干细胞的本杰明-巴顿效应逆转衰老免疫的时钟

IF 17.6 1区医学 Q1 IMMUNOLOGY

Science Immunology Pub Date : 2024-05-03 DOI:10.1126/sciimmunol.adq0013

Luciana Conde, Carolina Lucas

引用次数: 0

摘要

以抗体为基础的疗法能消耗髓系造血干细胞（my-HSCs），使免疫系统恢复活力，改善老龄小鼠的免疫反应。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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The Benjamin Button effect on stem cells: Reversing the clock on aging immunity

Antibody-based therapy depletes myeloid-biased hematopoietic stem cells (my-HSCs) to rejuvenate the immune system and improve immune responses in aged mice.

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来源期刊

Science Immunology Immunology and Microbiology-Immunology

CiteScore

32.90

自引率

2.00%

发文量

183

期刊介绍： Science Immunology is a peer-reviewed journal that publishes original research articles in the field of immunology. The journal encourages the submission of research findings from all areas of immunology, including studies on innate and adaptive immunity, immune cell development and differentiation, immunogenomics, systems immunology, structural immunology, antigen presentation, immunometabolism, and mucosal immunology. Additionally, the journal covers research on immune contributions to health and disease, such as host defense, inflammation, cancer immunology, autoimmunity, allergy, transplantation, and immunodeficiency. Science Immunology maintains the same high-quality standard as other journals in the Science family and aims to facilitate understanding of the immune system by showcasing innovative advances in immunology research from all organisms and model systems, including humans.