发现辅酶Q10作为抑郁症患者辅助治疗的潜在价值。

IF 2.9 3区医学 Q2 PHARMACOLOGY & PHARMACY

Journal of Clinical Psychopharmacology Pub Date : 2024-04-29 DOI:10.1097/jcp.0000000000001845

Mahnam Majmasanaye, Maryam Mehrpooya, Hasan Amiri, Azadeh Eshraghi

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引用次数: 0

摘要

抑郁症或精神冷漠是最常见的精神疾病，抑郁症存在于世界各地、所有国家和文化中。多项研究结果表明，使用具有抗氧化特性的化合物对抑郁症患者有疗效。辅酶 Q10（CoQ10）是一种脂溶性抗氧化剂，通过直接中和自由基或还原生育酚，防止氧化应激对线粒体活性的抑制，从而发挥抗氧化作用。本研究旨在探讨口服辅酶Q10对抑郁症患者的辅助治疗效果。

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Discovering the Potential Value of Coenzyme Q10 as an Adjuvant Treatment in Patients With Depression.

Depressive disorder or mental cold is the most common mental disorder, and depression exists all over the world and in all countries and cultures. The results of several studies have shown that using compounds with antioxidant properties has been fruitful in patients with depression. Coenzyme Q10 (CoQ10) is a fat-soluble antioxidant and exerts its antioxidant effect by directly neutralizing free radicals or reducing tocopherol and preventing the inhibition of mitochondrial activity because of oxidative stress. This study aimed to investigate the effects of oral CoQ10 in patients with depression as an adjunctive treatment.

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来源期刊

Journal of Clinical Psychopharmacology 医学-精神病学

CiteScore

4.00

自引率

3.40%

发文量

231

审稿时长

4-8 weeks

期刊介绍： Journal of Clinical Psychopharmacology, a leading publication in psychopharmacology, offers a wide range of articles reporting on clinical trials and studies, side effects, drug interactions, overdose management, pharmacogenetics, pharmacokinetics, and psychiatric effects of non-psychiatric drugs. The journal keeps clinician-scientists and trainees up-to-date on the latest clinical developments in psychopharmacologic agents, presenting the extensive coverage needed to keep up with every development in this fast-growing field.