感觉神经元对宿主免疫力的调节

IF 13.1 1区医学 Q1 IMMUNOLOGY

Trends in Immunology Pub Date : 2024-05-01 DOI:10.1016/j.it.2024.03.005

Telma Saraiva-Santos, Tiago H. Zaninelli, Felipe A. Pinho-Ribeiro

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引用次数: 0

摘要

最近的研究发现了感觉神经元在影响哺乳动物宿主免疫力方面的新作用，挑战了神经系统和免疫系统作为独立实体的传统观念。在这篇综述中，我们将深入探讨神经免疫学的这一开创性范例，并讨论最近的科学证据，即感觉神经元对宿主应对各种病原体和疾病（包括微生物感染和癌症）的影响。这些有价值的见解加深了我们对神经系统和免疫系统之间相互作用的理解，同时也为开发候选创新疗法干预免疫介导疾病铺平了道路，凸显了这一跨学科研究领域的重要性。

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Modulation of host immunity by sensory neurons

Recent studies have uncovered a new role for sensory neurons in influencing mammalian host immunity, challenging conventional notions of the nervous and immune systems as separate entities. In this review we delve into this groundbreaking paradigm of neuroimmunology and discuss recent scientific evidence for the impact of sensory neurons on host responses against a wide range of pathogens and diseases, encompassing microbial infections and cancers. These valuable insights enhance our understanding of the interactions between the nervous and immune systems, and also pave the way for developing candidate innovative therapeutic interventions in immune-mediated diseases highlighting the importance of this interdisciplinary research field.

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来源期刊

Trends in Immunology 医学-免疫学

CiteScore

25.10

自引率

0.60%

发文量

130

审稿时长

6-12 weeks

期刊介绍： Trends in Immunology serves as a vital platform for tracking advancements across various areas of immunology, offering concise reviews and hypothesis-driven viewpoints in each issue. With additional sections providing comprehensive coverage, the journal offers a holistic view of immunology. This broad perspective makes it an invaluable resource for researchers, educators, and students, facilitating the connection between basic and clinical immunology. Recognized as one of the top monthly review journals in its field, Trends in Immunology is highly regarded by the scientific community.