male albino rats. Multi-technique investigation in this study offers a comprehensive understanding and indicates promising biological applications of ZnO-NPs and Co<sub>3</sub>O<sub>4</sub>-NPs.</p></div>","PeriodicalId":397,"journal":{"name":"Nano-Structures & Nano-Objects","volume":null,"pages":null},"PeriodicalIF":5.4500,"publicationDate":"2024-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Comparative versatility and diverse biological applications of eco-friendly zinc oxide and cobalt oxide nanoparticles using Punica granatum L. peel extract\",\"authors\":\"Ahmed K. Saleh , Ahmed Saber Hussein , Julie Basu Ray , Ahmed S. Elzaref\",\"doi\":\"10.1016/j.nanoso.2024.101174\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><p>A fundamental element of nanotechnology today is the advancement of sustainable, environmentally friendly and economically viable approaches to green synthesis of nanomaterials. In this study, fresh aqueous extract of pomegranate peels was used as reducing and stabilizing agents in a rapid and eco-friendly approach for the synthesis of zinc oxide nanoparticles (ZnO-NPs) and cobalt oxide nanoparticles (Co<sub>3</sub>O<sub>4</sub>-NPs). X-ray diffraction (XRD), Scanning Electron Microscopy (SEM), Transmission electron microscope (TEM), Energy Dispersive Analysis of X-rays (EDX), and Fourier-transform Infrared Spectroscopy (FT-IR) were used to analyze the biosynthesized ZnO-NPs and Co<sub>3</sub>O<sub>4</sub>-NPs. XRD analysis confirmed the crystalline structures of ZnO-NPs and Co<sub>3</sub>O<sub>4</sub>-NPs as approximately 33.4 and 11.9 nm, respectively. SEM images showed distinct morphologies, while EDX and elemental mapping confirmed compositional integrity. FT-IR validated the characteristic functional groups present in both nanoparticles. TEM analysis provide the average particle size of ZnO-NPs and Co<sub>3</sub>O<sub>4</sub>-NPs were observed at 41.25 and 17.19 nm, respectively. The zeta potential of green synthesized ZnO-NPs and Co<sub>3</sub>O<sub>4</sub>-NPs were found to have a distinct peak at −12.5 and −16.3 mV, respectively. Both NPs have shown potent antimicrobial activity against four common pathogens, with increased antimicrobial activity against increasing concentrations of NPs. <em>In vivo</em> studies show a protective role for both ZnO-NPs and Co<sub>3</sub>O<sub>4</sub>-NPs against doxorubicin (DOX)-induced toxicity. In addition, Co<sub>3</sub>O<sub>4</sub>-NPs were effective against hepatotoxicity, nephrotoxicity, and endocrine disruption in male albino rats. Multi-technique investigation in this study offers a comprehensive understanding and indicates promising biological applications of ZnO-NPs and Co<sub>3</sub>O<sub>4</sub>-NPs.</p></div>\",\"PeriodicalId\":397,\"journal\":{\"name\":\"Nano-Structures & Nano-Objects\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":5.4500,\"publicationDate\":\"2024-05-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Nano-Structures & Nano-Objects\",\"FirstCategoryId\":\"1\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S2352507X24000854\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q1\",\"JCRName\":\"Physics and Astronomy\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Nano-Structures & Nano-Objects","FirstCategoryId":"1","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S2352507X24000854","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"Physics and Astronomy","Score":null,"Total":0}
Comparative versatility and diverse biological applications of eco-friendly zinc oxide and cobalt oxide nanoparticles using Punica granatum L. peel extract
A fundamental element of nanotechnology today is the advancement of sustainable, environmentally friendly and economically viable approaches to green synthesis of nanomaterials. In this study, fresh aqueous extract of pomegranate peels was used as reducing and stabilizing agents in a rapid and eco-friendly approach for the synthesis of zinc oxide nanoparticles (ZnO-NPs) and cobalt oxide nanoparticles (Co3O4-NPs). X-ray diffraction (XRD), Scanning Electron Microscopy (SEM), Transmission electron microscope (TEM), Energy Dispersive Analysis of X-rays (EDX), and Fourier-transform Infrared Spectroscopy (FT-IR) were used to analyze the biosynthesized ZnO-NPs and Co3O4-NPs. XRD analysis confirmed the crystalline structures of ZnO-NPs and Co3O4-NPs as approximately 33.4 and 11.9 nm, respectively. SEM images showed distinct morphologies, while EDX and elemental mapping confirmed compositional integrity. FT-IR validated the characteristic functional groups present in both nanoparticles. TEM analysis provide the average particle size of ZnO-NPs and Co3O4-NPs were observed at 41.25 and 17.19 nm, respectively. The zeta potential of green synthesized ZnO-NPs and Co3O4-NPs were found to have a distinct peak at −12.5 and −16.3 mV, respectively. Both NPs have shown potent antimicrobial activity against four common pathogens, with increased antimicrobial activity against increasing concentrations of NPs. In vivo studies show a protective role for both ZnO-NPs and Co3O4-NPs against doxorubicin (DOX)-induced toxicity. In addition, Co3O4-NPs were effective against hepatotoxicity, nephrotoxicity, and endocrine disruption in male albino rats. Multi-technique investigation in this study offers a comprehensive understanding and indicates promising biological applications of ZnO-NPs and Co3O4-NPs.
期刊介绍:
Nano-Structures & Nano-Objects is a new journal devoted to all aspects of the synthesis and the properties of this new flourishing domain. The journal is devoted to novel architectures at the nano-level with an emphasis on new synthesis and characterization methods. The journal is focused on the objects rather than on their applications. However, the research for new applications of original nano-structures & nano-objects in various fields such as nano-electronics, energy conversion, catalysis, drug delivery and nano-medicine is also welcome. The scope of Nano-Structures & Nano-Objects involves: -Metal and alloy nanoparticles with complex nanostructures such as shape control, core-shell and dumbells -Oxide nanoparticles and nanostructures, with complex oxide/metal, oxide/surface and oxide /organic interfaces -Inorganic semi-conducting nanoparticles (quantum dots) with an emphasis on new phases, structures, shapes and complexity -Nanostructures involving molecular inorganic species such as nanoparticles of coordination compounds, molecular magnets, spin transition nanoparticles etc. or organic nano-objects, in particular for molecular electronics -Nanostructured materials such as nano-MOFs and nano-zeolites -Hetero-junctions between molecules and nano-objects, between different nano-objects & nanostructures or between nano-objects & nanostructures and surfaces -Methods of characterization specific of the nano size or adapted for the nano size such as X-ray and neutron scattering, light scattering, NMR, Raman, Plasmonics, near field microscopies, various TEM and SEM techniques, magnetic studies, etc .