免疫系统在早发型精神分裂症中的作用:从外周血中识别免疫特征基因和细胞

IF 2.9 4区 医学 Q3 IMMUNOLOGY
Zi Chen, Yuxue Li, Yao Gao, Xiaoxuan Fan, Xinzhe Du, Xinrong Li, Zhifen Liu, Sha Liu, Xiaohua Cao
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引用次数: 0

摘要

早发型精神分裂症(EOS)是精神分裂症(SCZ)的一种类型,发病年龄为 0.7 岁。我们的研究结果表明,SCZ 患者的免疫系统功能发生了改变。此外,CCL8、PSMD1、AVPR1B 和 SEMG1 可调控 EOS 的外周免疫细胞。此外,免疫特征基因和细胞有望成为 SCZ 的诊断标记和治疗靶点。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
The role of the immune system in early-onset schizophrenia: identifying immune characteristic genes and cells from peripheral blood
Early-onset schizophrenia (EOS) is a type of schizophrenia (SCZ) with an age of onset of < 18 years. An abnormal inflammatory immune system may be involved in the occurrence and development of SCZ. We aimed to identify the immune characteristic genes and cells involved in EOS and to further explore the pathogenesis of EOS from the perspective of immunology. We obtained microarray data from a whole-genome mRNA expression in peripheral blood mononuclear cells (PBMCs); 19 patients with EOS (age range: 14.79 ± 1.90) and 18 healthy controls (HC) (age range: 15.67 ± 2.40) were involved. We screened for differentially expressed genes (DEGs) using the Limma software package and modular genes using weighted gene co-expression network analysis (WGCNA). In addition, to identify immune characteristic genes and cells, we performed enrichment analysis, immune infiltration analysis, and receiver operating characteristic (ROC) curve analysis; we also used a random forest (RF), a support vector machine (SVM), and the LASSO-Cox algorithm. We selected the following immune characteristic genes: CCL8, PSMD1, AVPR1B and SEMG1. We employed a RF, a SVM, and the LASSO-Cox algorithm. We identified the following immune characteristic cells: activated mast cells, CD4+ memory resting T cells, resting mast cells, neutrophils and CD4+ memory activated T cells. In addition, the AUC values of the immune characteristic genes and cells were all > 0.7. Our results indicate that immune system function is altered in SCZ. In addition, CCL8, PSMD1, AVPR1B and SEMG1 may regulate peripheral immune cells in EOS. Further, immune characteristic genes and cells are expected to be diagnostic markers and therapeutic targets of SCZ.
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来源期刊
BMC Immunology
BMC Immunology 医学-免疫学
CiteScore
5.50
自引率
0.00%
发文量
54
审稿时长
1 months
期刊介绍: BMC Immunology is an open access journal publishing original peer-reviewed research articles in molecular, cellular, tissue-level, organismal, functional, and developmental aspects of the immune system as well as clinical studies and animal models of human diseases.
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