日本成年人的乳制品消费量、骨转换生物标志物和骨超声评估指数：磐城健康促进项目数据的横断面分析

IF 2.1 Q3 ENDOCRINOLOGY & METABOLISM

Bone Reports Pub Date : 2024-04-29 DOI:10.1016/j.bonr.2024.101770

Ayatake Nakano , Hiroshi M. Ueno , Daisuke Kawata , Yota Tatara , Yoshinori Tamada , Tatsuya Mikami , Koichi Murashita , Shigeyuki Nakaji , Ken Itoh

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引用次数: 0

摘要

目的乳制品是钙、磷、蛋白质和其他营养物质的营养来源，可改善骨骼健康。然而，日本人食用乳制品对骨生物标志物的影响仍不清楚。这项研究探讨了日本成年人食用乳制品与骨骼生物标志物之间的关系。方法这项横断面研究是日本青森县磐城健康促进项目的一部分。共有 1063 名成年人参与了分析。研究人员在当地居民的年度体检中测量了他们的骨转换标志物水平。使用定量超声波技术计算了小腿骨骨超声评估指数（OSI）。食物和营养素的膳食摄入量通过食物频率问卷进行估算。利用乳制品消费量和骨生物标志物建立线性回归模型。结果在多变量模型中，在对年龄和性别进行调整后，抗酒石酸磷酸酶 5b 和甲状旁腺激素的浓度与膳食中乳制品的摄入量成反比。在经调整的多变量模型中，欠羧化骨钙素、I型胶原蛋白N末端肽与骨碱性磷酸酶的比率以及OSI与乳制品摄入量直接相关。习惯性食用乳制品食品可能有助于补充营养以保持骨骼健康，包括骨转换和骨结构。临床试验登记号及获取网站日本临床试验登记（UMIN000040459），https://center6.umin.ac.jp/cgi-open-bin/ctr/ctr_view.cgi?recptno=R000046175。

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Dairy consumption, bone turnover biomarkers, and osteo sono assessment index in Japanese adults: A cross-sectional analysis of data from the Iwaki Health Promotion Project

Purpose

Dairy foods are nutritional sources of calcium, phosphorus, protein, and other nutrients that improve bone health. However, the effects of dairy consumption on bone biomarkers in the Japanese population remain unclear. This study explored the association between dairy consumption and bone biomarkers in Japanese adults.

Methods

This cross-sectional study was conducted as part of the Iwaki Health Promotion Project in Aomori, Japan. In total, 1063 adults were included in the analysis. Bone turnover marker levels were measured in local citizens during their annual medical checkups. The calcaneus osteo sono assessment index (OSI) was calculated using a quantitative ultrasound technique. The dietary intake of foods and nutrients was estimated using a food frequency questionnaire. Linear regression models were established using dairy consumption and bone biomarkers with adjustments. Statistic significance was considered by P < 0.05.

Results

In multivariate models, the tartrate-resistant acid phosphatase 5b and parathyroid hormone concentrations were inversely associated with dietary dairy consumption after adjusting for age and sex. The undercarboxylated osteocalcin, a procollagen type I N-terminal peptide to bone alkaline phosphatase ratio, and OSI were the directly associated with dairy consumption in multivariate models with adjustment.

Conclusions

Dairy consumption is partially associated with bone turnover biomarkers and OSI in adult Japanese participants. Habitual consumption of dairy foods may contribute to the nutritional supplementation for maintaining bone health, including turnover and structure.

Clinical trial registry number and website where it was obtained

The Japanese Clinical Trials Registry (UMIN000040459), https://center6.umin.ac.jp/cgi-open-bin/ctr/ctr_view.cgi?recptno=R000046175.

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来源期刊

Bone Reports Medicine-Orthopedics and Sports Medicine

CiteScore

4.30

自引率

4.00%

发文量

444

审稿时长

57 days

期刊介绍： Bone Reports is an interdisciplinary forum for the rapid publication of Original Research Articles and Case Reports across basic, translational and clinical aspects of bone and mineral metabolism. The journal publishes papers that are scientifically sound, with the peer review process focused principally on verifying sound methodologies, and correct data analysis and interpretation. We welcome studies either replicating or failing to replicate a previous study, and null findings. We fulfil a critical and current need to enhance research by publishing reproducibility studies and null findings.