治疗前异常脑电图与癫痫复发之间关系的荟萃分析

IF 2 4区 医学 Q3 CLINICAL NEUROLOGY
Juan Yao , Chengrong Liao , Yao Wang , Zheng Xiao
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引用次数: 0

摘要

背景研究人员对停用抗癫痫药物(ASM)的患者癫痫复发的风险因素进行了研究。这些研究旨在确定停用抗癫痫药物的最佳时间。脑电图结果是研究的风险因素之一。然而,治疗前的异常脑电图结果是否是 ASM 停药后复发的风险因素,目前仍不清楚。方法我们从 PubMed 和 Embase 数据库中检索文献,并使用纽卡斯尔-渥太华量表评估纳入研究的方法学质量。结果从数据库中共检索到 710 篇文章。经过筛选,最终纳入了 11 篇文章,涉及 1686 名癫痫患者。与正常脑电图相比,异常脑电图的几率比(OR)为1.10(P=0.50),I2值为32%(P=0.15)。亚组分析显示,儿童至青少年亚组脑电图异常的比值比为 1.21(P=0.27),儿童至成人亚组脑电图异常的比值比为 0.64(P=0.14)。单独的亚组分析显示,局灶性癫痫亚组的脑电图异常OR值为1.30(P=0.37),全身性癫痫和局灶性癫痫亚组的脑电图异常OR值为1.07(P=0.67)。治疗前和治疗后脑电图改变与癫痫复发的关系尚存争议。由于我们文章的局限性,还需要进一步的研究。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
A meta-analysis of the relationship between abnormal pretreatment EEG and epilepsy recurrence

Background

Researchers have studied the risk factors for epilepsy recurrence among patients who withdraw from antiseizure medication (ASM). These studies aimed to determine the optimal time for ASM withdrawal. EEG findings are one of the risk factors that has been studied. However, it remains unclear whether abnormal pretreatment EEG findings are a risk factor for recurrence after ASM withdrawal. We performed this meta-analysis to clarify this issue.

Methods

We retrieved literature from the PubMed and Embase databases, and used the NewcastleOttawa Scale to evaluate the methodological quality of the included studies. RevMan 5.3 software was used to analyse the data.

Results

In total,710 articles were retrieved from the databases. Ultimately, after screening, 11 articles involving 1686 patients with epilepsy were included. Compared with that for a normal EEG, the odds ratio (OR) for an abnormal EEG was 1.10 (P=0.50), with an I2 value of 32% (P=0.15). Subgroup analysis revealed that the children-to-adolescents subgroup had an OR of 1.21 (P=0.27), and the children-to-adults subgroup had an OR of 0.64 (P=0.14) for an abnormal EEG. A separate subgroup analysis revealed that the focal epilepsy subgroup had an OR of 1.30 (P=0.37), and the generalized epilepsy and focal epilepsy subgroup had an OR of 1.07 (P=0.67) for an abnormal EEG.

Conclusions

The risk of epilepsy recurrence is not related to pretreatment EEG findings, regardless of age or epilepsy classification. The associations of pre- and posttreatment EEG alterations with epilepsy recurrence are controversial. Due to the limitations of our article, further research is needed.

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来源期刊
Epilepsy Research
Epilepsy Research 医学-临床神经学
CiteScore
0.10
自引率
4.50%
发文量
143
审稿时长
62 days
期刊介绍: Epilepsy Research provides for publication of high quality articles in both basic and clinical epilepsy research, with a special emphasis on translational research that ultimately relates to epilepsy as a human condition. The journal is intended to provide a forum for reporting the best and most rigorous epilepsy research from all disciplines ranging from biophysics and molecular biology to epidemiological and psychosocial research. As such the journal will publish original papers relevant to epilepsy from any scientific discipline and also studies of a multidisciplinary nature. Clinical and experimental research papers adopting fresh conceptual approaches to the study of epilepsy and its treatment are encouraged. The overriding criteria for publication are novelty, significant clinical or experimental relevance, and interest to a multidisciplinary audience in the broad arena of epilepsy. Review articles focused on any topic of epilepsy research will also be considered, but only if they present an exceptionally clear synthesis of current knowledge and future directions of a research area, based on a critical assessment of the available data or on hypotheses that are likely to stimulate more critical thinking and further advances in an area of epilepsy research.
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