José-Miguel Guzmán-García PhD , Manuel Romero-Saldaña PhD , Guillermo Molina-Recio PhD , Carlos Álvarez-Fernández PhD , María del Rocío Jiménez-Mérida PhD , Rafael Molina-Luque PhD
{"title":"工作人群中通常定义的代谢健康表型和肥胖与肺功能之间的关系:横断面研究","authors":"José-Miguel Guzmán-García PhD , Manuel Romero-Saldaña PhD , Guillermo Molina-Recio PhD , Carlos Álvarez-Fernández PhD , María del Rocío Jiménez-Mérida PhD , Rafael Molina-Luque PhD","doi":"10.1016/j.hrtlng.2024.04.017","DOIUrl":null,"url":null,"abstract":"<div><h3>Background</h3><p>Four phenotypes relate metabolism and obesity: metabolically healthy (MHO) and unhealthy (MUO) people with obesity and metabolically healthy (MHNO) and unhealthy (MUNO) people without obesity. No studies have addressed the association between these categories and lung function in the working population.</p></div><div><h3>Objectives</h3><p>The aim was to determine the relationship of phenotypes to lung ageing as measured by lung age and its relationship to lung dysfunction.</p></div><div><h3>Methods</h3><p>A descriptive cross-sectional study was conducted in a working population. The outcome variable was lung function assessed by lung age. The four phenotypes of obesity and metabolic health (MHNO, MHO, MUO and MUNO) were determined using NCEP-ATP III criteria. Lung dysfunctions were classified into restrictive, obstructive, and mixed patterns.</p></div><div><h3>Results</h3><p>The mean age of the participants was 43.7 years, ranging from 18 to 67 years. Of the 1860 workers, 51.3 % were women. The prevalences found were 71.4 %, 12 %, 10.6 % and 6 % for MHNO, MUO, MHO, and MUNO, respectively. MHO (β = 0.66; <em>p</em> = 0.591) was not associated with increased lung ageing compared with MHNO, but MUO (β = 7.1; <em>p</em> < 0.001) and MUNO (β = 6.6; <em>p</em> < 0.001) were. Concerning pulmonary dysfunctions, MUNO (OR = 1.93; <em>p</em> < 0.001) and MUO (OR = 2.91; <em>p</em> < 0.001) were found to be related to the presence of a restrictive pattern, and MUNO (OR = 2.40; <em>p</em> = 0.028) to the mixed pattern.</p></div><div><h3>Conclusion</h3><p>The results show that metabolic abnormalities, not obesity, are responsible for premature lung ageing and, therefore, lung function decline. In our study, having obesity without metabolic abnormality was not significantly associated with the presence of dysfunctional respiratory patterns.</p></div>","PeriodicalId":55064,"journal":{"name":"Heart & Lung","volume":null,"pages":null},"PeriodicalIF":2.4000,"publicationDate":"2024-05-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S0147956324000785/pdfft?md5=46c4dc3ecde5aba01edb64783ed46c2f&pid=1-s2.0-S0147956324000785-main.pdf","citationCount":"0","resultStr":"{\"title\":\"Relationship between commonly defined metabolic health phenotypes and obesity with lung function in a working population: A cross-sectional study\",\"authors\":\"José-Miguel Guzmán-García PhD , Manuel Romero-Saldaña PhD , Guillermo Molina-Recio PhD , Carlos Álvarez-Fernández PhD , María del Rocío Jiménez-Mérida PhD , Rafael Molina-Luque PhD\",\"doi\":\"10.1016/j.hrtlng.2024.04.017\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><h3>Background</h3><p>Four phenotypes relate metabolism and obesity: metabolically healthy (MHO) and unhealthy (MUO) people with obesity and metabolically healthy (MHNO) and unhealthy (MUNO) people without obesity. No studies have addressed the association between these categories and lung function in the working population.</p></div><div><h3>Objectives</h3><p>The aim was to determine the relationship of phenotypes to lung ageing as measured by lung age and its relationship to lung dysfunction.</p></div><div><h3>Methods</h3><p>A descriptive cross-sectional study was conducted in a working population. The outcome variable was lung function assessed by lung age. The four phenotypes of obesity and metabolic health (MHNO, MHO, MUO and MUNO) were determined using NCEP-ATP III criteria. Lung dysfunctions were classified into restrictive, obstructive, and mixed patterns.