昆布茶对秀丽隐杆线虫的影响

IF 5.9 3区农林科学 Q1 VETERINARY SCIENCES

Lab Animal Pub Date : 2024-05-03 DOI:10.1038/s41684-024-01367-6

Alexandra Le Bras

引用次数: 0

摘要

昆布茶--一种经过发酵的茶--据称对健康有益，包括降低血压和预防代谢疾病。然而，昆布茶相关微生物（KTM）对宿主新陈代谢产生有益影响的机制仍然未知。一项新的研究利用线虫秀丽隐杆线虫作为动物模型系统来研究宿主对 KTM 的生理反应，结果表明 KTM 在秀丽隐杆线虫肠道内定植并限制宿主体内脂质的积累。转录组分析表明，与喂食对照微生物的动物相比，喂食 KTM 的动物体内参与脂肪吞噬的溶酶体脂肪酶上调，而甘油三酯合成的一种关键酶下调。这些发现与所报道的昆布茶对人类健康的益处相一致，并为了解驱动宿主对 KTMs 反应的机制提供了新的视角：DuMez-Kornegay, R.N. et al.20, e1011003 (2024)

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来源期刊

Lab Animal 农林科学-兽医学

CiteScore

0.60

自引率

2.90%

发文量

181

审稿时长

>36 weeks

期刊介绍： LabAnimal is a Nature Research journal dedicated to in vivo science and technology that improves our basic understanding and use of model organisms of human health and disease. In addition to basic research, methods and technologies, LabAnimal also covers important news, business and regulatory matters that impact the development and application of model organisms for preclinical research. LabAnimal's focus is on innovative in vivo methods, research and technology covering a wide range of model organisms. Our broad scope ensures that the work we publish reaches the widest possible audience. LabAnimal provides a rigorous and fair peer review of manuscripts, high standards for copyediting and production, and efficient publication.