A. Boots , A. Schrantee , A.M. Wiegersma , S. Aflalo , P.F.C. Groot , T.J. Roseboom , S.R. de Rooij
{"title":"孕早期遭受荷兰饥荒后，74 岁时执行 Stroop 任务时的大脑活动","authors":"A. Boots , A. Schrantee , A.M. Wiegersma , S. Aflalo , P.F.C. Groot , T.J. Roseboom , S.R. de Rooij","doi":"10.1016/j.bandc.2024.106162","DOIUrl":null,"url":null,"abstract":"<div><h3>Objective</h3><p>Poorer performance on the Stroop task has been reported after prenatal famine exposure at age 58, potentially indicating cognitive decline. We investigated whether brain activation during Stroop task performance at age 74 differed between individuals exposed to famine prenatally, individuals born before and individuals conceived after the famine.</p></div><div><h3>Method</h3><p>In the Dutch famine birth cohort, we performed a Stroop task fMRI study of individuals exposed (n = 22) or unexposed (born before (n = 18) or conceived after (n = 25)) to famine in early gestation. We studied group differences in task-related mean activation of the dorsolateral prefrontal cortex (DLPFC), anterior cingulate cortex (ACC) and posterior parietal cortex (PPC). Additionally, we explored potential disconnectivity of the DLPFC using psychophysiological interaction analysis.</p></div><div><h3>Results</h3><p>We observed similar activation patterns in the DLPFC, ACC and PPC in individuals born before and individuals exposed to famine, while individuals conceived after famine had generally higher activation patterns. However, activation patterns were not significantly different between groups. Task-related decreases in connectivity were observed between left DLPFC-left PPC and right DLPFC-right PPC, but were not significantly different between groups.</p></div><div><h3>Conclusions</h3><p>Although not statistically significant, the observed patterns of activation may reflect a combined effect of general brain aging and prenatal famine exposure.</p></div>","PeriodicalId":55331,"journal":{"name":"Brain and Cognition","volume":"177 ","pages":"Article 106162"},"PeriodicalIF":2.2000,"publicationDate":"2024-05-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S0278262624000393/pdfft?md5=c0d9ce8dc1325d163b134f56f6050616&pid=1-s2.0-S0278262624000393-main.pdf","citationCount":"0","resultStr":"{\"title\":\"Brain activity during Stroop task performance at age 74 after exposure to the Dutch famine during early gestation\",\"authors\":\"A. Boots , A. Schrantee , A.M. Wiegersma , S. Aflalo , P.F.C. Groot , T.J. Roseboom , S.R. de Rooij\",\"doi\":\"10.1016/j.bandc.2024.106162\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><h3>Objective</h3><p>Poorer performance on the Stroop task has been reported after prenatal famine exposure at age 58, potentially indicating cognitive decline. We investigated whether brain activation during Stroop task performance at age 74 differed between individuals exposed to famine prenatally, individuals born before and individuals conceived after the famine.</p></div><div><h3>Method</h3><p>In the Dutch famine birth cohort, we performed a Stroop task fMRI study of individuals exposed (n = 22) or unexposed (born before (n = 18) or conceived after (n = 25)) to famine in early gestation. We studied group differences in task-related mean activation of the dorsolateral prefrontal cortex (DLPFC), anterior cingulate cortex (ACC) and posterior parietal cortex (PPC). Additionally, we explored potential disconnectivity of the DLPFC using psychophysiological interaction analysis.</p></div><div><h3>Results</h3><p>We observed similar activation patterns in the DLPFC, ACC and PPC in individuals born before and individuals exposed to famine, while individuals conceived after famine had generally higher activation patterns. However, activation patterns were not significantly different between groups. Task-related decreases in connectivity were observed between left DLPFC-left PPC and right DLPFC-right PPC, but were not significantly different between groups.</p></div><div><h3>Conclusions</h3><p>Although not statistically significant, the observed patterns of activation may reflect a combined effect of general brain aging and prenatal famine exposure.</p></div>\",\"PeriodicalId\":55331,\"journal\":{\"name\":\"Brain and Cognition\",\"volume\":\"177 \",\"pages\":\"Article 106162\"},\"PeriodicalIF\":2.2000,\"publicationDate\":\"2024-05-03\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://www.sciencedirect.com/science/article/pii/S0278262624000393/pdfft?md5=c0d9ce8dc1325d163b134f56f6050616&pid=1-s2.0-S0278262624000393-main.pdf\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Brain and Cognition\",\"FirstCategoryId\":\"102\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S0278262624000393\",\"RegionNum\":3,\"RegionCategory\":\"心理学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q3\",\"JCRName\":\"NEUROSCIENCES\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Brain and Cognition","FirstCategoryId":"102","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S0278262624000393","RegionNum":3,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"NEUROSCIENCES","Score":null,"Total":0}
Brain activity during Stroop task performance at age 74 after exposure to the Dutch famine during early gestation
Objective
Poorer performance on the Stroop task has been reported after prenatal famine exposure at age 58, potentially indicating cognitive decline. We investigated whether brain activation during Stroop task performance at age 74 differed between individuals exposed to famine prenatally, individuals born before and individuals conceived after the famine.
Method
In the Dutch famine birth cohort, we performed a Stroop task fMRI study of individuals exposed (n = 22) or unexposed (born before (n = 18) or conceived after (n = 25)) to famine in early gestation. We studied group differences in task-related mean activation of the dorsolateral prefrontal cortex (DLPFC), anterior cingulate cortex (ACC) and posterior parietal cortex (PPC). Additionally, we explored potential disconnectivity of the DLPFC using psychophysiological interaction analysis.
Results
We observed similar activation patterns in the DLPFC, ACC and PPC in individuals born before and individuals exposed to famine, while individuals conceived after famine had generally higher activation patterns. However, activation patterns were not significantly different between groups. Task-related decreases in connectivity were observed between left DLPFC-left PPC and right DLPFC-right PPC, but were not significantly different between groups.
Conclusions
Although not statistically significant, the observed patterns of activation may reflect a combined effect of general brain aging and prenatal famine exposure.
期刊介绍：
Brain and Cognition is a forum for the integration of the neurosciences and cognitive sciences. B&C publishes peer-reviewed research articles, theoretical papers, case histories that address important theoretical issues, and historical articles into the interaction between cognitive function and brain processes. The focus is on rigorous studies of an empirical or theoretical nature and which make an original contribution to our knowledge about the involvement of the nervous system in cognition. Coverage includes, but is not limited to memory, learning, emotion, perception, movement, music or praxis in relationship to brain structure or function. Published articles will typically address issues relating some aspect of cognitive function to its neurological substrates with clear theoretical import, formulating new hypotheses or refuting previously established hypotheses. Clinical papers are welcome if they raise issues of theoretical importance or concern and shed light on the interaction between brain function and cognitive function. We welcome review articles that clearly contribute a new perspective or integration, beyond summarizing the literature in the field; authors of review articles should make explicit where the contribution lies. We also welcome proposals for special issues on aspects of the relation between cognition and the structure and function of the nervous system. Such proposals can be made directly to the Editor-in-Chief from individuals interested in being guest editors for such collections.
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