</p></div><div><h3>Results</h3><p>The mean age of the participants was 43.7 years, ranging from 18 to 67 years. Of the 1860 workers, 51.3 % were women. The prevalences found were 71.4 %, 12 %, 10.6 % and 6 % for MHNO, MUO, MHO, and MUNO, respectively. MHO (β = 0.66; <em>p</em> = 0.591) was not associated with increased lung ageing compared with MHNO, but MUO (β = 7.1; <em>p</em> < 0.001) and MUNO (β = 6.6; <em>p</em> < 0.001) were. Concerning pulmonary dysfunctions, MUNO (OR = 1.93; <em>p</em> < 0.001) and MUO (OR = 2.91; <em>p</em> < 0.001) were found to be related to the presence of a restrictive pattern, and MUNO (OR = 2.40; <em>p</em> = 0.028) to the mixed pattern.</p></div><div><h3>Conclusion</h3><p>The results show that metabolic abnormalities, not obesity, are responsible for premature lung ageing and, therefore, lung function decline. 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Relationship between commonly defined metabolic health phenotypes and obesity with lung function in a working population: A cross-sectional study
Background
Four phenotypes relate metabolism and obesity: metabolically healthy (MHO) and unhealthy (MUO) people with obesity and metabolically healthy (MHNO) and unhealthy (MUNO) people without obesity. No studies have addressed the association between these categories and lung function in the working population.
Objectives
The aim was to determine the relationship of phenotypes to lung ageing as measured by lung age and its relationship to lung dysfunction.
Methods
A descriptive cross-sectional study was conducted in a working population. The outcome variable was lung function assessed by lung age. The four phenotypes of obesity and metabolic health (MHNO, MHO, MUO and MUNO) were determined using NCEP-ATP III criteria. Lung dysfunctions were classified into restrictive, obstructive, and mixed patterns.
Results
The mean age of the participants was 43.7 years, ranging from 18 to 67 years. Of the 1860 workers, 51.3 % were women. The prevalences found were 71.4 %, 12 %, 10.6 % and 6 % for MHNO, MUO, MHO, and MUNO, respectively. MHO (β = 0.66; p = 0.591) was not associated with increased lung ageing compared with MHNO, but MUO (β = 7.1; p < 0.001) and MUNO (β = 6.6; p < 0.001) were. Concerning pulmonary dysfunctions, MUNO (OR = 1.93; p < 0.001) and MUO (OR = 2.91; p < 0.001) were found to be related to the presence of a restrictive pattern, and MUNO (OR = 2.40; p = 0.028) to the mixed pattern.
Conclusion
The results show that metabolic abnormalities, not obesity, are responsible for premature lung ageing and, therefore, lung function decline. In our study, having obesity without metabolic abnormality was not significantly associated with the presence of dysfunctional respiratory patterns.
期刊介绍:
Heart & Lung: The Journal of Cardiopulmonary and Acute Care, the official publication of The American Association of Heart Failure Nurses, presents original, peer-reviewed articles on techniques, advances, investigations, and observations related to the care of patients with acute and critical illness and patients with chronic cardiac or pulmonary disorders.
The Journal''s acute care articles focus on the care of hospitalized patients, including those in the critical and acute care settings. Because most patients who are hospitalized in acute and critical care settings have chronic conditions, we are also interested in the chronically critically ill, the care of patients with chronic cardiopulmonary disorders, their rehabilitation, and disease prevention. The Journal''s heart failure articles focus on all aspects of the care of patients with this condition. Manuscripts that are relevant to populations across the human lifespan are welcome.