{"title":"环糊精对低摩尔质量聚乙二醇结晶的抑制作用","authors":"Ian W. Hamley, Valeria Castelletto","doi":"10.1021/acspolymersau.4c00024","DOIUrl":null,"url":null,"abstract":"We examine the effect of alpha-cyclodextrin (αCD) on the crystallization of poly(ethylene glycol) (PEG) [poly(ethylene oxide), PEO] in low-molar-mass polymers, with <i>M</i><sub>w</sub> = 1000, 3000, or 6000 g mol<sup>–1</sup>. Differential scanning calorimetry (DSC) and simultaneous synchrotron small-/wide-angle X-ray scattering (SAXS/WAXS) show that crystallization of PEG is suppressed by αCD, provided that the cyclodextrin content is sufficient. The PEG crystal structure is replaced by a hexagonal mesophase of αCD-threaded polymer chains. The αCD threading reduces the conformational flexibility of PEG and, hence, suppresses crystallization. These findings point to the use of cyclodextrin additives as a powerful means to tune the crystallization of PEG (PEO), which, in turn, will impact bulk properties including biodegradability.","PeriodicalId":72049,"journal":{"name":"ACS polymers Au","volume":"11 1","pages":""},"PeriodicalIF":4.7000,"publicationDate":"2024-05-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Cyclodextrin-Induced Suppression of the Crystallization of Low-Molar-Mass Poly(ethylene glycol)\",\"authors\":\"Ian W. Hamley, Valeria Castelletto\",\"doi\":\"10.1021/acspolymersau.4c00024\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"We examine the effect of alpha-cyclodextrin (αCD) on the crystallization of poly(ethylene glycol) (PEG) [poly(ethylene oxide), PEO] in low-molar-mass polymers, with <i>M</i><sub>w</sub> = 1000, 3000, or 6000 g mol<sup>–1</sup>. Differential scanning calorimetry (DSC) and simultaneous synchrotron small-/wide-angle X-ray scattering (SAXS/WAXS) show that crystallization of PEG is suppressed by αCD, provided that the cyclodextrin content is sufficient. The PEG crystal structure is replaced by a hexagonal mesophase of αCD-threaded polymer chains. The αCD threading reduces the conformational flexibility of PEG and, hence, suppresses crystallization. These findings point to the use of cyclodextrin additives as a powerful means to tune the crystallization of PEG (PEO), which, in turn, will impact bulk properties including biodegradability.\",\"PeriodicalId\":72049,\"journal\":{\"name\":\"ACS polymers Au\",\"volume\":\"11 1\",\"pages\":\"\"},\"PeriodicalIF\":4.7000,\"publicationDate\":\"2024-05-02\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"ACS polymers Au\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.1021/acspolymersau.4c00024\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q1\",\"JCRName\":\"POLYMER SCIENCE\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"ACS polymers Au","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1021/acspolymersau.4c00024","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"POLYMER SCIENCE","Score":null,"Total":0}
引用次数: 0
摘要
我们研究了α-环糊精（αCD）对低摩尔质量聚合物（Mw = 1000、3000 或 6000 g mol-1）中聚乙二醇（PEG）[聚环氧乙烷（PEO）]结晶的影响。差示扫描量热法（DSC）和同步辐射小角/广角 X 射线散射法（SAXS/WAXS）表明，只要环糊精含量足够，PEG 的结晶就会受到 αCD 的抑制。PEG 晶体结构被由αCD-螺纹聚合物链组成的六角介相取代。αCD 穿线降低了 PEG 的构象灵活性，从而抑制了结晶。这些发现表明，使用环糊精添加剂是调整 PEG（PEO）结晶的有力手段，而 PEG（PEO）的结晶反过来又会影响包括生物降解性在内的整体特性。
Cyclodextrin-Induced Suppression of the Crystallization of Low-Molar-Mass Poly(ethylene glycol)
We examine the effect of alpha-cyclodextrin (αCD) on the crystallization of poly(ethylene glycol) (PEG) [poly(ethylene oxide), PEO] in low-molar-mass polymers, with Mw = 1000, 3000, or 6000 g mol–1. Differential scanning calorimetry (DSC) and simultaneous synchrotron small-/wide-angle X-ray scattering (SAXS/WAXS) show that crystallization of PEG is suppressed by αCD, provided that the cyclodextrin content is sufficient. The PEG crystal structure is replaced by a hexagonal mesophase of αCD-threaded polymer chains. The αCD threading reduces the conformational flexibility of PEG and, hence, suppresses crystallization. These findings point to the use of cyclodextrin additives as a powerful means to tune the crystallization of PEG (PEO), which, in turn, will impact bulk properties including biodegradability.
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