在治疗仪引导的紫外线-A 光光疗中使用可控角膜离子透入递送系统定向递送核黄素

IF 2 3区 物理与天体物理 Q3 BIOCHEMICAL RESEARCH METHODS
Marco Lombardo, Sebastiano Serrao, Giuseppe Massimo Bernava, Giuseppe Lombardo
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引用次数: 0

摘要

使用带有角膜离子透入系统附件的治疗仪紫外线-A 装置,以图案化方式输送 0.22% 核黄素溶液,对七只供体眼球进行了角膜交联。治疗仪引导的 UV-A 光照射评估了核黄素的分布情况,并以 10 mW/cm2 的功率和 5.0 mm 的光束尺寸对角膜进行了 9 分钟的处理。在基线和治疗后 2 小时拍摄角膜地形图。利用角膜地形图抬高数据进行分析,结果显示,控制核黄素的输送导致了一致的梯度,中心水平(248 ± 79 μg/cm3)比周边水平(180 ± 72 μg/cm3,距离中心 ± 2.5 mm)高出 40%。Theranostic 引导的 UV-A 光照射导致角膜地形图发生显著变化,最佳拟合球值下降(-0.7 ± 0.2 D; p < 0.001),角膜高程图持续下移(-11.7 ± 3.7 μm)。变异系数为 2.5%,表明手术在实现显著、可靠的角膜平整方面表现出色。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

Spatial targeted delivery of riboflavin with a controlled corneal iontophoresis delivery system in theranostic-guided UV-A light photo-therapy

Spatial targeted delivery of riboflavin with a controlled corneal iontophoresis delivery system in theranostic-guided UV-A light photo-therapy

Seven human donor eye globes underwent corneal cross-linking using theranostic UV-A device with accessory corneal iontophoresis system for patterned delivery of a 0.22% riboflavin solution. Theranostic-guided UV-A light illumination assessed riboflavin distribution and treated corneas at 10 mW/cm2 for 9 min with a 5.0-mm beam size. Corneal topography maps were taken at baseline and 2-h post-treatment. Analysis utilized corneal topography elevation data, with results showing controlled riboflavin delivery led to a consistent gradient, with 40% higher levels centrally (248 ± 79 μg/cm3) than peripherally (180 ± 72 μg/cm3 at ±2.5 mm from the center). Theranostic-guided UV-A light irradiation resulted in significant changes in corneal topography, with a decrease in best-fit sphere value (−0.7 ± 0.2 D; p < 0.001) and consistent downward shift in corneal elevation map (−11.7 ± 3.7 μm). The coefficient of variation was 2.5%, indicating high procedure performance in achieving significant and reliable corneal flattening.

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来源期刊
Journal of Biophotonics
Journal of Biophotonics 生物-生化研究方法
CiteScore
5.70
自引率
7.10%
发文量
248
审稿时长
1 months
期刊介绍: The first international journal dedicated to publishing reviews and original articles from this exciting field, the Journal of Biophotonics covers the broad range of research on interactions between light and biological material. The journal offers a platform where the physicist communicates with the biologist and where the clinical practitioner learns about the latest tools for the diagnosis of diseases. As such, the journal is highly interdisciplinary, publishing cutting edge research in the fields of life sciences, medicine, physics, chemistry, and engineering. The coverage extends from fundamental research to specific developments, while also including the latest applications.
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