哥伦比亚 2 型糖尿病患者每周一次服用塞马鲁肽可控制血糖并减轻体重:COLIBRI 研究结果

IF 3.8 3区 医学 Q2 Medicine
Dagoberto Serpa-Díaz, Carlos A. Llanos-Florez, Ronald Serrano Uribe, Dora I. Molina de Salazar, German C. Giraldo-Gonzalez, Miguel Urina-Triana, Andres F. Suarez-Rodriguez, Maria A. Alzate-Vinasco
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引用次数: 0

摘要

引言 2 型糖尿病是一种常见病。本研究评估了哥伦比亚 2 型糖尿病患者在使用每周一次的塞马鲁肽后血糖控制和体重的变化。主要终点是评估从基线到研究结束期间糖化血红蛋白(HbA1c)的变化。次要终点包括从基线到研究结束的体重变化。研究还探讨了达到预定 HbA1c 目标的参与者比例以及研究结束时的体重减轻反应。大多数患者为女性(65%),平均年龄为 57 岁,HbA1c 中位数为 7.6%,体重中位数为 86 公斤。经过约 26 周的治疗后,semaglutide 可使 HbA1c 显著降低-0.88,体重降低-4.04 千克。研究结束时,HbA1c < 7% 的患者比例从 32% 增加到 66%。这些结果与之前的临床试验结果一致。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

Glycemic Control and Body Weight Reduction with Once-Weekly Semaglutide in Colombian Adults with Type 2 Diabetes: Findings from the COLIBRI Study

Glycemic Control and Body Weight Reduction with Once-Weekly Semaglutide in Colombian Adults with Type 2 Diabetes: Findings from the COLIBRI Study

Introduction

Type 2 diabetes is a prevalent condition. The change in glucose control and body weight with the use of once-weekly semaglutide was evaluated in individuals with Type 2 diabetes in Colombia.

Methods

This was a real-world, multi-centre, single-arm study involving adults in Colombia with Type 2 diabetes treated with once-weekly subcutaneous semaglutide for approximately 26 weeks. The primary endpoint assessed the change in glycated hemoglobin (HbA1c) from baseline to end of study. Secondary endpoints included changes in body weight from baseline to end of study. The study also explored the proportion of participants achieving predefined HbA1c targets and weight-loss responses at the end of the study.

Results

Data from 225 patients across 11 centers were collected. Most patients were women (65%), and the mean age of the population was 57 years with a median HbA1c of 7.6% and a median body weight of 86 kg. After approximately 26 weeks, semaglutide was associated with a significant reduction in HbA1c of − 0.88 and a body weight reduction of − 4.04kg. The proportion of patients with HbA1c < 7% increased from 32 to 66% at end of study.

Conclusion

Patients treated with once-weekly semaglutide experienced a clinically significant reduction in HbA1c and body weight. These results are in line with previous clinical trials.

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来源期刊
Diabetes Therapy
Diabetes Therapy Medicine-Endocrinology, Diabetes and Metabolism
CiteScore
6.90
自引率
7.90%
发文量
130
审稿时长
6 weeks
期刊介绍: Diabetes Therapy is an international, peer reviewed, rapid-publication (peer review in 2 weeks, published 3–4 weeks from acceptance) journal dedicated to the publication of high-quality clinical (all phases), observational, real-world, and health outcomes research around the discovery, development, and use of therapeutics and interventions (including devices) across all areas of diabetes. Studies relating to diagnostics and diagnosis, pharmacoeconomics, public health, epidemiology, quality of life, and patient care, management, and education are also encouraged. The journal is of interest to a broad audience of healthcare professionals and publishes original research, reviews, communications and letters. The journal is read by a global audience and receives submissions from all over the world. Diabetes Therapy will consider all scientifically sound research be it positive, confirmatory or negative data. Submissions are welcomed whether they relate to an international and/or a country-specific audience, something that is crucially important when researchers are trying to target more specific patient populations. This inclusive approach allows the journal to assist in the dissemination of all scientifically and ethically sound research.
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